Glycyl-L-glutamine [beta-endorphin-(30-31)] attenuates hemorrhagic hypotension in conscious rats

dc.contributor.authorOwen, Medge D.
dc.contributor.authorZaloga, Galy P.
dc.contributor.authorMillington, William R.
dc.contributor.buuauthorGürün, Mine Sibel
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAG-8716-2019tr_TR
dc.contributor.scopusid6506970743tr_TR
dc.date.accessioned2021-09-01T07:42:32Z
dc.date.available2021-09-01T07:42:32Z
dc.date.issued1997
dc.description.abstractThe profound hypotension caused by acute hemorrhage is thought to involve opioid peptide neurons. In this study, we tested whether glycyl-L-glutamine [Gly-Gln; beta-endorphin-(30-31)], a nonopioid peptide derived from beta-endorphin processing, prevents the cardiovascular depression induced by hemorrhage in conscious and anesthetized rats. Previously, we found that Gly-GLn inhibits the hypotension and respiratory depression produced by beta-endorphin and morphine but does not affect opioid antinociception. Hemorrhage (2.5 ml/100 g body wt over 20 min) lowered arterial pressure in conscious rats (from 120.1 +/- 2.9 to 56.2 +/- 4.7 mmHg) but did not change heart rate significantly. Intracerebroventricular Gly-Gln (3, 10, or 30 nmol) pretreatment inhibited the fall in arterial pressure and increased heart rate significantly. The response was dose related and tvas sustained during the 35-min posthemorrhage interval. Pentobarbital sodium anesthesia potentiated the hemodynamic response to hemorrhage and attenuated the effect of Gly-Gln. Gig-Gin (10 or 100 nmol icy) did not influence arterial pressure or heart rate in normotensive rats. These data indicate that Gly-Gln is an effective antagonist of hemorrhagic hypotension.en_US
dc.identifier.citationOwen, M. D. vd. (1997). "Glycyl-L-glutamine [beta-endorphin-(30-31)] attenuates hemorrhagic hypotension in conscious rats". American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 273(5), 1598-1606.en_US
dc.identifier.endpage1606tr_TR
dc.identifier.issn0363-6119
dc.identifier.issue5tr_TR
dc.identifier.scopus2-s2.0-0030695377tr_TR
dc.identifier.startpage1598tr_TR
dc.identifier.urihttps://journals.physiology.org/doi/full/10.1152/ajpregu.1997.273.5.R1598
dc.identifier.urihttps://doi.org/10.1152/ajpregu.1997.273.5.r1598
dc.identifier.urihttp://hdl.handle.net/11452/21589
dc.identifier.volume273tr_TR
dc.identifier.wosA1997YF56900006tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherAmer Physiological Socen_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalAmerican Journal of Physiology-Regulatory Integrative and Comparative Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPhysiologyen_US
dc.subjectOpioiden_US
dc.subjectPosttranslational processingen_US
dc.subjectProopiomelanocortinen_US
dc.subjectDipeptideen_US
dc.subjectCardiovascularen_US
dc.subjectSympathetic-nerve activityen_US
dc.subjectBeta-endorphinen_US
dc.subjectBlood-pressureen_US
dc.subjectAlpha-mshen_US
dc.subjectCardiorespiratory depressionen_US
dc.subjectHeart-rateen_US
dc.subjectNaloxoneen_US
dc.subjectMechanismsen_US
dc.subjectNorepinephrineen_US
dc.subjectReceptorsen_US
dc.subject.emtreeBeta endorphinen_US
dc.subject.emtreeProopiomelanocortinen_US
dc.subject.emtreeAnimal cellen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArterial pressureen_US
dc.subject.emtreeHeart rateen_US
dc.subject.emtreeHemodynamicsen_US
dc.subject.emtreeHemorrhagic hypotensionen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtein processingen_US
dc.subject.emtreeProtein structureen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeRespiratory failureen_US
dc.subject.emtreeStructure activity relationen_US
dc.subject.scopusAging; Amoxicillin; Contractility Invitroen_US
dc.subject.wosPhysiologyen_US
dc.titleGlycyl-L-glutamine [beta-endorphin-(30-31)] attenuates hemorrhagic hypotension in conscious ratsen_US
dc.typeArticle

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