Recrudescence of spermatogenesis in the dog following downregulation using a slow release GnRH agonist implant

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dc.contributor.authorGoericke-Pesch, Sandra
dc.contributor.authorSpang, A.
dc.contributor.authorSchulz, M.
dc.contributor.authorBergmann, M.
dc.contributor.authorLudwig, Carmen
dc.contributor.authorHoffmann, B.
dc.contributor.buuauthorÖzalp, Gözde Rabia
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-4694-6937tr_TR
dc.contributor.researcheridAAE-3607-2019tr_TR
dc.contributor.scopusid23985710500tr_TR
dc.date.accessioned2021-11-29T11:09:51Z
dc.date.available2021-11-29T11:09:51Z
dc.date.issued2009-07
dc.descriptionBu çalışma, 9-11 Temmuz 2008 tarihlerinde Viyana Üniversitesi[Avusturya]'da düzenlenen 6. International Symposium on Canine and Feline Reproduction'da bildiri olarak sunulmuştru.tr_TR
dc.description.abstractThe present study examined the degree to which downregulation with a GnRH agonist impaired spermatogenesis and the time course of morphological and hormonal changes that occurred during recrudescence of spermatogenesis. Using a control group (group 1, n = 5) of dogs, the effect of a removable slow release GnRH-agonist implant was investigated in beagle dogs (group 2, n = 30). The implant was removed after 5 months (week 0) and three to four dogs were castrated at weeks 0, 3, 6, 9, 12, 15, 18, 21 and 24. The degree of downregulation and recrudescence of spermatogenesis was assessed by evaluation of 200 tubular cross-sections, resulting in an assigning of dogs of group 2 to testis developmental groups (DG) according to the most developed germ cell observed: DG A, spermatocytes; DG B, round spermatids; DG C, elongating spermatids and DG D, elongated spermatids. Downregulation led to an arrest of spermatogenesis at the level of spermatogonia/primary spermatocytes. The time course of recrudescence showed high individual variations and the number of dogs falling into DG A, B, C and D was 4, 3, 6 and 17 respectively. Spermatogenesis in group 2, DG D was not different from group 1 (control). In DG A, mean area of Leydig-cell nuclei was lower (p < 0.001) than in the other DG and group 1 and resembled that of juvenile dogs (group 3, n = 3); nuclei of Sertoli cells had changed from more flat/polygonal (group 1, group 2, DG C and D) to round/ovoid and had moved to a more luminal position. As indicated by basal testosterone (T), luteinizing hormone (LH) and follicle stimulating hormone (FSH) concentrations at implant removal, full downregulation had been obtained. Testosterone, LH and FSH concentrations [<(X)over bar>(g) (DF), ng/ml] increased (p < 0.05) from implant removal to DG B [T: 0.1 (1.24) vs 2.12 (2.31); LH: 0.2 (2.15) vs 1.11 (1.7); FSH: 0.37 (3.50) vs 6.37 (1.68)] and were more or less constant thereafter indicating that onset of spermatogenesis was related to an increase of plasma T occurring in a very narrow time window. Following GnRH implantation, the size of the testes and the prostate decreased by approximately 55% (p < 0.001), they increased to sizes similar to pre-treatment values following implant removal.tr_TR
dc.identifier.citationGoericke-Pesch, S. vd. (2009). "Recrudescence of spermatogenesis in the dog following downregulation using a slow release GnRH agonist implant". Reproduction in Domestic Animals, 44, Supplement 2, 302-308.tr_TR
dc.identifier.endpage308tr_TR
dc.identifier.issn0936-6768
dc.identifier.issueSupplement 2tr_TR
dc.identifier.pubmed19754591tr_TR
dc.identifier.scopus2-s2.0-67651214088tr_TR
dc.identifier.startpage302tr_TR
dc.identifier.urihttps://doi.org/10.1111/j.1439-0531.2009.01378.x
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/j.1439-0531.2009.01378.x
dc.identifier.urihttp://hdl.handle.net/11452/22854
dc.identifier.volume44tr_TR
dc.identifier.wos000267756400064tr_TR
dc.indexed.pubmedPubmedtr_TR
dc.indexed.scopusScopustr_TR
dc.indexed.wosSCIEtr_TR
dc.language.isoentr_TR
dc.publisherWileytr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalReproduction in Domestic Animalstr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccesstr_TR
dc.subjectTesticular functiontr_TR
dc.subjectSemen qualitytr_TR
dc.subjectHormonetr_TR
dc.subjectTestistr_TR
dc.subjectTestosteronetr_TR
dc.subjectSeasonalitytr_TR
dc.subjectPhotoperiodtr_TR
dc.subjectPlasmatr_TR
dc.subjectCycletr_TR
dc.subjectAgriculturetr_TR
dc.subjectReproductive biologytr_TR
dc.subjectVeterinary sciencestr_TR
dc.subjectCanis familiaristr_TR
dc.subject.emtreeAntispermatogenic agenttr_TR
dc.subject.emtreeAzaglycylnafarelintr_TR
dc.subject.emtreeDrug derivativetr_TR
dc.subject.emtreeGonadorelintr_TR
dc.subject.emtreeNafarelintr_TR
dc.subject.emtreeAnimaltr_TR
dc.subject.emtreeAnimal diseasetr_TR
dc.subject.emtreeClinical trialtr_TR
dc.subject.emtreeConference papertr_TR
dc.subject.emtreeControlled clinical trialtr_TR
dc.subject.emtreeControlled studytr_TR
dc.subject.emtreeCytologytr_TR
dc.subject.emtreeDelayed release formulationtr_TR
dc.subject.emtreeDogtr_TR
dc.subject.emtreeDrug administrationtr_TR
dc.subject.emtreeDrug effecttr_TR
dc.subject.emtreeDrug implanttr_TR
dc.subject.emtreeDrug potentiationtr_TR
dc.subject.emtreeMaletr_TR
dc.subject.emtreeRandomized controlled trialtr_TR
dc.subject.emtreeSexual maturationtr_TR
dc.subject.emtreeSpermatogenesistr_TR
dc.subject.emtreeSpermatozoon counttr_TR
dc.subject.emtreeTestistr_TR
dc.subject.meshAnimalstr_TR
dc.subject.meshAntispermatogenic agentstr_TR
dc.subject.meshDelayed-action preparationstr_TR
dc.subject.meshDogstr_TR
dc.subject.meshDrug administration scheduletr_TR
dc.subject.meshDrug implantstr_TR
dc.subject.meshGonadotropin-releasing hormonetr_TR
dc.subject.meshMaletr_TR
dc.subject.meshNafarelintr_TR
dc.subject.meshSexual maturationtr_TR
dc.subject.meshSperm counttr_TR
dc.subject.meshSpermatogenesistr_TR
dc.subject.meshTestistr_TR
dc.subject.scopusPyometra; Bitches; Deslorelintr_TR
dc.subject.wosAgriculture, dairy & animal sciencetr_TR
dc.subject.wosReproductive biologytr_TR
dc.subject.wosVeterinary sciencestr_TR
dc.titleRecrudescence of spermatogenesis in the dog following downregulation using a slow release GnRH agonist implanttr_TR
dc.typeProceedings Paper
dc.typeArticle
dc.wos.quartileQ1tr_TR
dc.wos.quartileQ3 (Reproductive biology)tr_TR

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