Management of patients with coexisting obstructive sleep apnea and laryngopharyngeal reflux disease

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dc.contributor.authorErişen, Levent
dc.contributor.buuauthorEryılmaz, Aylin
dc.contributor.buuauthorDemir, Uygar Levent
dc.contributor.buuauthorKasapoǧlu, Fikret
dc.contributor.buuauthorÖzmen, Ömer Afşin
dc.contributor.buuauthorUrsavaş, Ahmet
dc.contributor.buuauthorKıyıcı, Murat
dc.contributor.buuauthorHızalan, İbrahim
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-9698-0546tr_TR
dc.contributor.orcid0000-0002-3208-6211tr_TR
dc.contributor.researcheridA-1452-2019tr_TR
dc.contributor.researcheridAAI-4213-2021tr_TR
dc.contributor.researcheridAAI-3877-2021tr_TR
dc.contributor.researcheridAAI-3169-2021tr_TR
dc.contributor.scopusid56305841300tr_TR
dc.contributor.scopusid56868421800tr_TR
dc.contributor.scopusid56254721200tr_TR
dc.contributor.scopusid55407733900tr_TR
dc.contributor.scopusid8329319900tr_TR
dc.contributor.scopusid6507627491tr_TR
dc.contributor.scopusid6506478628tr_TR
dc.date.accessioned2022-04-12T05:30:09Z
dc.date.available2022-04-12T05:30:09Z
dc.date.issued2012-12
dc.description.abstractObstructive sleep apnea syndrome (OSAS) and Laryngopharyngeal reflux disease (LPR) are both common health problems causing severe morbidity. Since they have similar risk factors, the prevalence of LPR among patients with OSAS is higher compared with general population. However, there exist only a few studies showing the potential causal relation between LPR and OSAS. The aim of this study was to evaluate the coexistence between OSAS and LPR and to determine whether the therapy of OSAS alters LPR parameters and vice versa. In this study, 44 patients underwent double probed 24 h pH monitoring simultaneously with polysomnography due to the complaints of obstructive sleep apnea and reflux. Twenty of those 44 patients were diagnosed with both OSAS and LPR. Among those patients, 10 patients with mild to moderate OSAS were given only LPR treatment for 3 months. The remaining 10 patients who had severe OSAS underwent CPAP treatment for 3 months. After the end of treatment, all patients were reevaluated with double probed 24 h pH monitoring simultaneously with PSG. Moreover, the patients were evaluated subjectively by Epworth Sleepiness Scale (ESS), snoring Visual Analogue Scale (VAS), Reflux Symptom Index (RSI), and Reflux Finding Score (RFS). The results of this study revealed that OSAS and LPR coexist frequently. LPR treatment did not improve the polysomnographic parameters, but significantly reduced ESS and snoring VAS (p = 0.02 and p = 0.007, respectively). Although the CPAP treatment significantly improved subjective parameters of reflux, such as RSI and RFS (p = 0.016 for both), there was no significant improvement in objective parameters of 24-h pH monitoring. We concluded that since there is a high frequency of coexistence between LPR and OSAS, all patients with OSAS should also be queried for LPR symptoms. In addition, more in-depth and comprehensive research is required to elucidate the association between OSAS and LPR.en_US
dc.identifier.citationEryılmaz, A. vd. (2012). "Management of patients with coexisting obstructive sleep apnea and laryngopharyngeal reflux disease". European Archives of Oto-Rhino-Laryngology, 269(12), 2575-2580.en_US
dc.identifier.endpage2580tr_TR
dc.identifier.issn0937-4477
dc.identifier.issue12tr_TR
dc.identifier.pubmed22707319tr_TR
dc.identifier.scopus2-s2.0-84871295293tr_TR
dc.identifier.startpage2575tr_TR
dc.identifier.urihttps://doi.org/10.1007/s00405-012-2062-z
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs00405-012-2062-z
dc.identifier.urihttp://hdl.handle.net/11452/25711
dc.identifier.volume269tr_TR
dc.identifier.wos000310810400019tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalEuropean Archives of Oto-Rhino-Laryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOtorhinolaryngologyen_US
dc.subjectObstructive sleep apnea syndromeen_US
dc.subjectLaryngopharyngeal refluxen_US
dc.subjectContinuous positive airway pressureen_US
dc.subjectPolysomnographyen_US
dc.subjectDouble probed 24 h pH monitoringen_US
dc.subjectPositive airway pressureen_US
dc.subjectSymptomatic gastroesophageal-refluxen_US
dc.subjectProximal probeen_US
dc.subjectPantoprazoleen_US
dc.subjectReliabilityen_US
dc.subjectValidityen_US
dc.subjectAdultsen_US
dc.subjectAciden_US
dc.subjectGerden_US
dc.subjectMenen_US
dc.subject.emtreeApnea hypopnea indexen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeElectroencephalographyen_US
dc.subject.emtreeEsophageal pH monitoringen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLaryngopharyngeal refluxen_US
dc.subject.emtreePolysomnographyen_US
dc.subject.emtreePositive end expiratory pressureen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeSleep disordered breathingen_US
dc.subject.emtreeVisual analog scaleen_US
dc.subject.meshAdulten_US
dc.subject.meshAnti-ulcer agentsen_US
dc.subject.meshContinuous positive airway pressureen_US
dc.subject.meshEsophageal pH monitoringen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLaryngopharyngeal refluxen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshPolysomnographyen_US
dc.subject.meshProton pump inhibitorsen_US
dc.subject.meshSeverity of illness indexen_US
dc.subject.meshSleep apnea, obstructiveen_US
dc.subject.scopusGastroesophageal Reflux; Hiatus Hernia; Esophagitisen_US
dc.subject.wosOtorhinolaryngologyen_US
dc.titleManagement of patients with coexisting obstructive sleep apnea and laryngopharyngeal reflux diseaseen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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