Publication:
The effects of choline on body temperature in conscious rats

dc.contributor.buuauthorÜnal, Can B.
dc.contributor.buuauthorDemiral, Yücel
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFarmakoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-4281-0218
dc.contributor.researcheridD-5340-2015
dc.contributor.researcheridAAP-3351-2020
dc.date.accessioned2021-07-06T08:47:25Z
dc.date.available2021-07-06T08:47:25Z
dc.date.issued1998-12-18
dc.description.abstractCholine (75-300 mu g) produced dose-dependent hypothermia when injected intracerebroventricularly (i.c.v.). Pre-treatment with the muscarinic receptor antagonist, atropine (10 mu g, i.c.v.), blocked the hypothermic effect of choline (150 mu g), but the response was only partially attenuated by pre-treatment with the nicotinic receptor antagonist, mecamylamine (20 mu g, i.c.v.). Pirenzepine (25 mu g), a muscarinic M-1 receptor antagonist, or hexahydro-siladifenidol (HHSD) (100 mu g), a muscarinic M-3 receptor antagonist, also blocked choline-induced hypothermia when injected centrally. Unlike the other muscarinic receptor antagonists, M-2-selective 11-[[2-[(diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one (AF-DX116) (10 mu g), did not affect choline-induced hypothermia. We also found that choline-induced hypothermia was very sensitive to the ambient temperature. Similar to its effect at room temperature, choline produced dose-dependent hypothermia at 4 degrees C, but this effect was abolished at 32 degrees C. These data suggest that choline produces hypothermia and this effect is mediated by muscarinic receptors.
dc.identifier.citationÜnal, C. B. vd. (1998). "The effects of choline on body temperature in conscious rats". European Journal of Pharmacology, 363(2-3), 121-126.
dc.identifier.endpage126
dc.identifier.issn0014-2999
dc.identifier.issue2-3
dc.identifier.pubmed9881577
dc.identifier.scopus2-s2.0-0032545399
dc.identifier.startpage121
dc.identifier.urihttps://doi.org/10.1016/S0014-2999(98)00794-8
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0014299998007948
dc.identifier.urihttp://hdl.handle.net/11452/21115
dc.identifier.volume363
dc.identifier.wos000077627200005
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier Science BV
dc.relation.journalEuropean Journal of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPharmacology & pharmacy
dc.subjectCholine
dc.subjectThermoregulation
dc.subjectHypothermia
dc.subjectRat
dc.subjectMuscarinic receptor subtypes
dc.subjectAcetylcholine-release
dc.subjectInjected choline
dc.subjectCorpus striatum
dc.subjectBrain
dc.subjectPilocarpine
dc.subjectNeurons
dc.subjectHemicholinium-3
dc.subjectPotentiation
dc.subjectStimulation
dc.subject.wosPharmacology & pharmacy
dc.titleThe effects of choline on body temperature in conscious rats
dc.typeArticle
dc.wos.quartileQ1
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Farmakoloji Ana Bilim Dalı
local.indexed.atWOS
local.indexed.atScopus

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