Impact of menthol on oral nicotine consumption in female and male sprague dawley rats

Simple item page
dc.contributor.authorBağdaş, Deniz
dc.contributor.authorGül, Zülfiye
dc.contributor.authorScott, Michael M.
dc.contributor.authorTyndale, Rachel F.
dc.contributor.authorDamaj, M. Imad
dc.contributor.buuauthorCam, Betül
dc.contributor.buuauthorBüyükuysal, Levent
dc.contributor.buuauthorGürün, Mine Sibel
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAH-1657-2021tr_TR
dc.contributor.researcheridCGO-3719-2022tr_TR
dc.contributor.researcheridDVX-8040-2022tr_TR
dc.contributor.scopusid56427863700tr_TR
dc.contributor.scopusid6602686612tr_TR
dc.contributor.scopusid55664349700tr_TR
dc.date.accessioned2023-01-30T08:46:11Z
dc.date.available2023-01-30T08:46:11Z
dc.date.issued2019-02-05
dc.description.abstractIntroduction: One of the preferable flavors in oral nicotine delivery systems is menthol which masks the harshness of tobacco. However, possible interactions between oral menthol and nicotine on intake and preference remain unclear. Therefore, we aimed to determine the impact of menthol on oral nicotine consumption. Methods: Adult Sprague Dawley female and male rats (n = 8 per group) were given a choice of water or drug solution by using two-bottle free choice paradigm for 2 weeks: vehicle (5% ethanol), nicotine (20 mg/L), menthol (1 g/L) and mentholated nicotine groups. At the end of the study, plasma nicotine levels were determined. Results: When rats were given a choice of nicotine or water, nicotine intake was similar between female and male rats. Menthol addition to nicotine solution significantly increased nicotine intake and preference in male but not female rats without a considerable effect on total fluid intake and body weight change in either sex. The average nicotine intake in male rats was 0.5 +/- 0.05 and 1.4 +/- 0.12 mg/kg/day for nicotine and menthol-nicotine combination (p <.05), respectively. The average nicotine intake in female rats was 0.6 +/- 0.05 and 0.6 +/- 0.03 mg/kg/day for nicotine and mentholnicotine combination (p >.05), respectively. Plasma nicotine levels were not significantly different between the groups in either male (nicotine group: 20.8 +/- 4.9, mentholated nicotine group: 31.9 +/- 3.2 ng/mL) or female (nicotine group: 24.0 +/- 3.3, mentholated nicotine group: 17.8 +/- 2.9 ng/mL) rats (p >.05). Conclusions: Menthol increases oral nicotine consumption in male, but not female, rats.en_US
dc.description.sponsorshipCanada Research Chair in Pharmacogenomicsen_US
dc.description.sponsorshipTraining and Education Core of the National Institute on Drug Abuse of the National Institutes of Health (NIH) (P50DA036105)en_US
dc.description.sponsorshipCenter for Tobacco Products of the US Food and Drug Administrationen_US
dc.description.sponsorshipCanadian Institutes of Health Research (FDN-154294)en_US
dc.description.sponsorshipRat für Forschung und Technologieentwicklungen_US
dc.identifier.citationBağdaş, D. vd. (2020). "Impact of menthol on oral nicotine consumption in female and male sprague dawley rats". Nicotine and Tobacco Research, 22(2), 196-203.en_US
dc.identifier.endpage203tr_TR
dc.identifier.issn1462-2203
dc.identifier.issn1469-994X
dc.identifier.issue2tr_TR
dc.identifier.pubmed30753589tr_TR
dc.identifier.scopus2-s2.0-85079060389tr_TR
dc.identifier.startpage196tr_TR
dc.identifier.urihttps://doi.org/10.1093/ntr/ntz019
dc.identifier.urihttps://academic.oup.com/ntr/article/22/2/196/5315480
dc.identifier.urihttp://hdl.handle.net/11452/30709
dc.identifier.volume22tr_TR
dc.identifier.wos000546958300008tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.bapKUAP-T 2016/15tr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalNicotine and Tobacco Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSubstance abuseen_US
dc.subjectPublic, environmental & occupational healthen_US
dc.subjectSex-dependent manneren_US
dc.subjectSmokeless tobaccoen_US
dc.subjectCigaratte-smokingen_US
dc.subjectSensory neuronsen_US
dc.subjectUnited-Statesen_US
dc.subjectUp-regulationen_US
dc.subjectMetabolismen_US
dc.subjectProductsen_US
dc.subjectReceptoren_US
dc.subjectSmokersen_US
dc.subject.emtreeMentholen_US
dc.subject.emtreeNicotineen_US
dc.subject.emtreeWateren_US
dc.subject.emtreeFlavoring agenten_US
dc.subject.emtreeMentholen_US
dc.subject.emtreeNicotineen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood levelen_US
dc.subject.emtreeBody weight changeen_US
dc.subject.emtreeDecision makingen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFluid intakeen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSex differenceen_US
dc.subject.emtreeSmokeless tobaccoen_US
dc.subject.emtreeSubstance useen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeBlooden_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreePhysiologyen_US
dc.subject.emtreeSexual characteristicsen_US
dc.subject.emtreeSprague Dawley raten_US
dc.subject.emtreeTasteen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChoice behavioren_US
dc.subject.meshFemaleen_US
dc.subject.meshFlavoring agentsen_US
dc.subject.meshMaleen_US
dc.subject.meshMentholen_US
dc.subject.meshNicotineen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshSex characteristicsen_US
dc.subject.meshTasteen_US
dc.subject.scopusMenthol; Tobacco; Smokingen_US
dc.subject.wosSubstance abuseen_US
dc.subject.wosPublic, environmental & occupational healthen_US
dc.titleImpact of menthol on oral nicotine consumption in female and male sprague dawley ratsen_US
dc.typeArticle
dc.wos.quartileQ1en_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Gürün_vd_2020.pdf
Size:
831.55 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Web of Science
PubMed
Scopus