Effect of high fructose corn sirup on pancreatic ductal adenocarcinoma induced by dimethyl benzantracene (DMBA) in rats
dc.contributor.author | İnan, Sevda | |
dc.contributor.author | Akgül, Mustafa Barış | |
dc.contributor.author | Bağdaş, Deniz | |
dc.contributor.buuauthor | Sinir-Özcan, Gülşah | |
dc.contributor.buuauthor | Suna, Senem | |
dc.contributor.buuauthor | Tamer, Canan Ece | |
dc.contributor.buuauthor | Sönmez, Gürsel | |
dc.contributor.buuauthor | Evrensel, Türkkan | |
dc.contributor.buuauthor | Kaya, Ekrem | |
dc.contributor.buuauthor | Sarandöl, Emre | |
dc.contributor.buuauthor | Dündar, Halit Ziya | |
dc.contributor.buuauthor | Tarım, Ömer Faruk | |
dc.contributor.buuauthor | Ercan, İlker | |
dc.contributor.buuauthor | Sığırlı, Deniz | |
dc.contributor.buuauthor | İncedayı, Bige | |
dc.contributor.buuauthor | Çopur, Ömer Utku | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Ziraat Fakültesi/Gıda Mühendisliği Bölümü. | tr_TR |
dc.contributor.department | Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı. | tr_TR |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı. | tr_TR |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Endokrinolojisi Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0003-3954-0058 | tr_TR |
dc.contributor.orcid | 0000-0002-6947-2167 | tr_TR |
dc.contributor.orcid | 0000-0003-0441-1707 | tr_TR |
dc.contributor.orcid | 0000-0003-1840-1825 | tr_TR |
dc.contributor.orcid | 0000-0002-9732-5340 | tr_TR |
dc.contributor.orcid | 0000-0002-9562-4195 | tr_TR |
dc.contributor.orcid | 0000-0002-2593-7196 | tr_TR |
dc.contributor.orcid | 0000-0002-7346-7440 | tr_TR |
dc.contributor.orcid | 0000-0002-5322-5508 | tr_TR |
dc.contributor.orcid | 0000-0002-2382-290X | tr_TR |
dc.contributor.orcid | 0000-0001-5871-8769 | tr_TR |
dc.contributor.orcid | 0000-0001-6128-7453 | tr_TR |
dc.contributor.orcid | 0000-0002-1951-7937 | tr_TR |
dc.contributor.researcherid | AAG-8277-2021 | tr_TR |
dc.contributor.researcherid | ABE-1716-2020 | tr_TR |
dc.contributor.researcherid | AAQ-8178-2020 | tr_TR |
dc.contributor.researcherid | AAJ-1027-2021 | tr_TR |
dc.contributor.researcherid | AAG-7319-2021 | tr_TR |
dc.contributor.researcherid | AAG-8503-2021 | tr_TR |
dc.contributor.researcherid | AAG-8336-2021 | tr_TR |
dc.contributor.researcherid | AAA-7472-2021 | tr_TR |
dc.contributor.researcherid | ABF-2367-2020 | tr_TR |
dc.contributor.scopusid | 57194441710 | tr_TR |
dc.contributor.scopusid | 55512747500 | tr_TR |
dc.contributor.scopusid | 8228159500 | tr_TR |
dc.contributor.scopusid | 55167435000 | tr_TR |
dc.contributor.scopusid | 6603942124 | tr_TR |
dc.contributor.scopusid | 7004568109 | tr_TR |
dc.contributor.scopusid | 55943324800 | tr_TR |
dc.contributor.scopusid | 55453773300 | tr_TR |
dc.contributor.scopusid | 6701427186 | tr_TR |
dc.date.accessioned | 2023-02-02T10:33:14Z | |
dc.date.available | 2023-02-02T10:33:14Z | |
dc.date.issued | 2020-05-12 | |
dc.description.abstract | Increased risk of pancreatic cancer may be associated with consumption of sugar containing foods. The aim of this study was to evaluate the effect of peach nectar containing high fructose corn sirup (HFCS) consumption in a pancreatic carcinogenesis rat model induced by 7,12-Dimethyl benzanthracene (DMBA). Fifty-day-old male Sprague Dawley rats were fed with peach nectar containing HFCS + chow, peach nectar containing sucrose + chow and only chow. After 8 mo, feeding period, each group was divided into two subgroups, in which the rats were implanted with DMBA and no DMBA (sham). Histologic specimens were evaluated according to the routine tissue processing protocol. The animals withad libitumaccess to pn-HFCS, pn-sucrose and chow (only) showed significant differences in chow consumption and glucose level. Necropsy and histopathologic findings showed tumor formation in the entire group treated with DMBA. Excluding one rat in chow group, which was classified as poorly differentiated type, the others were classified as moderately differentiated pancreatic ductal adenocarcinoma (PDAC). This study demonstrated that daily intake of HFCS did not increase body weight and there was no effect of peach nectar consumption on the development of PDAC induced by DMBA in rats. | en_US |
dc.identifier.citation | Sinir-Özcan, G. vd. (2021). "Effect of high fructose corn sirup on pancreatic ductal adenocarcinoma induced by dimethyl benzantracene (DMBA) in rats". Nutrition and Cancer, 73(2), 339-349. | en_US |
dc.identifier.endpage | 349 | tr_TR |
dc.identifier.issn | 0163-5581 | |
dc.identifier.issn | 1532-7914 | |
dc.identifier.issue | 2 | tr_TR |
dc.identifier.pubmed | 32475178 | tr_TR |
dc.identifier.scopus | 2-s2.0-85086577033 | tr_TR |
dc.identifier.startpage | 339 | tr_TR |
dc.identifier.uri | https://doi.org/10.1080/01635581.2020.1770811 | |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/01635581.2020.1770811 | |
dc.identifier.uri | http://hdl.handle.net/11452/30791 | |
dc.identifier.volume | 73 | tr_TR |
dc.identifier.wos | 000542464600001 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Routledge Journals | en_US |
dc.relation.bap | UAP(Z) 2011/65 | tr_TR |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.collaboration | Yurt dışı | tr_TR |
dc.relation.journal | Nutrition and Cancer | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Normal dietary consumption | en_US |
dc.subject | Cancer-risk | en_US |
dc.subject | Insulin-resistance | en_US |
dc.subject | Pooled analysis | en_US |
dc.subject | Intraepithelial neoplasia | en_US |
dc.subject | Glycemic load | en_US |
dc.subject | Body-weight | en_US |
dc.subject | Glucose | en_US |
dc.subject | Obesity | en_US |
dc.subject | Sugar | en_US |
dc.subject | Oncology | en_US |
dc.subject | Nutrition & dietetics | en_US |
dc.subject.emtree | 7,12 dimethylbenz[a]anthracene | en_US |
dc.subject.emtree | Corn syrup | en_US |
dc.subject.emtree | Glucose | en_US |
dc.subject.emtree | Sucrose | en_US |
dc.subject.emtree | Fructose | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Animal tissue | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Autopsy | en_US |
dc.subject.emtree | Body weight | en_US |
dc.subject.emtree | Cancer morphology | en_US |
dc.subject.emtree | Carcinogenesis | en_US |
dc.subject.emtree | Chow diet | en_US |
dc.subject.emtree | Clinical evaluation | en_US |
dc.subject.emtree | Comparative study | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Data analysis software | en_US |
dc.subject.emtree | Food intake | en_US |
dc.subject.emtree | Fructose intake | en_US |
dc.subject.emtree | Glucose blood level | en_US |
dc.subject.emtree | Histopathology | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Nectar | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Pancreas adenocarcinoma | en_US |
dc.subject.emtree | Peach | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Sham procedure | en_US |
dc.subject.emtree | Sprague dawley rat | en_US |
dc.subject.emtree | Tumor differentiation | en_US |
dc.subject.emtree | Animal | en_US |
dc.subject.emtree | Maize | en_US |
dc.subject.emtree | Pancreas carcinoma | en_US |
dc.subject.emtree | Pancreas tumor | en_US |
dc.subject.mesh | 9,10-Dimethyl-1,2-benzanthracene | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Carcinoma, pancreatic ductal | en_US |
dc.subject.mesh | Fructose | en_US |
dc.subject.mesh | High fructose corn syrup | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Pancreatic neoplasms | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, sprague-dawley | en_US |
dc.subject.mesh | Zea mays | en_US |
dc.subject.scopus | Pancreatic Neoplasms; Pancreas Adenocarcinoma; Chronic Pancreatitis | en_US |
dc.subject.wos | Oncology | en_US |
dc.subject.wos | Nutrition & dietetics | en_US |
dc.title | Effect of high fructose corn sirup on pancreatic ductal adenocarcinoma induced by dimethyl benzantracene (DMBA) in rats | en_US |
dc.type | Article | |
dc.wos.quartile | Q3 (Nutrition & dietetics) | en_US |
dc.wos.quartile | Q4 | en_US |
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