Publication:
Caecum location in laboratory rats and mice: An anatomical and radiological study

dc.contributor.authorUysal, Murat
dc.contributor.authorGül, Serdar Savaş
dc.contributor.authorKaraman, Serhat
dc.contributor.authorTaş, Ufuk
dc.contributor.authorSapmaz, Hilal Irmak
dc.contributor.authorAytekin, Kurşad
dc.contributor.authorTümer, Mehmet Kemal
dc.contributor.buuauthorUysal, Funda
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFizyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0003-0717-4428
dc.contributor.scopusid57194426466
dc.date.accessioned2023-01-30T12:03:37Z
dc.date.available2023-01-30T12:03:37Z
dc.date.issued2017-06
dc.description.abstractIntraperitoneal (i.p.) injection is the most frequently used method for implementing parenteral therapies in rats and mice. Whether the caecum is located in the right caudal quadrant or left caudal quadrant in the abdominal cavity is not clear. For that reason, we have developed a method for identifying the location of the caecum in rats and mice and thus revealed the most reliable location for i.p. injection in these animals. Two hundred Wistar albino rats and 100 BALB/c mice were used. The location of the caecum was determined by revealing the intra-abdominal organs immediately following euthanasia, photographing the organs, and archiving the images. Both digital photographic images and computed tomographic (CT) sections were analysed in terms of caecum morphology and location. In both rats and mice, the caecum was most commonly located on the animal's left side. It was less frequently located on the right side or in the centre. The caecum was typically comma-shaped, but it was round or S-shaped in some animals. The direction of rotation of the caecum from the basis to the apex was mostly counterclockwise. Additionally, the apex showed a tendency to be evenly centred. This study demonstrated that the caecum was mostly located on the animal's left side; and for that reason, the most suitable location for i.p. injection in these animals was understood to be the right caudal quadrant. Furthermore, when we compared the CT images and autopsy findings, the caecum did not change location in the abdominal cavity postmortem.
dc.identifier.citationUysal, M. vd. (2017). ''Caecum location in laboratory rats and mice: An anatomical and radiological study''. Laboratory Animals, 51(3), 245-255.
dc.identifier.endpage255
dc.identifier.issn0023-6772
dc.identifier.issue3
dc.identifier.pubmed27381195
dc.identifier.scopus2-s2.0-85020117161
dc.identifier.startpage245
dc.identifier.urihttps://doi.org/10.1177/0023677216658916
dc.identifier.uri1758-1117
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/0023677216658916
dc.identifier.urihttp://hdl.handle.net/11452/30714
dc.identifier.volume51
dc.identifier.wos000401251400001
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherSage Puplications
dc.relation.collaborationYurt içi
dc.relation.collaborationSanayi
dc.relation.journalLaboratory Animals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectVeterinary sciences
dc.subjectZoology
dc.subjectCaecum
dc.subjectRat
dc.subjectMice
dc.subjectLocalization
dc.subjectMorphology
dc.subjectIntraperitoneal injection
dc.subjectCellulose
dc.subjectErrors
dc.subject.emtreeAbdominal cavity
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAutopsy
dc.subject.emtreeBagg albino mouse
dc.subject.emtreeCecum
dc.subject.emtreeControlled study
dc.subject.emtreeEuthanasia
dc.subject.emtreeIntraperitoneal drug administration
dc.subject.emtreeMorphology
dc.subject.emtreeMouse
dc.subject.emtreeNonhuman
dc.subject.emtreeOrgan
dc.subject.emtreeRat
dc.subject.emtreeRotation
dc.subject.emtreeWistar rat
dc.subject.emtreeAnatomy and histology
dc.subject.emtreeAnimal
dc.subject.emtreeCecum
dc.subject.emtreeProcedures
dc.subject.emtreeRat
dc.subject.emtreeWeterinary
dc.subject.emtreeWistar rat
dc.subject.meshAnimals
dc.subject.meshCecum
dc.subject.meshInjections
dc.subject.meshIntraperitoneal
dc.subject.meshMice
dc.subject.meshRats
dc.subject.meshRats
dc.subject.meshWistar
dc.subject.scopusAnimals; Retro; Punctures
dc.subject.wosVeterinary sciences
dc.subject.wosZoology
dc.titleCaecum location in laboratory rats and mice: An anatomical and radiological study
dc.typeArticle
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Fizyoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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