Cardiovascular effects of CDP-choline and its metabolites: Involvement of peripheral autonomic nervous system

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dc.contributor.buuauthorCansev, Mehmet
dc.contributor.buuauthorYılmaz, Mustafa Serdar
dc.contributor.buuauthorİlçöl, Yeşim Özarda
dc.contributor.buuauthorHamurtekin, Emre
dc.contributor.buuauthorUlus, İsmil Hakkı
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-2918-5064tr_TR
dc.contributor.orcid0000-0001-9496-1475tr_TR
dc.contributor.researcheridAAH-1571-2021tr_TR
dc.contributor.researcheridD-5340-2015tr_TR
dc.contributor.researcheridM-9071-2019tr_TR
dc.contributor.researcheridAAL-8873-2021tr_TR
dc.contributor.scopusid8872816100tr_TR
dc.contributor.scopusid8895544100tr_TR
dc.contributor.scopusid35741320500tr_TR
dc.contributor.scopusid8717648500tr_TR
dc.contributor.scopusid7004271086tr_TR
dc.date.accessioned2022-09-12T08:45:12Z
dc.date.available2022-09-12T08:45:12Z
dc.date.issued2007-12-22
dc.description.abstractIntraperitoneal administration of CDP-choline (200-900 mu mol/kg) increased blood pressure and decreased heart rate of rats in a dose- and time-dependent manner. These responses were accompanied by elevated serum concentrations of CDP-choline and its metabolites phosphocholine, choline, cytidine monophosphate and cytidine. Blood pressure increased by intraperitoneal phosphocholine (200-900 mu mol/ kg), while it decreased by choline (200-600 mu mol/kg) administration; phosphocholine or choline administration (up to 600 mu mol/kg) decreased heart rate. Intraperitoneal cytidine monophosphate (200-600 mu mol/kg) or cytidine (200-600 mu mol/kg) increased blood pressure without affecting heart rate. Pressor responses to CDP-choline, phosphocholine, cytidine monophosphate or cytidine were not altered by pretreatment with atropine methyl nitrate or hexamethonium while hypotensive effect of choline was reversed to pressor effect by these pretreatments. Pretreatment with atropine plus hexamethonium attenuated or blocked pressor response to CDP-choline or phosphocholine, respectively. Heart rate responses to CDP-choline, phospbocholine and choline were blocked by atropine and reversed by hexamethonium. Cardiovascular responses to CDP-choline, phosphocholine and choline, but not cytidine monophosphate or cytidine, were associated with elevated plasma catecholamines concentrations. Blockade of alpha-adrenoceptors by prazosin or yohimbine attenuated pressor response to CDP-choline while these antagonists blocked pressor responses to phosphocholine or choline. Neither bilateral adrenalectomy nor chemical sympathectomy altered cardiovascular responses to CDPcholine, choline, cytidine monophosphate or cytidine. Sympathectomy attenuated pressor response to phosphocholine. Results show that intraperitoneal administration of CDP-choline and its metabolites alter cardiovascular parameters and suggest that peripheral cholinergic and adrenergic receptors are involved in these responses.en_US
dc.identifier.citationCansev, M. vd. (2007). "Cardiovascular effects of CDP-choline and its metabolites: Involvement of peripheral autonomic nervous system". European Journal of Pharmacology, 577(1-3), 129-142.en_US
dc.identifier.endpage142tr_TR
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.issue1-3tr_TR
dc.identifier.pubmed17884041tr_TR
dc.identifier.scopus2-s2.0-35449003300tr_TR
dc.identifier.startpage129tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.ejphar.2007.08.029
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0014299907009417
dc.identifier.urihttp://hdl.handle.net/11452/28641
dc.identifier.volume577tr_TR
dc.identifier.wos000251155000018tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevier Scienceen_US
dc.relation.journalEuropean Journal of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiovascularen_US
dc.subjectReverses hypotensionen_US
dc.subjectMuscarinic receptorsen_US
dc.subjectBlood-pressureen_US
dc.subjectAcetylcholineen_US
dc.subjectReleaseen_US
dc.subjectRaten_US
dc.subjectstrokeen_US
dc.subjectCiticolineen_US
dc.subjectMiceen_US
dc.subjectDogen_US
dc.subjectCDP-cholineen_US
dc.subjectCholineen_US
dc.subjectCytidineen_US
dc.subjectPhosphocholineen_US
dc.subject.emtreeYohimbineen_US
dc.subject.emtreeAtropineen_US
dc.subject.emtreeCatecholamineen_US
dc.subject.emtreeCholineen_US
dc.subject.emtreeCiticolineen_US
dc.subject.emtreeCytidineen_US
dc.subject.emtreeCytidine phosphateen_US
dc.subject.emtreeDexamethasoneen_US
dc.subject.emtreeHexamethoniumen_US
dc.subject.emtreePhosphorylcholineen_US
dc.subject.emtreePrazosinen_US
dc.subject.emtreePropranololen_US
dc.subject.emtreeVasopressinen_US
dc.subject.emtreeDrug antagonismen_US
dc.subject.emtreeAdrenalectomyen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAutonomic nervous systemen_US
dc.subject.emtreeBlood pressureen_US
dc.subject.emtreeCardiovascular effecten_US
dc.subject.emtreeCatecholamine blood levelen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeRug antagonismen_US
dc.subject.emtreeDrug blood levelen_US
dc.subject.emtreeHeart rateen_US
dc.subject.emtreeHypotensionen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeVasopressin blood levelen_US
dc.subject.emtreePlasma renin activityen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSympathectomyen_US
dc.subject.meshCatecholaminesen_US
dc.subject.meshAdrenal glandsen_US
dc.subject.meshAdrenalectomyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAorta, thoracicen_US
dc.subject.meshAutonomic nervous systemen_US
dc.subject.meshBlood pressureen_US
dc.subject.meshHeart rateen_US
dc.subject.meshCholineen_US
dc.subject.meshCytidineen_US
dc.subject.meshCytidine diphosphate cholineen_US
dc.subject.meshCytidine monophosphateen_US
dc.subject.meshHeart atriaen_US
dc.subject.meshPhosphorylcholineen_US
dc.subject.meshMaleen_US
dc.subject.meshNootropic agentsen_US
dc.subject.meshParasympathetic nervous systemen_US
dc.subject.meshPeripheral nervesen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, wistaren_US
dc.subject.meshReninen_US
dc.subject.meshSympathectomy, chemicalen_US
dc.subject.meshVasopressinsen_US
dc.subject.scopusCiticoline; Neuroprotective Agents; Glycerylphosphorylcholineen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleCardiovascular effects of CDP-choline and its metabolites: Involvement of peripheral autonomic nervous systemen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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