Solid lipid nanoparticles in reversing the acquired tamoxifen-resistance

dc.contributor.authorEskiler, Gamze Güney
dc.contributor.buuauthorÇeçener, Gülşah
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorTunca, Berrin
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-3820-424Xtr_TR
dc.contributor.orcid0000-0001-7904-883Xtr_TR
dc.contributor.orcid0000-0002-1619-6680tr_TR
dc.contributor.researcheridAAP-9988-2020tr_TR
dc.contributor.researcheridAAH-1420-2021tr_TR
dc.contributor.researcheridABI-6078-2020tr_TR
dc.contributor.scopusid6508156530tr_TR
dc.contributor.scopusid55665145000tr_TR
dc.contributor.scopusid6602965754tr_TR
dc.date.accessioned2023-09-19T11:33:33Z
dc.date.available2023-09-19T11:33:33Z
dc.date.issued2017
dc.descriptionBu çalışma, 22-24 Haziran, 2017 tarihlerinde Sinaia[Romanya]’da düzenlenen 6. IEEE International Conference on E-Health and Bioengineering (EHB) Kongresi‘nde bildiri olarak sunulmuştur.tr_TR
dc.description.abstractThe anti-estrogen tamoxifen (Tam) is the most preferred option for patients with estrogen-receptor (ER)-positive breast cancer. However, multi-drug resistance (MDR) is a considerable clinical problem in the successful chemotherapeutic treatment. Members of the ATP-binding cassette (ABC) transporter family proteins play an important role in acquired drug resistance. Many studies have focused primarily on the clinical significance of P-gp (MDR1), BCRP and MRP1 members belong to ABC transporter superfamily on anticancer-drug resistance. Consequently, several strategies have been improved to overcome drug resistance. Nanoparticle drug delivery systems provide an increase in the intracellular concentration of the drugs as well as a reduction in toxicity of free-drug on healthy cells thanks to unique physical and biological properties. Solid lipid nanoparticles (SLNs) have been improved as an alternative colloidal drug delivery systems due to successful incorporation of both hydrophilic and hydrophobic compounds and their related benefits (controlled drug release, high entrapment efficiency and small size etc.) For this purpose, the aim of this study was to discuss the role of Tam-loaded solid lipid nanoparticles (SLNs) to overcome MDR and determine the ability of Tam-SLNs to induce apoptosis.en_US
dc.description.sponsorshipIEEEen_US
dc.description.sponsorshipIEEE EMBen_US
dc.description.sponsorshipRomania Chapteren_US
dc.description.sponsorshipRomanian Acad, Iasi Branch, Inst Comp Scien_US
dc.description.sponsorshipGrigore T Popa Univ Med & Pharmacyen_US
dc.description.sponsorshipIEEE Romania Secten_US
dc.description.sponsorshipInst Informatica Teoreticaen_US
dc.description.sponsorshipESC Working Grp e Cardiolen_US
dc.description.sponsorshipRomanian Soc Med Bioengineeringen_US
dc.description.sponsorshipGrigore T Popa Univ Med & Pharmacyen_US
dc.description.sponsorshipFac Med Bioengineeringen_US
dc.description.sponsorshipIEEE EMC Romania Chapteren_US
dc.identifier.citationEskiler, G. G. vd. (2017). ''Solid lipid nanoparticles in reversing the acquired tamoxifen-resistance''. E-Health and Bioengineering Conference, 2017 IEEE international conference on e-health and bioengineering conference (EHB), 177-180.en_US
dc.identifier.endpage180tr_TR
dc.identifier.isbn978-1-5386-0358-1
dc.identifier.issn2575-5137
dc.identifier.issn2575-5145
dc.identifier.scopus2-s2.0-85028523742tr_TR
dc.identifier.startpage177tr_TR
dc.identifier.urihttp://hdl.handle.net/11452/33902
dc.identifier.wos000445457500045tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.wosCPCISen_US
dc.language.isoenen_US
dc.publisherIEEEen_US
dc.relation.bapOUAP(T)-2014/30tr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.journalE-Health and Bioengineering Conference, 2017 IEEE international conference on e-health and bioengineering conference (EHB)en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararasıtr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectComputer scienceen_US
dc.subjectEngineeringen_US
dc.subjectMedical informaticsen_US
dc.subjectBreast canceren_US
dc.subjectTamoxifenen_US
dc.subjectMulti-drug resistance (MDR)en_US
dc.subjectNanoparticle drug delivery systemsen_US
dc.subjectSolid lipid nanoparticles (SLNs)en_US
dc.subjectOf-the-arten_US
dc.subjectBreast-canceren_US
dc.subjectDrug-deliveryen_US
dc.subjectCell deathen_US
dc.subjectDiseasesen_US
dc.subjectDrug therapyen_US
dc.subjectElectric resistanceen_US
dc.subjectHydrophobicityen_US
dc.subjectNanoparticlesen_US
dc.subjectBreast canceren_US
dc.subjectDrug delivery systemen_US
dc.subjectMultidrug resistanceen_US
dc.subjectSolid lipid nanoparticlesen_US
dc.subjectTamoxifenen_US
dc.subjectControlled drug deliveryen_US
dc.subject.scopusBreast Neoplasms; Aromatase Inhibitors; Estrogen Receptorsen_US
dc.subject.wosComputer science, interdisciplinary applicationsen_US
dc.subject.wosEngineering, biomedicalen_US
dc.subject.wosMedical informaticsen_US
dc.titleSolid lipid nanoparticles in reversing the acquired tamoxifen-resistanceen_US
dc.typeProceedings Paper

Files

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: