Apoptosis-inducing effect of a palladium(II) saccharinate complex of terpyridine on human breast cancer cells in vitro and in vivo
dc.contributor.author | İkitimur, Elif Armutak | |
dc.contributor.buuauthor | Arı, Ferda | |
dc.contributor.buuauthor | Cevatemre, Buse | |
dc.contributor.buuauthor | Aztopal, Nazlıhan | |
dc.contributor.buuauthor | Yılmaz, Veysel Turan | |
dc.contributor.buuauthor | Ulukaya, Engin | |
dc.contributor.department | Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0003-3118-8061 | tr_TR |
dc.contributor.orcid | 0000-0002-2849-3332 | tr_TR |
dc.contributor.orcid | 0000-0002-6729-7908 | tr_TR |
dc.contributor.orcid | 0000-0002-7359-6568 | tr_TR |
dc.contributor.researcherid | L-6687-2018 | tr_TR |
dc.contributor.researcherid | K-5792-2018 | tr_TR |
dc.contributor.researcherid | L-7238-2018 | tr_TR |
dc.contributor.researcherid | AAG-7012-2021 | tr_TR |
dc.contributor.researcherid | D-2901-2019 | tr_TR |
dc.contributor.scopusid | 24376085300 | tr_TR |
dc.contributor.scopusid | 55693788600 | tr_TR |
dc.contributor.scopusid | 55853882900 | tr_TR |
dc.contributor.scopusid | 7006269202 | tr_TR |
dc.contributor.scopusid | 6602927353 | tr_TR |
dc.date.accessioned | 2022-09-06T06:25:41Z | |
dc.date.available | 2022-09-06T06:25:41Z | |
dc.date.issued | 2014-09-01 | |
dc.description.abstract | The anti-growth effect of a palladium(II) complex-[PdCl(terpy)](sac)center dot 2H(2)O] (sac = saccharinate, and terpy = 2,2':6',2 ''-terpyridine)-was tested against human breast cancer cell lines, MCF-7 and MDA-MB-231. Anti-growth effect was assayed by the MTT and ATP viability assays in vitro and then confirmed on Balb/c mice in vivo. The mode of cell death was determined by both histological and biochemical methods. The Pd(II) complex had anti-growth effect on a dose dependent manner in vitro and in vivo. The cells died by apoptosis as evidenced by the pyknotic nucleus, cleavage of poly-(ADP-ribose) polymerase (PARP) and induction of active caspase-3. These results suggest that the palladium(II) saccharinate complex of terpyridine represents a potentially active novel complex for the breast cancer treatment, thus warrants further studies. | en_US |
dc.description.sponsorship | İstanbul Üniversitesi (30869) | tr_TR |
dc.identifier.citation | Arı, F. vd. (2014). "Apoptosis-inducing effect of a palladium(II) saccharinate complex of terpyridine on human breast cancer cells in vitro and in vivo". Bioorganic and Medicinal Chemistry, 22(17), 4948-4954. | en_US |
dc.identifier.endpage | 4954 | tr_TR |
dc.identifier.issn | 0968-0896 | |
dc.identifier.issn | 1464-3391 | |
dc.identifier.issue | 17 | tr_TR |
dc.identifier.pubmed | 25047941 | tr_TR |
dc.identifier.scopus | 2-s2.0-84906934164 | tr_TR |
dc.identifier.startpage | 4948 | tr_TR |
dc.identifier.uri | https://doi.org/10.1016/j.bmc.2014.06.039 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0968089614004854 | |
dc.identifier.uri | http://hdl.handle.net/11452/28484 | |
dc.identifier.volume | 22 | tr_TR |
dc.identifier.wos | 000341293300044 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Pergamon-Elsevier Science | en_US |
dc.relation.bap | UAP(F)-2011/41 | tr_TR |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.journal | Bioorganic and Medicinal Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Palladium(II) complex | en_US |
dc.subject | Breast cancer | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Cytotoxicity | en_US |
dc.subject | PD(II) complexes | en_US |
dc.subject | DNA binding | en_US |
dc.subject | Death | en_US |
dc.subject | Caspase-3 | en_US |
dc.subject | Cleavage | en_US |
dc.subject | CU(II) | en_US |
dc.subject | PT(II) | en_US |
dc.subject | Assay | en_US |
dc.subject | Biochemistry & molecular biology | en_US |
dc.subject | Pharmacology & pharmacy | en_US |
dc.subject | Chemistry | en_US |
dc.subject | Mus | en_US |
dc.subject.emtree | Adenosine triphosphate | en_US |
dc.subject.emtree | Antineoplastic agent | en_US |
dc.subject.emtree | Caspase 3 | en_US |
dc.subject.emtree | Cisplatin | en_US |
dc.subject.emtree | Nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase | en_US |
dc.subject.emtree | Paclitaxel | en_US |
dc.subject.emtree | Palladium complex | en_US |
dc.subject.emtree | Palladium saccharinate complex | en_US |
dc.subject.emtree | Unclassified drug | en_US |
dc.subject.emtree | Antineoplastic agent | en_US |
dc.subject.emtree | Coordination compound | en_US |
dc.subject.emtree | Palladium | en_US |
dc.subject.emtree | Pyridine derivative | en_US |
dc.subject.emtree | Saccharin | en_US |
dc.subject.emtree | Animal cell | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Animal tissue | en_US |
dc.subject.emtree | Antineoplastic activity | en_US |
dc.subject.emtree | Apoptosis | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Biochemistry | en_US |
dc.subject.emtree | Breast cancer | en_US |
dc.subject.emtree | Cancer cell | en_US |
dc.subject.emtree | Cancer inhibition | en_US |
dc.subject.emtree | Cell assay | en_US |
dc.subject.emtree | Cell nucleus | en_US |
dc.subject.emtree | Cell strain | en_US |
dc.subject.emtree | Cell strain MDA MB 231 | en_US |
dc.subject.emtree | Concentration response | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Dose response | en_US |
dc.subject.emtree | Drug structure | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Histopathology | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Human cell | en_US |
dc.subject.emtree | In vitro study | en_US |
dc.subject.emtree | In vivo study | en_US |
dc.subject.emtree | MCF 7 cell line | en_US |
dc.subject.emtree | Mouse | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Protein cleavage | en_US |
dc.subject.emtree | Analogs and derivatives | en_US |
dc.subject.emtree | Animal | en_US |
dc.subject.emtree | Apoptosis | en_US |
dc.subject.emtree | Bagg albino mouse | en_US |
dc.subject.emtree | Breast neoplasms | en_US |
dc.subject.emtree | Cell proliferation | en_US |
dc.subject.emtree | Cell survival | en_US |
dc.subject.emtree | Chemical structure | en_US |
dc.subject.emtree | Chemistry | en_US |
dc.subject.emtree | Drug effects | en_US |
dc.subject.emtree | Drug screening | en_US |
dc.subject.emtree | Pathology | en_US |
dc.subject.emtree | Structure activity relation | en_US |
dc.subject.emtree | Synthesis | en_US |
dc.subject.emtree | Tumor cell culture | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Antineoplastic agents | en_US |
dc.subject.mesh | Apoptosis | en_US |
dc.subject.mesh | Breast neoplasms | en_US |
dc.subject.mesh | Cell proliferation | en_US |
dc.subject.mesh | Cell survival | en_US |
dc.subject.mesh | Coordination complexes | en_US |
dc.subject.mesh | Dose-response relationship, drug | en_US |
dc.subject.mesh | Drug screening assays, antitumor | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | MCF-7 Cells | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Mice, inbred BALB C | en_US |
dc.subject.mesh | Molecular structure | en_US |
dc.subject.mesh | Palladium | en_US |
dc.subject.mesh | Pyridines | en_US |
dc.subject.mesh | Saccharin | en_US |
dc.subject.mesh | Structure-activity relationship | en_US |
dc.subject.mesh | Tumor cells, cultured | en_US |
dc.subject.scopus | Complex; Palladium; 2-Phenylpyridine | en_US |
dc.subject.wos | Biochemistry & molecular biology | en_US |
dc.subject.wos | Chemistry, medicinal | en_US |
dc.subject.wos | Chemistry, organic | en_US |
dc.title | Apoptosis-inducing effect of a palladium(II) saccharinate complex of terpyridine on human breast cancer cells in vitro and in vivo | en_US |
dc.type | Article | |
dc.wos.quartile | Q2 | en_US |
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