Role of K(v)7 potassium channels in the morphine-induced antinociception in acute and neuropathic pain
dc.contributor.author | Güleç, Güldal | |
dc.contributor.buuauthor | Kahveci, Nevzat | |
dc.contributor.buuauthor | Özlük, Kasım | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı. | tr_TR |
dc.contributor.researcherid | AAG-7070-2021 | tr_TR |
dc.contributor.scopusid | 6602597846 | tr_TR |
dc.contributor.scopusid | 6602676331 | tr_TR |
dc.date.accessioned | 2022-06-20T10:38:20Z | |
dc.date.available | 2022-06-20T10:38:20Z | |
dc.date.issued | 2011 | |
dc.description.abstract | Objective: We aimed to investigate the role of K(v)7 potassium channels in the morphine-induced antinociception in both acute and neuropathic pain models. Methods: Neuropathic pain was induced by partial ligation of the right sciatic nerve. For intracerebroventricular (i.c.v.) injections, each rat was equipped with a permanent cannula. The response to painful thermal stimuli was assessed by the tail-flick test. In sciatic nerve-ligated rats, thermal hyperalgesia was assessed by paw withdrawal latencies in the plantar test and the mechanical hyperalgesia was determined by rigid von Frey filaments. Results: Rats received morphine (2, 5, 20 mu g/10 mu l; i.c.v.) or saline (10 mu l; i.c.v.) 15 min before the tests. In all tests, morphine produced significant antinociceptive effect. When a K(v)7 potassium channel blocker, linopirdine (0.1, 1, 10 mu g/10 mu l; i.c.v.) was administered 15 min before morphine, the effect of i.c.v. morphine in the tail-flick test and plantar test but not in the test with von Frey filaments were prevented. Conclusions: K(v)7 potassium channels contribute to the effect of i.c.v. morphine on acute pain induced by thermal stimulation. In the sciatic nerve-ligated rats, these channels play role in the effect of morphine on thermal hyperalgesia, but not on mechanical hyperalgesia. | en_US |
dc.description.abstract | Akut ve nöropatik ağrı modellerinde morfine bağlı antinosisepsiyonda Kv7 potasyum kanallarının rolünü araştırmayı amaçladık. Materyal ve Metod: Nöropatik ağrı oluşturmak için sağ siyatik sinire parsiyel ligasyon uygulandı. Intraserebroventriküler (i.c.v.) enjeksiyonlar için, her sıçana kalıcı kanül takıldı. Ağrılı termal uyarana yanıt tail-flick testi ile değerlendirildi. Siyatik sinir ligasyonu yapılan sıçanlarda, termal hiperaljezi plantar testte pençe çekme latansı ile, mekanik hiperaljezi ise rijid von Frey filamanları ile değerlendirildi. Bulgular: Sıçanlara testlerden 15 dakika önce morfin (2, 5, 20 µg/10 µl; i.c.v.) veya salin (10 µl; i.c.v.) uygulandı.Tüm testlerde morfin anlamlı antinosiseptif etki gösterdi. Bir Kv7 potasyum kanal blokeri olan linopirdin (0.1, 1, 10 µg/10 µl; i.c.v.) morfinden 15 dakika önce uygulandığında, i.c.v. morfinin tail-flick ve plantar testte görülen etkilerini önlerken, von Frey filamanları ile yapılan test üzerine etkilerini değiştirmedi. Sonuç: Kv7 potasyum kanalları termal stimülasyona bağlı akut ağrıda i.c.v. morfinin etkisine katılmaktadırlar. Siyatik sinir ligasyonlu sıçanlarda, bu kanallar, morfinin termal hiperaljeziye etkisinde rol oynarken, mekanik hiperaljezi üzerine etkisinde rolü yoktur. | tr_TR |
dc.identifier.citation | Kahveci, N. vd. (2011). "Role of K(v)7 potassium channels in the morphine-induced antinociception in acute and neuropathic pain". Journal of Neurological Sciences - Turkish, 28(4), 440-452. | en_US |
dc.identifier.endpage | 452 | tr_TR |
dc.identifier.issn | 1302-1664 | |
dc.identifier.issue | 4 | tr_TR |
dc.identifier.scopus | 2-s2.0-84855544355 | tr_TR |
dc.identifier.startpage | 440 | tr_TR |
dc.identifier.uri | http://hdl.handle.net/11452/27312 | |
dc.identifier.volume | 28 | tr_TR |
dc.identifier.wos | 000300363200002 | tr_TR |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.trdizin | TrDizin | tr_TR |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Journal Neurological Sciences | en_US |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.journal | Journal of Neurological Sciences - Turkish | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Neurosciences & neurology | en_US |
dc.subject | Antinociception | en_US |
dc.subject | K(v)7 potassium channels | en_US |
dc.subject | Morphine | en_US |
dc.subject | Linopirdine | en_US |
dc.subject | Tail-flick test | en_US |
dc.subject | Plantar test | en_US |
dc.subject | von Frey filaments | en_US |
dc.subject | Rat | en_US |
dc.subject | Action-potential duration | en_US |
dc.subject | Nerve-ligation injury | en_US |
dc.subject | Induced analgesia | en_US |
dc.subject | Opioid receptors | en_US |
dc.subject | Mu-receptor | en_US |
dc.subject | Rats | en_US |
dc.subject | Pathways | en_US |
dc.subject | Model | en_US |
dc.subject | Involvement | en_US |
dc.subject | Mechanisms | en_US |
dc.subject | Morfin | en_US |
dc.subject | Antinosisepsiyon | en_US |
dc.subject | Kv7 potasyum kanalları | en_US |
dc.subject | Linopirdin | en_US |
dc.subject | Tail-flick testi | tr_TR |
dc.subject | Plantar test | tr_TR |
dc.subject | Von Frey filamanları | tr_TR |
dc.subject | Sıçan | tr_TR |
dc.subject.emtree | Linopirdine | en_US |
dc.subject.emtree | Morphine sulfate | en_US |
dc.subject.emtree | Potassium channel kv7 | en_US |
dc.subject.emtree | Unclassified drug | en_US |
dc.subject.emtree | Voltage gated potassium channel | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Antinociception | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Hyperalgesia | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Nerve ligation | en_US |
dc.subject.emtree | Neuropathic pain | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Sciatic nerve | en_US |
dc.subject.emtree | Tail flick test | en_US |
dc.subject.emtree | Thermal stimulation | en_US |
dc.subject.scopus | Cyclic GMP; Analgesic Effect; Guanylate Cyclase | en_US |
dc.subject.wos | Neurosciences | en_US |
dc.title | Role of K(v)7 potassium channels in the morphine-induced antinociception in acute and neuropathic pain | en_US |
dc.title.alternative | Akut ve nöropatik ağrıda morfine bağlı antinosisepsiyonda Kv7 potasyum kanallarının rolü | tr_TR |
dc.type | Article |