Effect of high fructose corn sirup on pancreatic ductal adenocarcinoma induced by dimethyl benzantracene (DMBA) in rats

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dc.contributor.authorİnan, Sevda
dc.contributor.authorAkgül, Mustafa Barış
dc.contributor.authorBağdaş, Deniz
dc.contributor.buuauthorSinir-Özcan, Gülşah
dc.contributor.buuauthorSuna, Senem
dc.contributor.buuauthorTamer, Canan Ece
dc.contributor.buuauthorSönmez, Gürsel
dc.contributor.buuauthorEvrensel, Türkkan
dc.contributor.buuauthorKaya, Ekrem
dc.contributor.buuauthorSarandöl, Emre
dc.contributor.buuauthorDündar, Halit Ziya
dc.contributor.buuauthorTarım, Ömer Faruk
dc.contributor.buuauthorErcan, İlker
dc.contributor.buuauthorSığırlı, Deniz
dc.contributor.buuauthorİncedayı, Bige
dc.contributor.buuauthorÇopur, Ömer Utku
dc.contributor.departmentBursa Uludağ Üniversitesi/Ziraat Fakültesi/Gıda Mühendisliği Bölümü.tr_TR
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.tr_TR
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı.tr_TR
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Endokrinolojisi Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-3954-0058tr_TR
dc.contributor.orcid0000-0002-6947-2167tr_TR
dc.contributor.orcid0000-0003-0441-1707tr_TR
dc.contributor.orcid0000-0003-1840-1825tr_TR
dc.contributor.orcid0000-0002-9732-5340tr_TR
dc.contributor.orcid0000-0002-9562-4195tr_TR
dc.contributor.orcid0000-0002-2593-7196tr_TR
dc.contributor.orcid0000-0002-7346-7440tr_TR
dc.contributor.orcid0000-0002-5322-5508tr_TR
dc.contributor.orcid0000-0002-2382-290Xtr_TR
dc.contributor.orcid0000-0001-5871-8769tr_TR
dc.contributor.orcid0000-0001-6128-7453tr_TR
dc.contributor.orcid0000-0002-1951-7937tr_TR
dc.contributor.researcheridAAG-8277-2021tr_TR
dc.contributor.researcheridABE-1716-2020tr_TR
dc.contributor.researcheridAAQ-8178-2020tr_TR
dc.contributor.researcheridAAJ-1027-2021tr_TR
dc.contributor.researcheridAAG-7319-2021tr_TR
dc.contributor.researcheridAAG-8503-2021tr_TR
dc.contributor.researcheridAAG-8336-2021tr_TR
dc.contributor.researcheridAAA-7472-2021tr_TR
dc.contributor.researcheridABF-2367-2020tr_TR
dc.contributor.scopusid57194441710tr_TR
dc.contributor.scopusid55512747500tr_TR
dc.contributor.scopusid8228159500tr_TR
dc.contributor.scopusid55167435000tr_TR
dc.contributor.scopusid6603942124tr_TR
dc.contributor.scopusid7004568109tr_TR
dc.contributor.scopusid55943324800tr_TR
dc.contributor.scopusid55453773300tr_TR
dc.contributor.scopusid6701427186tr_TR
dc.date.accessioned2023-02-02T10:33:14Z
dc.date.available2023-02-02T10:33:14Z
dc.date.issued2020-05-12
dc.description.abstractIncreased risk of pancreatic cancer may be associated with consumption of sugar containing foods. The aim of this study was to evaluate the effect of peach nectar containing high fructose corn sirup (HFCS) consumption in a pancreatic carcinogenesis rat model induced by 7,12-Dimethyl benzanthracene (DMBA). Fifty-day-old male Sprague Dawley rats were fed with peach nectar containing HFCS + chow, peach nectar containing sucrose + chow and only chow. After 8 mo, feeding period, each group was divided into two subgroups, in which the rats were implanted with DMBA and no DMBA (sham). Histologic specimens were evaluated according to the routine tissue processing protocol. The animals withad libitumaccess to pn-HFCS, pn-sucrose and chow (only) showed significant differences in chow consumption and glucose level. Necropsy and histopathologic findings showed tumor formation in the entire group treated with DMBA. Excluding one rat in chow group, which was classified as poorly differentiated type, the others were classified as moderately differentiated pancreatic ductal adenocarcinoma (PDAC). This study demonstrated that daily intake of HFCS did not increase body weight and there was no effect of peach nectar consumption on the development of PDAC induced by DMBA in rats.en_US
dc.identifier.citationSinir-Özcan, G. vd. (2021). "Effect of high fructose corn sirup on pancreatic ductal adenocarcinoma induced by dimethyl benzantracene (DMBA) in rats". Nutrition and Cancer, 73(2), 339-349.en_US
dc.identifier.endpage349tr_TR
dc.identifier.issn0163-5581
dc.identifier.issn1532-7914
dc.identifier.issue2tr_TR
dc.identifier.pubmed32475178tr_TR
dc.identifier.scopus2-s2.0-85086577033tr_TR
dc.identifier.startpage339tr_TR
dc.identifier.urihttps://doi.org/10.1080/01635581.2020.1770811
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/01635581.2020.1770811
dc.identifier.urihttp://hdl.handle.net/11452/30791
dc.identifier.volume73tr_TR
dc.identifier.wos000542464600001tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherRoutledge Journalsen_US
dc.relation.bapUAP(Z) 2011/65tr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalNutrition and Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNormal dietary consumptionen_US
dc.subjectCancer-risken_US
dc.subjectInsulin-resistanceen_US
dc.subjectPooled analysisen_US
dc.subjectIntraepithelial neoplasiaen_US
dc.subjectGlycemic loaden_US
dc.subjectBody-weighten_US
dc.subjectGlucoseen_US
dc.subjectObesityen_US
dc.subjectSugaren_US
dc.subjectOncologyen_US
dc.subjectNutrition & dieteticsen_US
dc.subject.emtree7,12 dimethylbenz[a]anthraceneen_US
dc.subject.emtreeCorn syrupen_US
dc.subject.emtreeGlucoseen_US
dc.subject.emtreeSucroseen_US
dc.subject.emtreeFructoseen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAutopsyen_US
dc.subject.emtreeBody weighten_US
dc.subject.emtreeCancer morphologyen_US
dc.subject.emtreeCarcinogenesisen_US
dc.subject.emtreeChow dieten_US
dc.subject.emtreeClinical evaluationen_US
dc.subject.emtreeComparative studyen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeData analysis softwareen_US
dc.subject.emtreeFood intakeen_US
dc.subject.emtreeFructose intakeen_US
dc.subject.emtreeGlucose blood levelen_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNectaren_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePancreas adenocarcinomaen_US
dc.subject.emtreePeachen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSham procedureen_US
dc.subject.emtreeSprague dawley raten_US
dc.subject.emtreeTumor differentiationen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeMaizeen_US
dc.subject.emtreePancreas carcinomaen_US
dc.subject.emtreePancreas tumoren_US
dc.subject.mesh9,10-Dimethyl-1,2-benzanthraceneen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCarcinoma, pancreatic ductalen_US
dc.subject.meshFructoseen_US
dc.subject.meshHigh fructose corn syrupen_US
dc.subject.meshMaleen_US
dc.subject.meshPancreatic neoplasmsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshZea maysen_US
dc.subject.scopusPancreatic Neoplasms; Pancreas Adenocarcinoma; Chronic Pancreatitisen_US
dc.subject.wosOncologyen_US
dc.subject.wosNutrition & dieteticsen_US
dc.titleEffect of high fructose corn sirup on pancreatic ductal adenocarcinoma induced by dimethyl benzantracene (DMBA) in ratsen_US
dc.typeArticle
dc.wos.quartileQ3 (Nutrition & dietetics)en_US
dc.wos.quartileQ4en_US

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