Glycyl-L-glutamine [beta-endorphin-(30-31)] attenuates hemorrhagic hypotension in conscious rats
dc.contributor.author | Owen, Medge D. | |
dc.contributor.author | Zaloga, Galy P. | |
dc.contributor.author | Millington, William R. | |
dc.contributor.buuauthor | Gürün, Mine Sibel | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı. | tr_TR |
dc.contributor.researcherid | AAG-8716-2019 | tr_TR |
dc.contributor.scopusid | 6506970743 | tr_TR |
dc.date.accessioned | 2021-09-01T07:42:32Z | |
dc.date.available | 2021-09-01T07:42:32Z | |
dc.date.issued | 1997 | |
dc.description.abstract | The profound hypotension caused by acute hemorrhage is thought to involve opioid peptide neurons. In this study, we tested whether glycyl-L-glutamine [Gly-Gln; beta-endorphin-(30-31)], a nonopioid peptide derived from beta-endorphin processing, prevents the cardiovascular depression induced by hemorrhage in conscious and anesthetized rats. Previously, we found that Gly-GLn inhibits the hypotension and respiratory depression produced by beta-endorphin and morphine but does not affect opioid antinociception. Hemorrhage (2.5 ml/100 g body wt over 20 min) lowered arterial pressure in conscious rats (from 120.1 +/- 2.9 to 56.2 +/- 4.7 mmHg) but did not change heart rate significantly. Intracerebroventricular Gly-Gln (3, 10, or 30 nmol) pretreatment inhibited the fall in arterial pressure and increased heart rate significantly. The response was dose related and tvas sustained during the 35-min posthemorrhage interval. Pentobarbital sodium anesthesia potentiated the hemodynamic response to hemorrhage and attenuated the effect of Gly-Gln. Gig-Gin (10 or 100 nmol icy) did not influence arterial pressure or heart rate in normotensive rats. These data indicate that Gly-Gln is an effective antagonist of hemorrhagic hypotension. | en_US |
dc.identifier.citation | Owen, M. D. vd. (1997). "Glycyl-L-glutamine [beta-endorphin-(30-31)] attenuates hemorrhagic hypotension in conscious rats". American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 273(5), 1598-1606. | en_US |
dc.identifier.endpage | 1606 | tr_TR |
dc.identifier.issn | 0363-6119 | |
dc.identifier.issue | 5 | tr_TR |
dc.identifier.scopus | 2-s2.0-0030695377 | tr_TR |
dc.identifier.startpage | 1598 | tr_TR |
dc.identifier.uri | https://journals.physiology.org/doi/full/10.1152/ajpregu.1997.273.5.R1598 | |
dc.identifier.uri | https://doi.org/10.1152/ajpregu.1997.273.5.r1598 | |
dc.identifier.uri | http://hdl.handle.net/11452/21589 | |
dc.identifier.volume | 273 | tr_TR |
dc.identifier.wos | A1997YF56900006 | tr_TR |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Amer Physiological Soc | en_US |
dc.relation.collaboration | Yurt dışı | tr_TR |
dc.relation.journal | American Journal of Physiology-Regulatory Integrative and Comparative Physiology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Physiology | en_US |
dc.subject | Opioid | en_US |
dc.subject | Posttranslational processing | en_US |
dc.subject | Proopiomelanocortin | en_US |
dc.subject | Dipeptide | en_US |
dc.subject | Cardiovascular | en_US |
dc.subject | Sympathetic-nerve activity | en_US |
dc.subject | Beta-endorphin | en_US |
dc.subject | Blood-pressure | en_US |
dc.subject | Alpha-msh | en_US |
dc.subject | Cardiorespiratory depression | en_US |
dc.subject | Heart-rate | en_US |
dc.subject | Naloxone | en_US |
dc.subject | Mechanisms | en_US |
dc.subject | Norepinephrine | en_US |
dc.subject | Receptors | en_US |
dc.subject.emtree | Beta endorphin | en_US |
dc.subject.emtree | Proopiomelanocortin | en_US |
dc.subject.emtree | Animal cell | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal tissue | en_US |
dc.subject.emtree | Arterial pressure | en_US |
dc.subject.emtree | Heart rate | en_US |
dc.subject.emtree | Hemodynamics | en_US |
dc.subject.emtree | Hemorrhagic hypotension | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Protein processing | en_US |
dc.subject.emtree | Protein structure | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Respiratory failure | en_US |
dc.subject.emtree | Structure activity relation | en_US |
dc.subject.scopus | Aging; Amoxicillin; Contractility Invitro | en_US |
dc.subject.wos | Physiology | en_US |
dc.title | Glycyl-L-glutamine [beta-endorphin-(30-31)] attenuates hemorrhagic hypotension in conscious rats | en_US |
dc.type | Article |