Role of K(v)7 potassium channels in the morphine-induced antinociception in acute and neuropathic pain

dc.contributor.authorGüleç, Güldal
dc.contributor.buuauthorKahveci, Nevzat
dc.contributor.buuauthorÖzlük, Kasım
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAG-7070-2021tr_TR
dc.contributor.scopusid6602597846tr_TR
dc.contributor.scopusid6602676331tr_TR
dc.date.accessioned2022-06-20T10:38:20Z
dc.date.available2022-06-20T10:38:20Z
dc.date.issued2011
dc.description.abstractObjective: We aimed to investigate the role of K(v)7 potassium channels in the morphine-induced antinociception in both acute and neuropathic pain models. Methods: Neuropathic pain was induced by partial ligation of the right sciatic nerve. For intracerebroventricular (i.c.v.) injections, each rat was equipped with a permanent cannula. The response to painful thermal stimuli was assessed by the tail-flick test. In sciatic nerve-ligated rats, thermal hyperalgesia was assessed by paw withdrawal latencies in the plantar test and the mechanical hyperalgesia was determined by rigid von Frey filaments. Results: Rats received morphine (2, 5, 20 mu g/10 mu l; i.c.v.) or saline (10 mu l; i.c.v.) 15 min before the tests. In all tests, morphine produced significant antinociceptive effect. When a K(v)7 potassium channel blocker, linopirdine (0.1, 1, 10 mu g/10 mu l; i.c.v.) was administered 15 min before morphine, the effect of i.c.v. morphine in the tail-flick test and plantar test but not in the test with von Frey filaments were prevented. Conclusions: K(v)7 potassium channels contribute to the effect of i.c.v. morphine on acute pain induced by thermal stimulation. In the sciatic nerve-ligated rats, these channels play role in the effect of morphine on thermal hyperalgesia, but not on mechanical hyperalgesia.en_US
dc.description.abstractAkut ve nöropatik ağrı modellerinde morfine bağlı antinosisepsiyonda Kv7 potasyum kanallarının rolünü araştırmayı amaçladık. Materyal ve Metod: Nöropatik ağrı oluşturmak için sağ siyatik sinire parsiyel ligasyon uygulandı. Intraserebroventriküler (i.c.v.) enjeksiyonlar için, her sıçana kalıcı kanül takıldı. Ağrılı termal uyarana yanıt tail-flick testi ile değerlendirildi. Siyatik sinir ligasyonu yapılan sıçanlarda, termal hiperaljezi plantar testte pençe çekme latansı ile, mekanik hiperaljezi ise rijid von Frey filamanları ile değerlendirildi. Bulgular: Sıçanlara testlerden 15 dakika önce morfin (2, 5, 20 µg/10 µl; i.c.v.) veya salin (10 µl; i.c.v.) uygulandı.Tüm testlerde morfin anlamlı antinosiseptif etki gösterdi. Bir Kv7 potasyum kanal blokeri olan linopirdin (0.1, 1, 10 µg/10 µl; i.c.v.) morfinden 15 dakika önce uygulandığında, i.c.v. morfinin tail-flick ve plantar testte görülen etkilerini önlerken, von Frey filamanları ile yapılan test üzerine etkilerini değiştirmedi. Sonuç: Kv7 potasyum kanalları termal stimülasyona bağlı akut ağrıda i.c.v. morfinin etkisine katılmaktadırlar. Siyatik sinir ligasyonlu sıçanlarda, bu kanallar, morfinin termal hiperaljeziye etkisinde rol oynarken, mekanik hiperaljezi üzerine etkisinde rolü yoktur.tr_TR
dc.identifier.citationKahveci, N. vd. (2011). "Role of K(v)7 potassium channels in the morphine-induced antinociception in acute and neuropathic pain". Journal of Neurological Sciences - Turkish, 28(4), 440-452.en_US
dc.identifier.endpage452tr_TR
dc.identifier.issn1302-1664
dc.identifier.issue4tr_TR
dc.identifier.scopus2-s2.0-84855544355tr_TR
dc.identifier.startpage440tr_TR
dc.identifier.urihttp://hdl.handle.net/11452/27312
dc.identifier.volume28tr_TR
dc.identifier.wos000300363200002tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.trdizinTrDizintr_TR
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherJournal Neurological Sciencesen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalJournal of Neurological Sciences - Turkishen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectAntinociceptionen_US
dc.subjectK(v)7 potassium channelsen_US
dc.subjectMorphineen_US
dc.subjectLinopirdineen_US
dc.subjectTail-flick testen_US
dc.subjectPlantar testen_US
dc.subjectvon Frey filamentsen_US
dc.subjectRaten_US
dc.subjectAction-potential durationen_US
dc.subjectNerve-ligation injuryen_US
dc.subjectInduced analgesiaen_US
dc.subjectOpioid receptorsen_US
dc.subjectMu-receptoren_US
dc.subjectRatsen_US
dc.subjectPathwaysen_US
dc.subjectModelen_US
dc.subjectInvolvementen_US
dc.subjectMechanismsen_US
dc.subjectMorfinen_US
dc.subjectAntinosisepsiyonen_US
dc.subjectKv7 potasyum kanallarıen_US
dc.subjectLinopirdinen_US
dc.subjectTail-flick testitr_TR
dc.subjectPlantar testtr_TR
dc.subjectVon Frey filamanlarıtr_TR
dc.subjectSıçantr_TR
dc.subject.emtreeLinopirdineen_US
dc.subject.emtreeMorphine sulfateen_US
dc.subject.emtreePotassium channel kv7en_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeVoltage gated potassium channelen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAntinociceptionen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeHyperalgesiaen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNerve ligationen_US
dc.subject.emtreeNeuropathic painen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSciatic nerveen_US
dc.subject.emtreeTail flick testen_US
dc.subject.emtreeThermal stimulationen_US
dc.subject.scopusCyclic GMP; Analgesic Effect; Guanylate Cyclaseen_US
dc.subject.wosNeurosciencesen_US
dc.titleRole of K(v)7 potassium channels in the morphine-induced antinociception in acute and neuropathic painen_US
dc.title.alternativeAkut ve nöropatik ağrıda morfine bağlı antinosisepsiyonda Kv7 potasyum kanallarının rolütr_TR
dc.typeArticle

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