Oxidizability of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in preeclampsia

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dc.contributor.buuauthorSarandöl, Emre
dc.contributor.buuauthorŞafak, Özlem
dc.contributor.buuauthorMelahat, Dirican
dc.contributor.buuauthorUncu, Gürkan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-2593-7196tr_TR
dc.contributor.researcheridABE-1716-2020tr_TR
dc.contributor.researcheridAAG-6985-2021tr_TR
dc.contributor.scopusid55943324800tr_TR
dc.contributor.scopusid6508363078tr_TR
dc.contributor.scopusid6601919847tr_TR
dc.contributor.scopusid6603716169tr_TR
dc.date.accessioned2021-10-07T12:35:03Z
dc.date.available2021-10-07T12:35:03Z
dc.date.issued2004-11
dc.description.abstractLipoprotein oxidation has been implicated in the pathogenesis of preeclampsia and paraoxonase, an antioxidant enzyme shown to protect lipoproteins from being oxidized. The aim of the present study was to evaluate oxidizability of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in preeclampsia. Twenty-one women with mild preeclampsia, 21 women with severe preeclampsia, and 20 women with normal uncomplicated pregnancy were included in this study. Serum malondialdehyde (MDA) level, an indicator of lipid peroxidation, was measured by high-performance liquid chromatography (HPLC). The oxidizability of apolipoprotein B-containing lipoproteins was evaluated by copper-induced in vitro peroxidation of the isolated fraction of apolipoprotein B-containing lipoproteins coupled with the thiobarbituric acid-reactive substances assay and expressed as the difference between copper-treated MDA and basal MDA (ΔMDA). The serum paraoxonase and arylesterase activities were determined spectrophotometrically. Serum MDA and ΔMDA levels of apolipoprotein B-containing lipoproteins were significantly higher in both mild and severe preeclampsia groups than in the normal pregnant group. Serum paraoxonase and arylesterase activities were not significantly different among the study groups. Enhancement in oxidizability of apolipoprotein B-containing lipoproteins accompanying with dyslipidemia and increased serum MDA levels suggests that those lipoproteins play a role in the pathogenesis of preeclampsia. Further studies are needed to investigate serum paraoxonase activity in women with normal pregnancies and preeclampsia.en_US
dc.identifier.citationSarandöl, E. vd. (2004). “Oxidizability of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in preeclampsia”. Clinical Biochemistry, 37(11), 990-996.en_US
dc.identifier.endpage996tr_TR
dc.identifier.issn0009-9120
dc.identifier.issue11tr_TR
dc.identifier.pubmed15498527tr_TR
dc.identifier.scopus2-s2.0-6344220183tr_TR
dc.identifier.startpage990tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.clinbiochem.2004.06.013
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0009912004001791
dc.identifier.urihttp://hdl.handle.net/11452/22286
dc.identifier.volume37tr_TR
dc.identifier.wos000225389900008tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Scienceen_US
dc.relation.journalClinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArylesteraseen_US
dc.subjectLipoprotein oxidationen_US
dc.subjectMalondialdehydeen_US
dc.subjectParaoxonaseen_US
dc.subjectPreeclampsiaen_US
dc.subjectLow-density-lipoproteinen_US
dc.subjectPregnancy-induced hypertensionen_US
dc.subjectEndothelial dysfunctionen_US
dc.subjectOxidative modificationen_US
dc.subjectParaoxonase arylesteraseen_US
dc.subjectLipid-peroxidationen_US
dc.subjectHDL-cholesterolen_US
dc.subjectVitamin-Een_US
dc.subjectPlasmaen_US
dc.subjectWomenen_US
dc.subjectMedical laboratory technologyen_US
dc.subject.emtreeApolipoprotein Ben_US
dc.subject.emtreeAryldialkylphosphataseen_US
dc.subject.emtreeArylesteraseen_US
dc.subject.emtreeCopperen_US
dc.subject.emtreeLipiden_US
dc.subject.emtreeLipoproteinen_US
dc.subject.emtreeMalonaldehydeen_US
dc.subject.emtreeThiobarbituric acid reactive substanceen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAssayen_US
dc.subject.emtreeBlood levelen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisease severityen_US
dc.subject.emtreeEnzyme activityen_US
dc.subject.emtreeEvaluationen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHigh performance liquid chromatographyen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeIn vitro studyen_US
dc.subject.emtreeIsolation procedureen_US
dc.subject.emtreeLipid peroxidationen_US
dc.subject.emtreeMeasurementen_US
dc.subject.emtreeOxidationen_US
dc.subject.emtreePeroxidationen_US
dc.subject.emtreePreeclampsiaen_US
dc.subject.emtreePregnancyen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.emtreeSerumen_US
dc.subject.emtreeSpectrophotometryen_US
dc.subject.meshApolipoproteins Ben_US
dc.subject.meshAryldialkylphosphataseen_US
dc.subject.meshCarboxylic ester hydrolasesen_US
dc.subject.meshCopperen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLipid peroxidationen_US
dc.subject.meshLipoproteinsen_US
dc.subject.meshMalondialdehydeen_US
dc.subject.meshOxidation-reductionen_US
dc.subject.meshPre-eclampsiaen_US
dc.subject.meshPregnancyen_US
dc.subject.scopusPregnancy Toxemia; Maternal Hypertension; Eclampsiaen_US
dc.subject.wosMedical laboratory technologyen_US
dc.titleOxidizability of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in preeclampsiaen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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