Long-term outcome of the fetal adrenal gland transplantation in rats

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dc.contributor.buuauthorKiriştioğlu, İrfan
dc.contributor.buuauthorDoğruyol, Hasan
dc.contributor.buuauthorÇavuşoğlu, İlkin
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Çocuk Cerrahisi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.tr_TR
dc.contributor.scopusid21645753900tr_TR
dc.contributor.scopusid7003752033tr_TR
dc.contributor.scopusid56009155800tr_TR
dc.date.accessioned2021-12-17T08:44:49Z
dc.date.available2021-12-17T08:44:49Z
dc.date.issued1999-12
dc.description.abstractThree experimental groups have been constructed to evaluate the long-term outcome of fetal adrenal transplantation in rats. In Group 1 (n = 10), rats underwent bilateral adrenalectomy. In Group 2 (n = 10), rats underwent a sham procedure which included flank incision and arterial canulization. In Group 3 (n = 20), a left adrenalectomy was performed followed immediately by transplantation of a fetal adrenal graft into the greater omentum and marked with a prolene suture (Stage 1). One year later, the right adrenal gland of the recipient was removed followed by a determination of the fetal adrenal graft function (Stage 2). Craft function was evaluated by measuring ACTH and corticosterone levels; and a histologic examination of the transplanted fetal adrenal gland was obtained at autopsy. In Group 1, all the rats died within first 8 hours, following bilateral adrenalectomy. In Group 2, and Group 3, all rats survived after Stage 1 operation. During the Stage 2 operation, it was observed that three rats (15 %) had neither fetal adrenal transplant nor prolene suture, seven rats (35 %) had a well vascularized and developed fetal adrenal graft and a prolene suture. There was no visible fetal adrenal graft but the prolene suture was present in the remaining rats (50 %) in Group 3. After removal of the right adrenal gland (6 and 12 hours later), the mean plasma level of ACTH increased with a decline in mean serum corticosterone level in Group 3 compared to the sham-operated animals (p < 0.001). In spite of visible, and viable transplants, all rats died within 48 hours following Stage 2 operation. The mean weight of the fetal adrenal transplant showed a sixteen-fold increase compared to the initial weight (p < 0.001) and histologic examination showed all 3 zones of adrenal cortex, but there were no medullary cells noted. Although the transplanted fetal adrenal grafts survived, their hormonal function was not enough to maintain host viability. Based on these results it is concluded that, insufficiency of the transplanted fetal adrenal gland may be secondary to either graft rejection or suppression of the transplanted tissue by the functional recipient adrenal despite the fetal adrenal transplant survival.en_US
dc.identifier.citationKiriştioğlu, İ. vd. (1999). "Long-term outcome of the fetal adrenal gland transplantation in rats". European Journal of Pediatric Surgery, 9(6), 400-405.en_US
dc.identifier.endpage405tr_TR
dc.identifier.issn0939-7248
dc.identifier.issue6tr_TR
dc.identifier.pubmed10661852tr_TR
dc.identifier.startpage400tr_TR
dc.identifier.urihttps://doi.org/10.1055/s-2008-1072292
dc.identifier.urihttps://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-2008-1072292
dc.identifier.urihttp://hdl.handle.net/11452/23356
dc.identifier.volume9tr_TR
dc.identifier.wos000084619200011tr_TR
dc.indexed.pubmedPubmeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlagen_US
dc.relation.journalEuropean Journal of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPediatricsen_US
dc.subjectSurgeryen_US
dc.subjectTransplantationen_US
dc.subjectAdrenal graftsen_US
dc.subjectFetalen_US
dc.subjectRaten_US
dc.subjectLong-term outcomeen_US
dc.subjectTissueen_US
dc.subject.emtreeAdrenal functionen_US
dc.subject.emtreeAdrenal glanden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAutopsyen_US
dc.subject.emtreeFetusen_US
dc.subject.emtreeGraft survivalen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeOrgan transplantationen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSurvival rateen_US
dc.subject.scopusAdrenal Cortex; Hypothalamic Hormones; Adrenalectomyen_US
dc.subject.wosPediatricsen_US
dc.subject.wosSurgeryen_US
dc.titleLong-term outcome of the fetal adrenal gland transplantation in ratsen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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