Apoptosis-inducing effect of a palladium(II) saccharinate complex of terpyridine on human breast cancer cells in vitro and in vivo

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dc.contributor.authorİkitimur, Elif Armutak
dc.contributor.buuauthorArı, Ferda
dc.contributor.buuauthorCevatemre, Buse
dc.contributor.buuauthorAztopal, Nazlıhan
dc.contributor.buuauthorYılmaz, Veysel Turan
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-3118-8061tr_TR
dc.contributor.orcid0000-0002-2849-3332tr_TR
dc.contributor.orcid0000-0002-6729-7908tr_TR
dc.contributor.orcid0000-0002-7359-6568tr_TR
dc.contributor.researcheridL-6687-2018tr_TR
dc.contributor.researcheridK-5792-2018tr_TR
dc.contributor.researcheridL-7238-2018tr_TR
dc.contributor.researcheridAAG-7012-2021tr_TR
dc.contributor.researcheridD-2901-2019tr_TR
dc.contributor.scopusid24376085300tr_TR
dc.contributor.scopusid55693788600tr_TR
dc.contributor.scopusid55853882900tr_TR
dc.contributor.scopusid7006269202tr_TR
dc.contributor.scopusid6602927353tr_TR
dc.date.accessioned2022-09-06T06:25:41Z
dc.date.available2022-09-06T06:25:41Z
dc.date.issued2014-09-01
dc.description.abstractThe anti-growth effect of a palladium(II) complex-[PdCl(terpy)](sac)center dot 2H(2)O] (sac = saccharinate, and terpy = 2,2':6',2 ''-terpyridine)-was tested against human breast cancer cell lines, MCF-7 and MDA-MB-231. Anti-growth effect was assayed by the MTT and ATP viability assays in vitro and then confirmed on Balb/c mice in vivo. The mode of cell death was determined by both histological and biochemical methods. The Pd(II) complex had anti-growth effect on a dose dependent manner in vitro and in vivo. The cells died by apoptosis as evidenced by the pyknotic nucleus, cleavage of poly-(ADP-ribose) polymerase (PARP) and induction of active caspase-3. These results suggest that the palladium(II) saccharinate complex of terpyridine represents a potentially active novel complex for the breast cancer treatment, thus warrants further studies.en_US
dc.description.sponsorshipİstanbul Üniversitesi (30869)tr_TR
dc.identifier.citationArı, F. vd. (2014). "Apoptosis-inducing effect of a palladium(II) saccharinate complex of terpyridine on human breast cancer cells in vitro and in vivo". Bioorganic and Medicinal Chemistry, 22(17), 4948-4954.en_US
dc.identifier.endpage4954tr_TR
dc.identifier.issn0968-0896
dc.identifier.issn1464-3391
dc.identifier.issue17tr_TR
dc.identifier.pubmed25047941tr_TR
dc.identifier.scopus2-s2.0-84906934164tr_TR
dc.identifier.startpage4948tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2014.06.039
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0968089614004854
dc.identifier.urihttp://hdl.handle.net/11452/28484
dc.identifier.volume22tr_TR
dc.identifier.wos000341293300044tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Scienceen_US
dc.relation.bapUAP(F)-2011/41tr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.journalBioorganic and Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPalladium(II) complexen_US
dc.subjectBreast canceren_US
dc.subjectApoptosisen_US
dc.subjectCytotoxicityen_US
dc.subjectPD(II) complexesen_US
dc.subjectDNA bindingen_US
dc.subjectDeathen_US
dc.subjectCaspase-3en_US
dc.subjectCleavageen_US
dc.subjectCU(II)en_US
dc.subjectPT(II)en_US
dc.subjectAssayen_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectChemistryen_US
dc.subjectMusen_US
dc.subject.emtreeAdenosine triphosphateen_US
dc.subject.emtreeAntineoplastic agenten_US
dc.subject.emtreeCaspase 3en_US
dc.subject.emtreeCisplatinen_US
dc.subject.emtreeNicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferaseen_US
dc.subject.emtreePaclitaxelen_US
dc.subject.emtreePalladium complexen_US
dc.subject.emtreePalladium saccharinate complexen_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeAntineoplastic agenten_US
dc.subject.emtreeCoordination compounden_US
dc.subject.emtreePalladiumen_US
dc.subject.emtreePyridine derivativeen_US
dc.subject.emtreeSaccharinen_US
dc.subject.emtreeAnimal cellen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeAntineoplastic activityen_US
dc.subject.emtreeApoptosisen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBiochemistryen_US
dc.subject.emtreeBreast canceren_US
dc.subject.emtreeCancer cellen_US
dc.subject.emtreeCancer inhibitionen_US
dc.subject.emtreeCell assayen_US
dc.subject.emtreeCell nucleusen_US
dc.subject.emtreeCell strainen_US
dc.subject.emtreeCell strain MDA MB 231en_US
dc.subject.emtreeConcentration responseen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDose responseen_US
dc.subject.emtreeDrug structureen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeIn vitro studyen_US
dc.subject.emtreeIn vivo studyen_US
dc.subject.emtreeMCF 7 cell lineen_US
dc.subject.emtreeMouseen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeProtein cleavageen_US
dc.subject.emtreeAnalogs and derivativesen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeApoptosisen_US
dc.subject.emtreeBagg albino mouseen_US
dc.subject.emtreeBreast neoplasmsen_US
dc.subject.emtreeCell proliferationen_US
dc.subject.emtreeCell survivalen_US
dc.subject.emtreeChemical structureen_US
dc.subject.emtreeChemistryen_US
dc.subject.emtreeDrug effectsen_US
dc.subject.emtreeDrug screeningen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreeStructure activity relationen_US
dc.subject.emtreeSynthesisen_US
dc.subject.emtreeTumor cell cultureen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntineoplastic agentsen_US
dc.subject.meshApoptosisen_US
dc.subject.meshBreast neoplasmsen_US
dc.subject.meshCell proliferationen_US
dc.subject.meshCell survivalen_US
dc.subject.meshCoordination complexesen_US
dc.subject.meshDose-response relationship, drugen_US
dc.subject.meshDrug screening assays, antitumoren_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMCF-7 Cellsen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, inbred BALB Cen_US
dc.subject.meshMolecular structureen_US
dc.subject.meshPalladiumen_US
dc.subject.meshPyridinesen_US
dc.subject.meshSaccharinen_US
dc.subject.meshStructure-activity relationshipen_US
dc.subject.meshTumor cells, cultureden_US
dc.subject.scopusComplex; Palladium; 2-Phenylpyridineen_US
dc.subject.wosBiochemistry & molecular biologyen_US
dc.subject.wosChemistry, medicinalen_US
dc.subject.wosChemistry, organicen_US
dc.titleApoptosis-inducing effect of a palladium(II) saccharinate complex of terpyridine on human breast cancer cells in vitro and in vivoen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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