Publication:
Pharmacokinetics, biodistribution, and anti-angiogenesis efficacy of diamino propane tetraiodothyroacetic acid-conjugated biodegradable polymeric nanoparticle (Retracted Article)

dc.contributor.authorLi, Weikun
dc.contributor.authorBharali, Dhruba J.
dc.contributor.authorLin, Qishan
dc.contributor.authorGodugu, Kavitha
dc.contributor.authorFujioka, Kazutoshi
dc.contributor.authorKeating, Kelly A.
dc.contributor.authorMousa, Shaker A.
dc.contributor.buuauthorYalçın, Murat
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.departmentFizyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-5600-8162
dc.contributor.researcheridAAG-6956-2021
dc.contributor.scopusid57192959734
dc.date.accessioned2023-03-23T13:13:51Z
dc.date.available2023-03-23T13:13:51Z
dc.date.issued2019-06-21
dc.description.abstractThe anti-angiogenic agent, diamino propane tetraiodothyroacetic acid (DAT), is a thyro-integrin (integrin alpha v beta 3) antagonist anticancer agent that works via genetic and nongenetic actions. Tetraiodothyroacetic acid (tetrac) and DAT as thyroid hormone derivatives influence gene expression after they transport across cellular membranes. To restrict the action of DAT to the integrin alpha v beta 3 receptors on the cell surface, we used DAT-conjugated PLGA nanoparticles (NDAT) in an active targeting mode to bind to these receptors. Preparation and characterization of NDAT is described, and both in vitro and in vivo experiments were done to compare DAT to NDAT. Intracellular uptake and distribution of DAT and NDAT in U87 glioblastoma cells were evaluated using confocal microscopy and showed that DAT reached the nucleus, but NDAT was restricted from the nucleus. Pharmacokinetic studies using LC-MS/MS analysis in male C57BL/6 mice showed that administration of NDAT improved the area under the drug concentration curve AUC(()(0-)(48 h)) by 4-fold at a dose of 3 mg/kg when compared with DAT, and C-max of NDAT (4363 ng/mL) was 8-fold greater than that of DAT (548 ng/ mL). Biodistribution studies in the mice showed that the concentrations of NDAT were higher than DAT/Cremophor EL micelles in heart, lung, liver, spleen, and kidney. In another mouse model using female NCr nude homozygous mice with U87 xenografts, tumor growth was significantly decreased at doses of 1 and 3 mg/kg of NDAT. In the chick chorioallantoic membrane (CAM) assay used to measure angiogenesis, DAT (500 ng/CAM) resulted in 48% inhibition of angiogenesis levels. In comparison, NDAT at low dose (50 ng/CAM) showed 45% inhibition of angiogenesis levels. Our investigation of NDAT bridges the study of polymeric nanoparticles and anti-angiogenic agents and offers new insight for the rational design of anti-angiogenic agents.
dc.description.sponsorshipPharmaceutical Research Institute (PRI)
dc.description.sponsorshipNanoPharmaceuticals LLC (Rensselaer, NY, USA)
dc.identifier.citationLi, W. vd. (2019). 'Pharmacokinetics, biodistribution, and anti-angiogenesis efficacy of diamino propane tetraiodothyroacetic acid-conjugated biodegradable polymeric nanoparticle''. Scientific Reports, 9.
dc.identifier.issn2045-2322
dc.identifier.pubmed31227723
dc.identifier.scopus2-s2.0-85067797360
dc.identifier.urihttps://doi.org/10.1038/s41598-019-44979-6
dc.identifier.urihttps://www.nature.com/articles/s41598-019-44979-6
dc.identifier.urihttp://hdl.handle.net/11452/31721
dc.identifier.volume9
dc.identifier.wos000472477300005
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherNature
dc.relation.collaborationYurt dışı
dc.relation.collaborationSanayi
dc.relation.journalScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectScience & technology - other topics
dc.subjectDependent cellular uptake
dc.subjectTargeted delivery
dc.subjectThyroid-hormone
dc.subjectClinical translation
dc.subjectCancer-therapy
dc.subjectCremophor el
dc.subjectIn-vitro
dc.subjectDrung
dc.subjectPaclitaxel
dc.subjectTetrac
dc.subject.emtreeBiomaterial
dc.subject.emtreeNanoparticle
dc.subject.emtreePolymer
dc.subject.emtreePropane
dc.subject.emtreeTetraiodothyroacetic acid
dc.subject.emtreeThyroxine
dc.subject.emtreeAnimal
dc.subject.emtreeC57BL mouse
dc.subject.emtreeChemistry
dc.subject.emtreeChicken
dc.subject.emtreeChorioallantois
dc.subject.emtreeDrug effect
dc.subject.emtreeDrug screening
dc.subject.emtreeFemale
dc.subject.emtreeGlioblastoma
dc.subject.emtreeHuman
dc.subject.emtreeMale
dc.subject.emtreeMetabolism
dc.subject.emtreeNeovascularization (pathology)
dc.subject.emtreeNude mouse
dc.subject.emtreeProcedures
dc.subject.emtreeTissue distribution
dc.subject.emtreeTumor cell line
dc.subject.emtreeVascularization
dc.subject.meshAnimals
dc.subject.meshBiocompatible materials
dc.subject.meshCell Line, tumor
dc.subject.meshChickens
dc.subject.meshChorioallantoic membrane
dc.subject.meshFemale
dc.subject.meshGlioblastoma
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMice, inbred C57BL
dc.subject.meshMice, nude
dc.subject.meshNanoparticles
dc.subject.meshNeovascularization, pathologic
dc.subject.meshPolymers
dc.subject.meshPropane
dc.subject.meshThyroxine
dc.subject.meshTissue distribution
dc.subject.meshXenograft model antitumor assays
dc.subject.scopusIntegrin; Thyroid Hormones; Nano-Diamino-Tetrac
dc.subject.wosMultidisciplinary sciences
dc.titlePharmacokinetics, biodistribution, and anti-angiogenesis efficacy of diamino propane tetraiodothyroacetic acid-conjugated biodegradable polymeric nanoparticle (Retracted Article)
dc.typeArticle
dc.typeRetracted Publication
dc.wos.quartileQ1
dspace.entity.typePublication
local.contributor.departmentVeteriner Fakültesi/Fizyoloji Ana Bilim Dalı
local.indexed.atWOS
local.indexed.atScopus

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