Overexpression of the long noncoding RNA homeoboxA transcript at the distal tip predicts poor prognosis in a KRAS-independent manner in periampullary region tumors

dc.contributor.buuauthorBalçın, Özkan
dc.contributor.buuauthorAk, Seçil Aksoy
dc.contributor.buuauthorTunca, Berrin
dc.contributor.buuauthorKaya, Ekrem
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorTezcan, Gülçin
dc.contributor.buuauthorUğraş, Nesrin
dc.contributor.buuauthorÇeçener, Gülşah
dc.contributor.buuauthorIşık, Özgen
dc.contributor.buuauthorDündar, Halit Ziya
dc.contributor.buuauthorYerci, Ömer
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalları.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-3760-9755tr_TR
dc.contributor.orcid0000-0002-1619-6680tr_TR
dc.contributor.orcid0000-0002-9562-4195tr_TR
dc.contributor.orcid0000-0001-7904-883Xtr_TR
dc.contributor.orcid0000-0002-5956-8755tr_TR
dc.contributor.orcid0000-0002-3820-424Xtr_TR
dc.contributor.orcid0000-0002-9541-5035tr_TR
dc.contributor.orcid0000-0002-7346-7440tr_TR
dc.contributor.researcheridADM-8457-2022tr_TR
dc.contributor.researcheridABI-6078-2020tr_TR
dc.contributor.researcheridAAG-7319-2021tr_TR
dc.contributor.researcheridAAH-1420-2021tr_TR
dc.contributor.researcheridAAH-3843-2020tr_TR
dc.contributor.researcheridAAH-2716-2021tr_TR
dc.contributor.researcheridAAP-9988-2020tr_TR
dc.contributor.researcheridP-5779-2019tr_TR
dc.contributor.researcheridABH-2238-2021tr_TR
dc.contributor.researcheridAAW-9602-2020tr_TR
dc.contributor.scopusid57189756976tr_TR
dc.contributor.scopusid57200365076tr_TR
dc.contributor.scopusid6602965754tr_TR
dc.contributor.scopusid7004568109tr_TR
dc.contributor.scopusid55665145000tr_TR
dc.contributor.scopusid25650627600tr_TR
dc.contributor.scopusid55386535600tr_TR
dc.contributor.scopusid6508156530tr_TR
dc.contributor.scopusid36600543700tr_TR
dc.contributor.scopusid55453773300tr_TR
dc.contributor.scopusid6603810549tr_TR
dc.date.accessioned2023-10-31T12:51:06Z
dc.date.available2023-10-31T12:51:06Z
dc.date.issued2018
dc.description.abstractObjectives: Periampullary region tumors (PRTs) are the fifth highest cause of cancer-related deaths worldwide. Although recent studies have highlighted the prognostic value of the long noncoding RNA HomeoboxA transcript at the distal tip (HOTTIP) in patients with pancreatic ductal adenocarcinoma, the relationship between HOTTIP and clinical outcome of all PRTs remains obscure. The aim of this study was to clarify the prognostic significance of HOTTIP in patients with all PRTs related to KRAS mutational status. Methods: HomeoboxA transcript at the distal tip expression was detected in 100 PRT samples using quantitative real-time polymerase chain reaction. The associations between HOTTIP levels, clinicopathological factors, and patient prognosis were also analyzed. Results: The expression of HOTTIP was found to be significantly upregulated by 32-fold (P = 0.031) in tumor tissues compared with normal tissues. The over expression of HOTTIP was related with presence of invasion and metastasis (P = 0.0467, P = 0.0256). In addition, increased HOTTIP expression was associated with poor prognosis independent of KRAS mutation (P < 0.001; n = 72). Moreover, multivariate analysis showed that high HOTTIP expression was an unfavorable prognostic factor for overall survival. Conclusions: Our findings indicate that high levels of HOTTIP expression have the potential to be an independent, unfavorable prognostic factor for patients with PRT.en_US
dc.identifier.citationBalçın, Ö. vd. (2018). ''Overexpression of the long noncoding RNA homeoboxA transcript at the distal tip predicts poor prognosis in a KRAS-independent manner in periampullary region tumors''. Pancreas, 47(2), 213-220.en_US
dc.identifier.endpage220tr_TR
dc.identifier.issn0885-3177
dc.identifier.issn1536-4828
dc.identifier.issue2tr_TR
dc.identifier.pubmed29329159tr_TR
dc.identifier.scopus2-s2.0-85040992161tr_TR
dc.identifier.startpage213tr_TR
dc.identifier.urihttps://doi.org/10.1097/MPA.0000000000000984
dc.identifier.urihttps://journals.lww.com/pancreasjournal/fulltext/2018/02000/overexpression_of_the_long_noncoding_rna_homeoboxa.10.aspx
dc.identifier.urihttp://hdl.handle.net/11452/34704
dc.identifier.volume47tr_TR
dc.identifier.wos000423205000013tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.bapBUAP(T)-2012/1tr_TR
dc.relation.journalPancreasen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGastroenterology & hepatologyen_US
dc.subjectLncRNAen_US
dc.subjectHOTTIPen_US
dc.subjectKRASen_US
dc.subjectPeriampullary region tumorsen_US
dc.subjectPrognosisen_US
dc.subjectPancreatic ductal adenocarcinomaen_US
dc.subjectCanceren_US
dc.subjectHotairen_US
dc.subjectHottipen_US
dc.subjectProgressionen_US
dc.subjectChromatinen_US
dc.subjectMetastasisen_US
dc.subjectExpressionen_US
dc.subjectBiomarkersen_US
dc.subjectEvolutionen_US
dc.subject.emtreeK ras proteinen_US
dc.subject.emtreeLong noncoding rna homeoboxa transcript at the distal tipen_US
dc.subject.emtreeLong untranslated RNAen_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeKRAS protein, humanen_US
dc.subject.emtreeLong noncoding RNA HOTTIP, humanen_US
dc.subject.emtreeLong untranslated RNAen_US
dc.subject.emtreeProtein p21en_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAssociationen_US
dc.subject.emtreeBile duct tumoren_US
dc.subject.emtreeBiliary tract canceren_US
dc.subject.emtreeCancer prognosisen_US
dc.subject.emtreeCancer survivalen_US
dc.subject.emtreeClinical featureen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDistant metastasisen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGene mutationen_US
dc.subject.emtreeGene overexpressionen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman tissueen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeOverall survivalen_US
dc.subject.emtreePancreas tumoren_US
dc.subject.emtreePancreaticoduodenectomyen_US
dc.subject.emtreePeriampullary region tumoren_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeQuantitative analysisen_US
dc.subject.emtreeReal time polymerase chain reactionen_US
dc.subject.emtreeTumor growthen_US
dc.subject.emtreeTumor localizationen_US
dc.subject.emtreeUpregulationen_US
dc.subject.emtreeVater papilla tumoren_US
dc.subject.emtreeGene expression regulationen_US
dc.subject.emtreeGeneticsen_US
dc.subject.emtreeKaplan meier methoden_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeMutationen_US
dc.subject.emtreePancreas carcinomaen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreePrognosisen_US
dc.subject.emtreeVery elderlyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshCarcinoma, pancreatic ductalen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene expression regulation, neoplasticen_US
dc.subject.meshHumansen_US
dc.subject.meshKaplan-meier estimateen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMutationen_US
dc.subject.meshPancreatic neoplasmsen_US
dc.subject.meshPrognosisen_US
dc.subject.meshProto-oncogene proteins p21(ras)en_US
dc.subject.meshRNA, long noncodingen_US
dc.subject.scopusMicrorna; Growth Arrest Specific Transcript 5; Small Nucleolar RNAen_US
dc.subject.wosGastroenterology & hepatologyen_US
dc.titleOverexpression of the long noncoding RNA homeoboxA transcript at the distal tip predicts poor prognosis in a KRAS-independent manner in periampullary region tumorsen_US
dc.typeArticle
dc.wos.quartileQ3en_US

Files

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: