Promising anti-growth effects of palladium(II) saccharinate complex of terpyridine by inducing apoptosis on transformed fibroblasts in vitro

Simple item page
dc.contributor.authorKutlu, Hatice Mehtap
dc.contributor.buuauthorCoşkun, Melis Debreli
dc.contributor.buuauthorArı, Ferda
dc.contributor.buuauthorOral, Arzu Yılmaztepe
dc.contributor.buuauthorSarımahmut, Mehmet
dc.contributor.buuauthorYılmaz, Veysel Turan
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-2849-3332tr_TR
dc.contributor.orcid0000-0002-6729-7908tr_TR
dc.contributor.orcid0000-0003-0463-6818tr_TR
dc.contributor.orcid0000-0003-2647-5875tr_TR
dc.contributor.researcheridK-5792-2018tr_TR
dc.contributor.researcheridAAF-3992-2020tr_TR
dc.contributor.researcheridAAG-8288-2021tr_TR
dc.contributor.researcheridA-5841-2017tr_TR
dc.contributor.researcheridAAG-7012-2021tr_TR
dc.contributor.researcheridL-7238-2018tr_TR
dc.contributor.scopusid57204274361tr_TR
dc.contributor.scopusid24376085300tr_TR
dc.contributor.scopusid23091316500tr_TR
dc.contributor.scopusid44661687400tr_TR
dc.contributor.scopusid7006269202tr_TR
dc.contributor.scopusid6602927353tr_TR
dc.date.accessioned2022-11-11T08:14:14Z
dc.date.available2022-11-11T08:14:14Z
dc.date.issued2013-08
dc.description.abstractFibrosarcoma is one of the fatal cancer types and there is still not satisfactory success in its treatment despite new drugs. Therefore, the search for a new compound has been going on. It is currently known that some palladium-based anti-cancer compounds seem to have powerful apoptosis-inducing effects in cancer cells. For this purpose, a palladium(II)-saccharinate complex containing terpyridine which was synthesized by our research group was investigated in terms of its anti-tumor effects against mouse embryonic fibroblast NIH/3T3 (normal cell line) and rat embryonic fibroblast 5RP7 (H-ras transformed cell line) in vitro. The MTT and ATP viability assays were used to determine anti-growth/cytotoxic effects. Cytotoxic activity was confirmed by real time cytotoxicity analysis system. Flow cytometry analysis was further used to determine the mode of cell death (apoptosis/necrosis). Apoptosis was confirmed by triple-staining the cells with Hoechst 33342/PI/Calcein-AM triple and evaluated with fluorescence microscopy. It was found that the compound showed significant anti-growth activity by inducing apoptosis in a dose dependent manner. In conclusion, taking into account the cytotoxic activity of the compound at even relatively lower doses, in vivo experiments to elucidate its potential use for the treatment of fibrosarcoma are warranted.en_US
dc.description.sponsorshipAnadolu Üniversitesi (1110F164)tr_TR
dc.identifier.citationCoşkun, M. D. vd. (2013). "Promising anti-growth effects of palladium(II) saccharinate complex of terpyridine by inducing apoptosis on transformed fibroblasts in vitro". Bioorganic and Medicinal Chemistry, 21(15), 4698-4705.en_US
dc.identifier.endpage4705tr_TR
dc.identifier.issn0968-0896
dc.identifier.issn1464-3391
dc.identifier.issue15tr_TR
dc.identifier.pubmed23751940tr_TR
dc.identifier.scopus2-s2.0-84879686564tr_TR
dc.identifier.startpage4698tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2013.05.023
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0968089613004586
dc.identifier.urihttp://hdl.handle.net/11452/29454
dc.identifier.volume21tr_TR
dc.identifier.wos000321496300028tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Scienceen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalBioorganic and Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectChemistryen_US
dc.subjectPalladium(II) complexesen_US
dc.subjectFibrosarcomaen_US
dc.subjectCytotoxicityen_US
dc.subjectApoptosisen_US
dc.subjectPlatinum(II) complexesen_US
dc.subjectBiological evaluationen_US
dc.subjectCytotoxic activityen_US
dc.subjectBeta-lactoglobulinen_US
dc.subjectAntitumoren_US
dc.subjectAnticanceren_US
dc.subjectIfosfamideen_US
dc.subjectDesignen_US
dc.subjectPd(II)en_US
dc.subjectPt(II)en_US
dc.subjectRattusen_US
dc.subject.emtreeCalceinen_US
dc.subject.emtreeHoe 33342en_US
dc.subject.emtreePalladium complexen_US
dc.subject.emtreePropidium iodideen_US
dc.subject.emtreePyridine derivativeen_US
dc.subject.emtreeAnimal cellen_US
dc.subject.emtreeAntineoplastic activityen_US
dc.subject.emtreeApoptosisen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCancer cell cultureen_US
dc.subject.emtreeCell assayen_US
dc.subject.emtreeCell deathen_US
dc.subject.emtreeCell transformationen_US
dc.subject.emtreeConcentration responseen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCytochemistryen_US
dc.subject.emtreeDrug cytotoxicityen_US
dc.subject.emtreeDrug structureen_US
dc.subject.emtreeDrug synthesisen_US
dc.subject.emtreeEmbryoen_US
dc.subject.emtreeFibroblasten_US
dc.subject.emtreeFibrosarcomaen_US
dc.subject.emtreeFlow cytometryen_US
dc.subject.emtreeFluorescence microscopyen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeIn vitro studyen_US
dc.subject.emtreeMouseen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeRaten_US
dc.subject.scopusComplex; Palladium; 2-Phenylpyridineen_US
dc.subject.wosBiochemistry & molecular biologyen_US
dc.subject.wosChemistry, medicinalen_US
dc.subject.wosChemistry, organicen_US
dc.titlePromising anti-growth effects of palladium(II) saccharinate complex of terpyridine by inducing apoptosis on transformed fibroblasts in vitroen_US
dc.typeArticle
dc.wos.quartileQ2en_US

Files

License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Web of Science
PubMed
Scopus