Overexpression of the long noncoding RNA homeoboxA transcript at the distal tip predicts poor prognosis in a KRAS-independent manner in periampullary region tumors
dc.contributor.buuauthor | Balçın, Özkan | |
dc.contributor.buuauthor | Ak, Seçil Aksoy | |
dc.contributor.buuauthor | Tunca, Berrin | |
dc.contributor.buuauthor | Kaya, Ekrem | |
dc.contributor.buuauthor | Egeli, Ünal | |
dc.contributor.buuauthor | Tezcan, Gülçin | |
dc.contributor.buuauthor | Uğraş, Nesrin | |
dc.contributor.buuauthor | Çeçener, Gülşah | |
dc.contributor.buuauthor | Işık, Özgen | |
dc.contributor.buuauthor | Dündar, Halit Ziya | |
dc.contributor.buuauthor | Yerci, Ömer | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalları. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-3760-9755 | tr_TR |
dc.contributor.orcid | 0000-0002-1619-6680 | tr_TR |
dc.contributor.orcid | 0000-0002-9562-4195 | tr_TR |
dc.contributor.orcid | 0000-0001-7904-883X | tr_TR |
dc.contributor.orcid | 0000-0002-5956-8755 | tr_TR |
dc.contributor.orcid | 0000-0002-3820-424X | tr_TR |
dc.contributor.orcid | 0000-0002-9541-5035 | tr_TR |
dc.contributor.orcid | 0000-0002-7346-7440 | tr_TR |
dc.contributor.researcherid | ADM-8457-2022 | tr_TR |
dc.contributor.researcherid | ABI-6078-2020 | tr_TR |
dc.contributor.researcherid | AAG-7319-2021 | tr_TR |
dc.contributor.researcherid | AAH-1420-2021 | tr_TR |
dc.contributor.researcherid | AAH-3843-2020 | tr_TR |
dc.contributor.researcherid | AAH-2716-2021 | tr_TR |
dc.contributor.researcherid | AAP-9988-2020 | tr_TR |
dc.contributor.researcherid | P-5779-2019 | tr_TR |
dc.contributor.researcherid | ABH-2238-2021 | tr_TR |
dc.contributor.researcherid | AAW-9602-2020 | tr_TR |
dc.contributor.scopusid | 57189756976 | tr_TR |
dc.contributor.scopusid | 57200365076 | tr_TR |
dc.contributor.scopusid | 6602965754 | tr_TR |
dc.contributor.scopusid | 7004568109 | tr_TR |
dc.contributor.scopusid | 55665145000 | tr_TR |
dc.contributor.scopusid | 25650627600 | tr_TR |
dc.contributor.scopusid | 55386535600 | tr_TR |
dc.contributor.scopusid | 6508156530 | tr_TR |
dc.contributor.scopusid | 36600543700 | tr_TR |
dc.contributor.scopusid | 55453773300 | tr_TR |
dc.contributor.scopusid | 6603810549 | tr_TR |
dc.date.accessioned | 2023-10-31T12:51:06Z | |
dc.date.available | 2023-10-31T12:51:06Z | |
dc.date.issued | 2018 | |
dc.description.abstract | Objectives: Periampullary region tumors (PRTs) are the fifth highest cause of cancer-related deaths worldwide. Although recent studies have highlighted the prognostic value of the long noncoding RNA HomeoboxA transcript at the distal tip (HOTTIP) in patients with pancreatic ductal adenocarcinoma, the relationship between HOTTIP and clinical outcome of all PRTs remains obscure. The aim of this study was to clarify the prognostic significance of HOTTIP in patients with all PRTs related to KRAS mutational status. Methods: HomeoboxA transcript at the distal tip expression was detected in 100 PRT samples using quantitative real-time polymerase chain reaction. The associations between HOTTIP levels, clinicopathological factors, and patient prognosis were also analyzed. Results: The expression of HOTTIP was found to be significantly upregulated by 32-fold (P = 0.031) in tumor tissues compared with normal tissues. The over expression of HOTTIP was related with presence of invasion and metastasis (P = 0.0467, P = 0.0256). In addition, increased HOTTIP expression was associated with poor prognosis independent of KRAS mutation (P < 0.001; n = 72). Moreover, multivariate analysis showed that high HOTTIP expression was an unfavorable prognostic factor for overall survival. Conclusions: Our findings indicate that high levels of HOTTIP expression have the potential to be an independent, unfavorable prognostic factor for patients with PRT. | en_US |
dc.identifier.citation | Balçın, Ö. vd. (2018). ''Overexpression of the long noncoding RNA homeoboxA transcript at the distal tip predicts poor prognosis in a KRAS-independent manner in periampullary region tumors''. Pancreas, 47(2), 213-220. | en_US |
dc.identifier.endpage | 220 | tr_TR |
dc.identifier.issn | 0885-3177 | |
dc.identifier.issn | 1536-4828 | |
dc.identifier.issue | 2 | tr_TR |
dc.identifier.pubmed | 29329159 | tr_TR |
dc.identifier.scopus | 2-s2.0-85040992161 | tr_TR |
dc.identifier.startpage | 213 | tr_TR |
dc.identifier.uri | https://doi.org/10.1097/MPA.0000000000000984 | |
dc.identifier.uri | https://journals.lww.com/pancreasjournal/fulltext/2018/02000/overexpression_of_the_long_noncoding_rna_homeoboxa.10.aspx | |
dc.identifier.uri | http://hdl.handle.net/11452/34704 | |
dc.identifier.volume | 47 | tr_TR |
dc.identifier.wos | 000423205000013 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Lippincott Williams & Wilkins | en_US |
dc.relation.bap | BUAP(T)-2012/1 | tr_TR |
dc.relation.journal | Pancreas | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Gastroenterology & hepatology | en_US |
dc.subject | LncRNA | en_US |
dc.subject | HOTTIP | en_US |
dc.subject | KRAS | en_US |
dc.subject | Periampullary region tumors | en_US |
dc.subject | Prognosis | en_US |
dc.subject | Pancreatic ductal adenocarcinoma | en_US |
dc.subject | Cancer | en_US |
dc.subject | Hotair | en_US |
dc.subject | Hottip | en_US |
dc.subject | Progression | en_US |
dc.subject | Chromatin | en_US |
dc.subject | Metastasis | en_US |
dc.subject | Expression | en_US |
dc.subject | Biomarkers | en_US |
dc.subject | Evolution | en_US |
dc.subject.emtree | K ras protein | en_US |
dc.subject.emtree | Long noncoding rna homeoboxa transcript at the distal tip | en_US |
dc.subject.emtree | Long untranslated RNA | en_US |
dc.subject.emtree | Unclassified drug | en_US |
dc.subject.emtree | KRAS protein, human | en_US |
dc.subject.emtree | Long noncoding RNA HOTTIP, human | en_US |
dc.subject.emtree | Long untranslated RNA | en_US |
dc.subject.emtree | Protein p21 | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Aged | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Association | en_US |
dc.subject.emtree | Bile duct tumor | en_US |
dc.subject.emtree | Biliary tract cancer | en_US |
dc.subject.emtree | Cancer prognosis | en_US |
dc.subject.emtree | Cancer survival | en_US |
dc.subject.emtree | Clinical feature | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Distant metastasis | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Gene mutation | en_US |
dc.subject.emtree | Gene overexpression | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Human tissue | en_US |
dc.subject.emtree | Major clinical study | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Overall survival | en_US |
dc.subject.emtree | Pancreas tumor | en_US |
dc.subject.emtree | Pancreaticoduodenectomy | en_US |
dc.subject.emtree | Periampullary region tumor | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Quantitative analysis | en_US |
dc.subject.emtree | Real time polymerase chain reaction | en_US |
dc.subject.emtree | Tumor growth | en_US |
dc.subject.emtree | Tumor localization | en_US |
dc.subject.emtree | Upregulation | en_US |
dc.subject.emtree | Vater papilla tumor | en_US |
dc.subject.emtree | Gene expression regulation | en_US |
dc.subject.emtree | Genetics | en_US |
dc.subject.emtree | Kaplan meier method | en_US |
dc.subject.emtree | Middle aged | en_US |
dc.subject.emtree | Mutation | en_US |
dc.subject.emtree | Pancreas carcinoma | en_US |
dc.subject.emtree | Pathology | en_US |
dc.subject.emtree | Prognosis | en_US |
dc.subject.emtree | Very elderly | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Aged, 80 and over | en_US |
dc.subject.mesh | Carcinoma, pancreatic ductal | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gene expression regulation, neoplastic | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Kaplan-meier estimate | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.mesh | Mutation | en_US |
dc.subject.mesh | Pancreatic neoplasms | en_US |
dc.subject.mesh | Prognosis | en_US |
dc.subject.mesh | Proto-oncogene proteins p21(ras) | en_US |
dc.subject.mesh | RNA, long noncoding | en_US |
dc.subject.scopus | Microrna; Growth Arrest Specific Transcript 5; Small Nucleolar RNA | en_US |
dc.subject.wos | Gastroenterology & hepatology | en_US |
dc.title | Overexpression of the long noncoding RNA homeoboxA transcript at the distal tip predicts poor prognosis in a KRAS-independent manner in periampullary region tumors | en_US |
dc.type | Article | |
dc.wos.quartile | Q3 | en_US |
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