Impact of menthol on oral nicotine consumption in female and male sprague dawley rats
dc.contributor.author | Bağdaş, Deniz | |
dc.contributor.author | Gül, Zülfiye | |
dc.contributor.author | Scott, Michael M. | |
dc.contributor.author | Tyndale, Rachel F. | |
dc.contributor.author | Damaj, M. Imad | |
dc.contributor.buuauthor | Cam, Betül | |
dc.contributor.buuauthor | Büyükuysal, Levent | |
dc.contributor.buuauthor | Gürün, Mine Sibel | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı. | tr_TR |
dc.contributor.researcherid | AAH-1657-2021 | tr_TR |
dc.contributor.researcherid | CGO-3719-2022 | tr_TR |
dc.contributor.researcherid | DVX-8040-2022 | tr_TR |
dc.contributor.scopusid | 56427863700 | tr_TR |
dc.contributor.scopusid | 6602686612 | tr_TR |
dc.contributor.scopusid | 55664349700 | tr_TR |
dc.date.accessioned | 2023-01-30T08:46:11Z | |
dc.date.available | 2023-01-30T08:46:11Z | |
dc.date.issued | 2019-02-05 | |
dc.description.abstract | Introduction: One of the preferable flavors in oral nicotine delivery systems is menthol which masks the harshness of tobacco. However, possible interactions between oral menthol and nicotine on intake and preference remain unclear. Therefore, we aimed to determine the impact of menthol on oral nicotine consumption. Methods: Adult Sprague Dawley female and male rats (n = 8 per group) were given a choice of water or drug solution by using two-bottle free choice paradigm for 2 weeks: vehicle (5% ethanol), nicotine (20 mg/L), menthol (1 g/L) and mentholated nicotine groups. At the end of the study, plasma nicotine levels were determined. Results: When rats were given a choice of nicotine or water, nicotine intake was similar between female and male rats. Menthol addition to nicotine solution significantly increased nicotine intake and preference in male but not female rats without a considerable effect on total fluid intake and body weight change in either sex. The average nicotine intake in male rats was 0.5 +/- 0.05 and 1.4 +/- 0.12 mg/kg/day for nicotine and menthol-nicotine combination (p <.05), respectively. The average nicotine intake in female rats was 0.6 +/- 0.05 and 0.6 +/- 0.03 mg/kg/day for nicotine and mentholnicotine combination (p >.05), respectively. Plasma nicotine levels were not significantly different between the groups in either male (nicotine group: 20.8 +/- 4.9, mentholated nicotine group: 31.9 +/- 3.2 ng/mL) or female (nicotine group: 24.0 +/- 3.3, mentholated nicotine group: 17.8 +/- 2.9 ng/mL) rats (p >.05). Conclusions: Menthol increases oral nicotine consumption in male, but not female, rats. | en_US |
dc.description.sponsorship | Canada Research Chair in Pharmacogenomics | en_US |
dc.description.sponsorship | Training and Education Core of the National Institute on Drug Abuse of the National Institutes of Health (NIH) (P50DA036105) | en_US |
dc.description.sponsorship | Center for Tobacco Products of the US Food and Drug Administration | en_US |
dc.description.sponsorship | Canadian Institutes of Health Research (FDN-154294) | en_US |
dc.description.sponsorship | Rat für Forschung und Technologieentwicklung | en_US |
dc.identifier.citation | Bağdaş, D. vd. (2020). "Impact of menthol on oral nicotine consumption in female and male sprague dawley rats". Nicotine and Tobacco Research, 22(2), 196-203. | en_US |
dc.identifier.endpage | 203 | tr_TR |
dc.identifier.issn | 1462-2203 | |
dc.identifier.issn | 1469-994X | |
dc.identifier.issue | 2 | tr_TR |
dc.identifier.pubmed | 30753589 | tr_TR |
dc.identifier.scopus | 2-s2.0-85079060389 | tr_TR |
dc.identifier.startpage | 196 | tr_TR |
dc.identifier.uri | https://doi.org/10.1093/ntr/ntz019 | |
dc.identifier.uri | https://academic.oup.com/ntr/article/22/2/196/5315480 | |
dc.identifier.uri | http://hdl.handle.net/11452/30709 | |
dc.identifier.volume | 22 | tr_TR |
dc.identifier.wos | 000546958300008 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Oxford University Press | en_US |
dc.relation.bap | KUAP-T 2016/15 | tr_TR |
dc.relation.collaboration | Yurt dışı | tr_TR |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.collaboration | Sanayi | tr_TR |
dc.relation.journal | Nicotine and Tobacco Research | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Substance abuse | en_US |
dc.subject | Public, environmental & occupational health | en_US |
dc.subject | Sex-dependent manner | en_US |
dc.subject | Smokeless tobacco | en_US |
dc.subject | Cigaratte-smoking | en_US |
dc.subject | Sensory neurons | en_US |
dc.subject | United-States | en_US |
dc.subject | Up-regulation | en_US |
dc.subject | Metabolism | en_US |
dc.subject | Products | en_US |
dc.subject | Receptor | en_US |
dc.subject | Smokers | en_US |
dc.subject.emtree | Menthol | en_US |
dc.subject.emtree | Nicotine | en_US |
dc.subject.emtree | Water | en_US |
dc.subject.emtree | Flavoring agent | en_US |
dc.subject.emtree | Menthol | en_US |
dc.subject.emtree | Nicotine | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Blood level | en_US |
dc.subject.emtree | Body weight change | en_US |
dc.subject.emtree | Decision making | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Fluid intake | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Sex difference | en_US |
dc.subject.emtree | Smokeless tobacco | en_US |
dc.subject.emtree | Substance use | en_US |
dc.subject.emtree | Animal | en_US |
dc.subject.emtree | Blood | en_US |
dc.subject.emtree | Drug effect | en_US |
dc.subject.emtree | Physiology | en_US |
dc.subject.emtree | Sexual characteristics | en_US |
dc.subject.emtree | Sprague Dawley rat | en_US |
dc.subject.emtree | Taste | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Choice behavior | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Flavoring agents | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Menthol | en_US |
dc.subject.mesh | Nicotine | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, sprague-dawley | en_US |
dc.subject.mesh | Sex characteristics | en_US |
dc.subject.mesh | Taste | en_US |
dc.subject.scopus | Menthol; Tobacco; Smoking | en_US |
dc.subject.wos | Substance abuse | en_US |
dc.subject.wos | Public, environmental & occupational health | en_US |
dc.title | Impact of menthol on oral nicotine consumption in female and male sprague dawley rats | en_US |
dc.type | Article | |
dc.wos.quartile | Q1 | en_US |