Publication: The effects of choline on body temperature in conscious rats
dc.contributor.buuauthor | Ünal, Can B. | |
dc.contributor.buuauthor | Demiral, Yücel | |
dc.contributor.buuauthor | Ulus, İsmail Hakkı | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Farmakoloji Ana Bilim Dalı | |
dc.contributor.orcid | 0000-0002-4281-0218 | |
dc.contributor.researcherid | D-5340-2015 | |
dc.contributor.researcherid | AAP-3351-2020 | |
dc.date.accessioned | 2021-07-06T08:47:25Z | |
dc.date.available | 2021-07-06T08:47:25Z | |
dc.date.issued | 1998-12-18 | |
dc.description.abstract | Choline (75-300 mu g) produced dose-dependent hypothermia when injected intracerebroventricularly (i.c.v.). Pre-treatment with the muscarinic receptor antagonist, atropine (10 mu g, i.c.v.), blocked the hypothermic effect of choline (150 mu g), but the response was only partially attenuated by pre-treatment with the nicotinic receptor antagonist, mecamylamine (20 mu g, i.c.v.). Pirenzepine (25 mu g), a muscarinic M-1 receptor antagonist, or hexahydro-siladifenidol (HHSD) (100 mu g), a muscarinic M-3 receptor antagonist, also blocked choline-induced hypothermia when injected centrally. Unlike the other muscarinic receptor antagonists, M-2-selective 11-[[2-[(diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one (AF-DX116) (10 mu g), did not affect choline-induced hypothermia. We also found that choline-induced hypothermia was very sensitive to the ambient temperature. Similar to its effect at room temperature, choline produced dose-dependent hypothermia at 4 degrees C, but this effect was abolished at 32 degrees C. These data suggest that choline produces hypothermia and this effect is mediated by muscarinic receptors. | |
dc.identifier.citation | Ünal, C. B. vd. (1998). "The effects of choline on body temperature in conscious rats". European Journal of Pharmacology, 363(2-3), 121-126. | |
dc.identifier.endpage | 126 | |
dc.identifier.issn | 0014-2999 | |
dc.identifier.issue | 2-3 | |
dc.identifier.pubmed | 9881577 | |
dc.identifier.scopus | 2-s2.0-0032545399 | |
dc.identifier.startpage | 121 | |
dc.identifier.uri | https://doi.org/10.1016/S0014-2999(98)00794-8 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0014299998007948 | |
dc.identifier.uri | http://hdl.handle.net/11452/21115 | |
dc.identifier.volume | 363 | |
dc.identifier.wos | 000077627200005 | |
dc.indexed.scopus | Scopus | |
dc.indexed.wos | SCIE | |
dc.language.iso | en | |
dc.publisher | Elsevier Science BV | |
dc.relation.journal | European Journal of Pharmacology | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Pharmacology & pharmacy | |
dc.subject | Choline | |
dc.subject | Thermoregulation | |
dc.subject | Hypothermia | |
dc.subject | Rat | |
dc.subject | Muscarinic receptor subtypes | |
dc.subject | Acetylcholine-release | |
dc.subject | Injected choline | |
dc.subject | Corpus striatum | |
dc.subject | Brain | |
dc.subject | Pilocarpine | |
dc.subject | Neurons | |
dc.subject | Hemicholinium-3 | |
dc.subject | Potentiation | |
dc.subject | Stimulation | |
dc.subject.wos | Pharmacology & pharmacy | |
dc.title | The effects of choline on body temperature in conscious rats | |
dc.type | Article | |
dc.wos.quartile | Q1 | |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi/Farmakoloji Ana Bilim Dalı | |
local.indexed.at | WOS | |
local.indexed.at | Scopus |
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