Mixed ligand complexes of Co(II), Ni(II) and Cu(II) with quercetin and diimine ligands: Synthesis, characterization, anti-cancer and anti-oxidant activity
dc.contributor.author | Ulukaya, Engin | |
dc.contributor.buuauthor | Gençkal, Hasene | |
dc.contributor.buuauthor | Erkısa, Merve | |
dc.contributor.buuauthor | Pınar, Alper | |
dc.contributor.buuauthor | Şahin, Saliha | |
dc.contributor.buuauthor | Arı, Ferda | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü. | tr_TR |
dc.contributor.department | Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü. | tr_TR |
dc.contributor.orcid | 0000-0002-6729-7908 | tr_TR |
dc.contributor.orcid | 0000-0002-3127-742X | tr_TR |
dc.contributor.orcid | 0000-0002-0026-7755 | tr_TR |
dc.contributor.researcherid | AAH-2892-2021 | tr_TR |
dc.contributor.scopusid | 57212275330 | tr_TR |
dc.contributor.scopusid | 57126208900 | tr_TR |
dc.contributor.scopusid | 15027401600 | tr_TR |
dc.contributor.scopusid | 24376085300 | tr_TR |
dc.date.accessioned | 2023-01-30T12:48:49Z | |
dc.date.available | 2023-01-30T12:48:49Z | |
dc.date.issued | 2019-12-02 | |
dc.description.abstract | In this work, mixed ligand complexes of Co(II) Ni(II) and Cu(II) were synthesized using quercetin and diimine (1,10-phenanthroline or 2,2 '-bipyiridine) ligands. The obtained Ni(II) and Co(II) complexes are new and the Cu(II) complexes are synthesized by different method from the literature. The characterization of complexes was performed by elemental analysis, thermogravimetric analysis, ESI-MS, UV-visible and infrared spectral analyses, magnetic susceptibility and molar conductivity measurements. It was found that quercetin, diimine and metal(II) ion form 1:1:1 complexes. Resulting data supported octahedral geometry for Ni(II) and Co(II) complexes and square pyramidal geometry for Cu(II) complexes. The proposed compositions are [Co(queH-1)Cl(phen)(H2O)]center dot 2H(2)O (1, queH = quercetin, phen = 1,10-phenanthroline), [Ni(queH-1)Cl(phen)(H2O)]center dot 2H(2)O (2), [Cu(queH-1)Cl(phen)]center dot 2.5H(2)O (3) and [Cu(queH-1)Cl(bpy)]center dot 2H(2)O (4, bpy = 2,2 '-bipyiridine). Antioxidant capacity and total phenolic content of complexes measured by Folin-Ciocalteu and ABTS methods. Anti-cancer effect of these compounds were tested against different cancer cells (A549, PC-3, HeLa and MCF-7). Apoptosis identified by the fluorescence imaging, caspase cleaved cytokeratin-18 and flow cytometry analysis (annexin V, caspase 3/7, mitochondria membrane potential and oxidative stress). As a result, Cu(II) complexes are more effective than the other compounds and Complex 3 is a promising anti-cancer compound against breast cancer MCF-7 and MDA-MB-231 cells (IC50 values are 2.4 and 5.4 mu M for 48 h, respectively). Flow cytometry analysis exhibited that Complex 3 caused apoptosis in MCF-7 cells. These results support that Complex 3 has anticancer activity and can be a potential anticancer agent especially in breast cancer. | en_US |
dc.identifier.citation | Gençkal, H. M. vd. (2020). "Mixed ligand complexes of Co(II), Ni(II) and Cu(II) with quercetin and diimine ligands: Synthesis, characterization, anti-cancer and anti-oxidant activity". Journal of Biological Inorganic Chemistry, 25(1), 161-177. | en_US |
dc.identifier.endpage | 177 | tr_TR |
dc.identifier.issn | 0949-8257 | |
dc.identifier.issn | 1432-1327 | |
dc.identifier.issue | 1 | tr_TR |
dc.identifier.pubmed | 31832781 | tr_TR |
dc.identifier.scopus | 2-s2.0-85076348979 | tr_TR |
dc.identifier.startpage | 161 | tr_TR |
dc.identifier.uri | https://doi.org/10.1007/s00775-019-01749-z | |
dc.identifier.uri | https://link.springer.com/article/10.1007/s00775-019-01749-z | |
dc.identifier.uri | http://hdl.handle.net/11452/30719 | |
dc.identifier.volume | 25 | tr_TR |
dc.identifier.wos | 000519936700015 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.relation.bap | OUAP (F)–2014/27 | tr_TR |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.journal | Journal of Biological Inorganic Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Flavonoid complexes | en_US |
dc.subject | Quercetin | en_US |
dc.subject | 1 | tr_TR |
dc.subject | 10-Phenanthroline | en_US |
dc.subject | 2 | tr_TR |
dc.subject | 2 '-bipyridine | en_US |
dc.subject | Cytotoxicity | en_US |
dc.subject | Anti-cancer activity | en_US |
dc.subject | Antioxidant activity | en_US |
dc.subject | Mitochondria-mediated apoppsis | en_US |
dc.subject | Cell-cycle arrest | en_US |
dc.subject | Antitumor activities | en_US |
dc.subject | Copper(II) complexes | en_US |
dc.subject | Metal-complexes | en_US |
dc.subject | II complexes | en_US |
dc.subject | DNA-binding | en_US |
dc.subject | Flavonoids | en_US |
dc.subject | Activation | en_US |
dc.subject | Derivatives | en_US |
dc.subject | Biochemistry & molecular biology | en_US |
dc.subject | Chemistry | en_US |
dc.subject.emtree | Antineoplastic agent | en_US |
dc.subject.emtree | Antioxidant | en_US |
dc.subject.emtree | Caspase | en_US |
dc.subject.emtree | Caspase 3 | en_US |
dc.subject.emtree | Caspase 7 | en_US |
dc.subject.emtree | Cobalt complex | en_US |
dc.subject.emtree | Copper complex | en_US |
dc.subject.emtree | Cytokeratin 18 | en_US |
dc.subject.emtree | Diimine | en_US |
dc.subject.emtree | Lipocortin 5 | en_US |
dc.subject.emtree | Phenol derivative | en_US |
dc.subject.emtree | Quercetin | en_US |
dc.subject.emtree | Unclassified drug | en_US |
dc.subject.emtree | Antineoplastic agent | en_US |
dc.subject.emtree | Antioxidant | en_US |
dc.subject.emtree | Cobalt | en_US |
dc.subject.emtree | Coordination compound | en_US |
dc.subject.emtree | Copper | en_US |
dc.subject.emtree | Imine | en_US |
dc.subject.emtree | Ligand | en_US |
dc.subject.emtree | Nickel | en_US |
dc.subject.emtree | Quercetin | en_US |
dc.subject.emtree | A-549 cell line | en_US |
dc.subject.emtree | ABTS radical scavenging assay | en_US |
dc.subject.emtree | Antineoplastic activity | en_US |
dc.subject.emtree | Antioxidant activity | en_US |
dc.subject.emtree | Apoptosis | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Cell proliferation | en_US |
dc.subject.emtree | Chemical composition | en_US |
dc.subject.emtree | Complex formation | en_US |
dc.subject.emtree | Conductance | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Drug structure | en_US |
dc.subject.emtree | Drug synthesis | en_US |
dc.subject.emtree | Electrospray mass spectrometry | en_US |
dc.subject.emtree | Elemental analysis | en_US |
dc.subject.emtree | Flow cytometry | en_US |
dc.subject.emtree | Fluorescence | en_US |
dc.subject.emtree | Folin Ciocalteu method | en_US |
dc.subject.emtree | Geometry | en_US |
dc.subject.emtree | HeLa cell line | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Human cell | en_US |
dc.subject.emtree | IC50 | en_US |
dc.subject.emtree | Infrared spectroscopy | en_US |
dc.subject.emtree | Ligand binding | en_US |
dc.subject.emtree | Magnetism | en_US |
dc.subject.emtree | MCF-7 cell line | en_US |
dc.subject.emtree | MDA-MB-231 cell line | en_US |
dc.subject.emtree | Mitochondrial membrane potential | en_US |
dc.subject.emtree | Oxidative stress | en_US |
dc.subject.emtree | PC-3 [Human pancreatic carcinoma] cell line | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Protein cleavage | en_US |
dc.subject.emtree | Thermal analysis | en_US |
dc.subject.emtree | Thermogravimetry | en_US |
dc.subject.emtree | Ultraviolet C radiation | en_US |
dc.subject.emtree | Chemistry | en_US |
dc.subject.emtree | Procedures | en_US |
dc.subject.emtree | Spectroscopy | en_US |
dc.subject.emtree | Tumor cell line | en_US |
dc.subject.mesh | Antineoplastic agents | en_US |
dc.subject.mesh | Antioxidants | en_US |
dc.subject.mesh | Cell line | en_US |
dc.subject.mesh | Tumor | en_US |
dc.subject.mesh | Cobalt | en_US |
dc.subject.mesh | Coordination complexes | en_US |
dc.subject.mesh | Copper | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Imines | en_US |
dc.subject.mesh | Ligands | en_US |
dc.subject.mesh | Nickel | en_US |
dc.subject.mesh | Quercetin | en_US |
dc.subject.mesh | Spectrum analysis | en_US |
dc.subject.scopus | Taxifolin; Morin; Complex | en_US |
dc.subject.wos | Biochemistry & molecular biology | en_US |
dc.subject.wos | Chemistry, inorganic & nuclear | en_US |
dc.title | Mixed ligand complexes of Co(II), Ni(II) and Cu(II) with quercetin and diimine ligands: Synthesis, characterization, anti-cancer and anti-oxidant activity | en_US |
dc.type | Article | |
dc.wos.quartile | Q2 (Chemistry, inorganic & nuclear) | en_US |
dc.wos.quartile | Q3 | en_US |
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