The clinical value of incidental F-18-fluorodeoxyglucose-avid foci detected on positron emission tomography/computed tomography

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dc.contributor.buuauthorÖzkol, Volkan
dc.contributor.buuauthorAlper, Eray
dc.contributor.buuauthorAydın, Nesrin
dc.contributor.buuauthorÖzkol, Hayriye Funda
dc.contributor.buuauthorTopal, Naile Bolca
dc.contributor.buuauthorAkpınar, Ali Tayyar
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nükleer Tıp Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAI-2327-2021tr_TR
dc.contributor.researcheridAAJ-8660-2021tr_TR
dc.contributor.scopusid35330464900tr_TR
dc.contributor.scopusid7006827670tr_TR
dc.contributor.scopusid57204375496tr_TR
dc.contributor.scopusid35330500100tr_TR
dc.contributor.scopusid13806674200tr_TR
dc.contributor.scopusid35329166000tr_TR
dc.date.accessioned2021-12-08T07:27:16Z
dc.date.available2021-12-08T07:27:16Z
dc.date.issued2010-02
dc.description.abstractObjective This study was performed to show the malignant potential and clinical value of incidental focal F-18-fluorodeoxyglucose (F-18-FDG) uptake on positron emission tomography/computed tomography (PET/CT) with the confirmation of histopathologic findings or with a series of consequent correlative imaging methods. Methods A total of 2370 F-18-FDG-PET/CT studies performed over a 16-month period in patients with various malignant diseases were retrospectively reviewed Unexpected PET foci that were in an unusual site for metastatic spread of known malignancy and not considered to be physiologic uptake were evaluated by histopathologic findings or follow-up with correlative imaging methods for a period of 1 year or longer. There were 121 such incidental PET lesions in 116 patients. Results Seventy-four incidental PET lesions in 70 PET/CT patients were investigated further. Forty-seven lesions in 46 patients were lost to follow-up. Fifty-nine lesions were confirmed histopathologically. Fifteen lesions were evaluated with radiologic methods or instrumental examination. Thirty-six incidental PET foci were unexpected malignant or premalignant lesions (1.5% of 2370 patients and 49% of 74 PET foci). Nineteen of these 36 malignant or premalignant lesions were synchronous carcinomas, 14 lesions were unusual or unexpected malignant spread of known malignancy and three lesions were premalignant colonic adenomas. Thirty-three of 74 incidental PET lesions were of benign origin (1.4% of 2370 patients and 44% of 74 PET foci). Five PET foci were false-positive findings (7% of 74 lesions). Conclusion The detection of incidental F-18-FDG-PET foci on PET/CT may reflect unexpected malignant lesions related to unusual malignant spread of primary malignancy or synchronous tumor. Follow-up of these PET foci may result in significant change in therapy management and early diagnosis of various abnormalities that require a medical approach or surgical intervention.en_US
dc.identifier.citationÖzkol, V. vd. (2010). "The clinical value of incidental F-18-fluorodeoxyglucose-avid foci detected on positron emission tomography/computed tomography". Nuclear Medicine Communications, 31(2), 128-136.en_US
dc.identifier.endpage136tr_TR
dc.identifier.issn0143-3636
dc.identifier.issn1473-5628
dc.identifier.issue2tr_TR
dc.identifier.pubmed19858768tr_TR
dc.identifier.scopus2-s2.0-75149145111tr_TR
dc.identifier.startpage128tr_TR
dc.identifier.urihttps://doi.org/10.1097/MNM.0b013e328332b30e
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/19858768/
dc.identifier.urihttp://hdl.handle.net/11452/23074
dc.identifier.volume31tr_TR
dc.identifier.wos000273466500007tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.journalNuclear Medicine Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCorrelative methodsen_US
dc.subjectF-18-fluorodeoxyglucoseen_US
dc.subjectIncidentalen_US
dc.subjectOncologyen_US
dc.subjectPositron emission tomography/computed tomographyen_US
dc.subjectFDG-PETen_US
dc.subjectFluorodeoxyglucose uptakeen_US
dc.subjectF-18-FDG uptakeen_US
dc.subjectPrevalenceen_US
dc.subjectInfectionen_US
dc.subjectPatternsen_US
dc.subjectTumorsen_US
dc.subjectCTen_US
dc.subjectRadiology, nuclear medicine & medical imagingen_US
dc.subject.emtreeFluorodeoxyglucose f 18en_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCcancer diagnosisen_US
dc.subject.emtreeColon adenomaen_US
dc.subject.emtreeColorectal carcinomaen_US
dc.subject.emtreeComputer assisted emission tomographyen_US
dc.subject.emtreeEarly diagnosisen_US
dc.subject.emtreeEndometrium carcinomaen_US
dc.subject.emtreeEsophageal adenocarcinomaen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFollow upen_US
dc.subject.emtreeHead and neck carcinomaen_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeKidney carcinomaen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMetastasisen_US
dc.subject.emtreePheochromocytomaen_US
dc.subject.emtreePhysiologyen_US
dc.subject.emtreePrecanceren_US
dc.subject.emtreePrimary tumoren_US
dc.subject.emtreeProstate carcinomaen_US
dc.subject.emtreeRetrospective studyen_US
dc.subject.emtreeSoft tissue sarcomaen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshBiological transporten_US
dc.subject.meshFalse positive reactionsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorodeoxyglucose F18en_US
dc.subject.meshHumansen_US
dc.subject.meshIncidental findingsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshNeoplasmsen_US
dc.subject.meshPositron-emission tomographyen_US
dc.subject.meshRetrospective studiesen_US
dc.subject.meshX-ray computeden_US
dc.subject.meshYoung adulten_US
dc.subject.scopusFluorodeoxyglucose F 18; Positron Emission Tomography Computed Tomography; Positron-emission Tomographyen_US
dc.subject.wosRadiology, nuclear medicine & medical imagingen_US
dc.titleThe clinical value of incidental F-18-fluorodeoxyglucose-avid foci detected on positron emission tomography/computed tomographyen_US
dc.typeArticle

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