Lipopolysaccharide-induced hypotension is mediated by a neural pathway involving the vagus nerve, the nucleus tractus solitarius and alpha-adrenergic receptors in the preoptic anterior hypothalamic area

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dc.contributor.authorMillington, William
dc.contributor.authorMyer, Brian
dc.contributor.authorCutrera, Rodolfo
dc.contributor.authorFeleder, Carlos
dc.contributor.buuauthorYılmaz, Mustafa Sertaç
dc.contributor.buuauthorGöktalay, Gökhan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-9496-1475tr_TR
dc.contributor.researcheridAAH-1571-2021tr_TR
dc.contributor.researcheridAAH-1448-2021tr_TR
dc.contributor.scopusid8895544100tr_TR
dc.contributor.scopusid6508023759tr_TR
dc.date.accessioned2022-03-14T12:15:29Z
dc.date.available2022-03-14T12:15:29Z
dc.date.issued2008-10-15
dc.description.abstractWe recently reported that the preoptic anterior hypothalamic area (POA) mediates the hypotensive response evoked by lipopolysaccharide (LPS). In this study, we investigated how the inflammatory signal induced by Lips reaches the POA. Subdiaphragmatic vagotomy and abdominal perivagal lidocaine administration, or lidocaine injection into the nucleus tractus solitarius (NTS) prevented LPS hypotension. Microinjection of the alpha-adrenergic receptor antagonist phentolamine into the POA, blocked initiation of the hypotensive response and prevented the late decompensatory phase. These data suggest that LPS hypotension is mediated by the vagus nerve which conveys the signal to the NTS and, in turn, stimulates norepinephrine release within the POA.tr_TR
dc.description.sponsorshipAlbany College of Pharmacyen_US
dc.identifier.citationYılmaz, M.S. vd. (2008). ''Lipopolysaccharide-induced hypotension is mediated by a neural pathway involving the vagus nerve, the nucleus tractus solitarius and alpha-adrenergic receptors in the preoptic anterior hypothalamic area''. Journal of Neuroimmunology, 203(1), 39-49.en_US
dc.identifier.endpage49tr_TR
dc.identifier.issn0165-5728
dc.identifier.issn1872-8421
dc.identifier.issue1tr_TR
dc.identifier.pubmed18653249tr_TR
dc.identifier.scopus2-s2.0-52949137864tr_TR
dc.identifier.startpage39tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.jneuroim.2008.06.023
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S016557280800249X
dc.identifier.urihttp://hdl.handle.net/11452/24998
dc.identifier.volume203tr_TR
dc.identifier.wos000260695200006tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalJournal of Neuroimmunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlpha-adrenergic receptorsen_US
dc.subjectEndotoxic shocken_US
dc.subjectHypotensionen_US
dc.subjectNucleus tractus solitariusen_US
dc.subjectVagus nerveen_US
dc.subjectTumor-necrosis-factoren_US
dc.subjectC-fos expressionen_US
dc.subjectSubdiaphragmatic vagotomyen_US
dc.subjectNitric-oxideen_US
dc.subjectTnf-alphaen_US
dc.subjectBody-temperatureen_US
dc.subjectEndotoxic feveren_US
dc.subjectGuinea-pigsen_US
dc.subjectCytokinesen_US
dc.subjectRaten_US
dc.subject.emtreeAlpha adrenergic receptoren_US
dc.subject.emtreeLidocaineen_US
dc.subject.emtreeLipopolysaccharideen_US
dc.subject.emtreeNoradrenalinen_US
dc.subject.emtreePhentolamineen_US
dc.subject.emtreePropranololen_US
dc.subject.emtreeAdrenergic systemen_US
dc.subject.emtreeAdrenergic transmissionen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeAnterior hypothalamusen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeHypotensionen_US
dc.subject.emtreeImmune responseen_US
dc.subject.emtreeInflammationen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNeuropathologyen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeNoradrenalin releaseen_US
dc.subject.emtreePharmacological blockingen_US
dc.subject.emtreePreoptic areaen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSolitary tract nucleusen_US
dc.subject.emtreeVagotomyen_US
dc.subject.emtreeVagus nerveen_US
dc.subject.meshAcute diseaseen_US
dc.subject.meshAdrenergic alpha-antagonistsen_US
dc.subject.meshAnesthetics, localen_US
dc.subject.meshAnimalsen_US
dc.subject.meshHypotensionen_US
dc.subject.meshLidocaineen_US
dc.subject.meshLipopolysaccharidesen_US
dc.subject.meshMaleen_US
dc.subject.meshPhentolamineen_US
dc.subject.meshPreoptic -areaen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-Dawleden_US
dc.subject.meshReceptors, adrenergic, alphaen_US
dc.subject.meshShock, septicen_US
dc.subject.meshSignal transductionen_US
dc.subject.meshSolitary nucleusen_US
dc.subject.meshVagotomyen_US
dc.subject.meshVagus nerveen_US
dc.subject.scopusIllness Behavior; Leukocyte Endogenous Mediator; Antipyreticsen_US
dc.subject.wosImmunologyen_US
dc.subject.wosNeurosciencesen_US
dc.titleLipopolysaccharide-induced hypotension is mediated by a neural pathway involving the vagus nerve, the nucleus tractus solitarius and alpha-adrenergic receptors in the preoptic anterior hypothalamic areaen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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