Characterization of migraineurs having allodynia results of a large population-based study

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dc.contributor.authorBaykan, Betül
dc.contributor.authorEkizoğlu, Esme
dc.contributor.authorOrhan, Elif Kocasoy
dc.contributor.authorSaip, Sabahattin
dc.contributor.authorSiva, Aksel
dc.contributor.authorErtaş, Mustafa
dc.contributor.buuauthorKarlı, Necdet
dc.contributor.buuauthorZarifoğlu, Mehmet
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.tr_TR
dc.contributor.scopusid6506587942tr_TR
dc.contributor.scopusid6603411305tr_TR
dc.date.accessioned2022-10-27T10:06:28Z
dc.date.available2022-10-27T10:06:28Z
dc.date.issued2015-09-08
dc.description.abstractObjective: Allodynia reflects the clinical correlate of central sensitization, but it is usually neglected in clinical headache management. We aimed to report the prevalence and previously unnoticed associations of allodynia in migraineurs by a nationwide face-to-face questionnaire-based study by physicians. Methods: A total of 5323 households were examined for headache according to the diagnostic criteria of International Classification of Headache Disorders-II. Detailed headache features, premonitory signs, demographics, socio-economic status, and hormonal status of female individuals were analyzed with regard to the presence of allodynia in patients with definite migraine. Results: Allodynia was present in 61.1% of migraineurs in the general population of Turkey. The duration and severity of attacks (P < 0.0001), photophobia (P = 0.001), phonophobia, and also osmophobia (P < 0.0001), as well as premonitory signs (P = 0.018), showed significant associations with allodynia. Migraineurs with aura or family history of migraine more often reported allodynia in comparison with those without (P = 0.001 and 0.028, respectively). Allodynic migraineurs had a higher rate of physician consults and high levels on the Migraine Disability Assessment questionnaire, reflecting increased burden of headache. Furthermore, migraineurs with allodynia had high probability of attacks close to menses. Migraine improved during pregnancy, but it worsened after menopause or during oral contraceptive use in individuals experiencing allodynia when compared with those without allodynia. Discussion: The duration, severity, and disability of migraine attacks, photophobia, phonophobia, and osmophobia, as well as premonitory signs, showed significant associations with allodynia in the general population. Moreover, migraineurs with aura or family history of migraine more often reported allodynia, and allodynic migraneurs were more sensitive to hormonal changes. Allodynia, which seems to indicate higher tendency to central sensitization, should be implemented in daily headache practice to predict the prognosis and high levels of migraineous involvement.en_US
dc.description.sponsorshipİbrahim Ethem Ulagay-Menarini Group, Davutpaşa cad. Topkapı-İstanbul - 12en_US
dc.identifier.citationBaykan, B. vd. (2016). "Characterization of migraineurs having allodynia results of a large population-based study". Clinical Journal of Pain, 32(7), 631-635.en_US
dc.identifier.endpage635tr_TR
dc.identifier.issn0749-8047
dc.identifier.issn1536-5409
dc.identifier.issue7tr_TR
dc.identifier.pubmed26379076tr_TR
dc.identifier.scopus2-s2.0-84944342641tr_TR
dc.identifier.startpage631tr_TR
dc.identifier.urihttps://doi.org/10.1097/AJP.0000000000000301
dc.identifier.urihttps://journals.lww.com/clinicalpain/Fulltext/2016/07000/Characterization_of_Migraineurs_Having_Allodynia_.11.aspx
dc.identifier.urihttp://hdl.handle.net/11452/29236
dc.identifier.volume32tr_TR
dc.identifier.wos000378712600011tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalClinical Journal of Painen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnesthesiologyen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectMigraineen_US
dc.subjectHeadacheen_US
dc.subjectAllodyniaen_US
dc.subjectCutaneous allodyniaen_US
dc.subjectSpreading depressionen_US
dc.subjectAssociationen_US
dc.subjectHeadacheen_US
dc.subjectFeaturesen_US
dc.subjectSexen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAllodyniaen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeChronic daily headacheen_US
dc.subject.emtreeConsultationen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisease associationen_US
dc.subject.emtreeDisease durationen_US
dc.subject.emtreeDisease exacerbationen_US
dc.subject.emtreeDrug induced headacheen_US
dc.subject.emtreeFamily historyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHeadacheen_US
dc.subject.emtreeHigh risk patienten_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeInterviewen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMenopauseen_US
dc.subject.emtreeMenstrual migraineen_US
dc.subject.emtreeMIDAS (migraine)en_US
dc.subject.emtreeMigraineen_US
dc.subject.emtreeMigraine auraen_US
dc.subject.emtreeMigraine with auraen_US
dc.subject.emtreeNauseaen_US
dc.subject.emtreeOral contraceptive useen_US
dc.subject.emtreeOsmophobiaen_US
dc.subject.emtreePain severityen_US
dc.subject.emtreePhobiaen_US
dc.subject.emtreePhonophobiaen_US
dc.subject.emtreePhotophobiaen_US
dc.subject.emtreePhysicianen_US
dc.subject.emtreePregnancyen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProdromal symptomen_US
dc.subject.emtreeTransformed migraineen_US
dc.subject.emtreeTurkey (republic)en_US
dc.subject.emtreeVomitingen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeDisabilityen_US
dc.subject.emtreeHyperalgesiaen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeMigraine disordersen_US
dc.subject.emtreePrevalenceen_US
dc.subject.emtreeQuestionnaireen_US
dc.subject.emtreeSeverity of illness indexen_US
dc.subject.emtreeTurkeyen_US
dc.subject.emtreeYoung adulten_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshDisability evaluationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperalgesiaen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMigraine disordersen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshSeverity of illness indexen_US
dc.subject.meshSurveys and questionnairesen_US
dc.subject.meshTurkeyen_US
dc.subject.meshYoung adulten_US
dc.subject.scopusSumatriptan; Migraine Disorders; Hyperacusisen_US
dc.subject.wosAnesthesiologyen_US
dc.subject.wosClinical neurologyen_US
dc.titleCharacterization of migraineurs having allodynia results of a large population-based studyen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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