A reference interval study for common biochemical analytes in Eastern Turkey: A comparison of a reference population with laboratory data mining

dc.contributor.authorBakan, Ebubekir
dc.contributor.authorPolat, Harun
dc.contributor.authorÖztürk, Nurinnisa
dc.contributor.authorBaygutalp, Nurcan Kılıç
dc.contributor.authorUmudum, Fatma Zuhal
dc.contributor.authorBakan, Nuri
dc.contributor.buuauthorÖzarda, Yeşim
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.tr_TR
dc.contributor.researcheridAAL-8873-2021tr_TR
dc.contributor.scopusid35741320500tr_TR
dc.date.accessioned2022-11-25T08:22:43Z
dc.date.available2022-11-25T08:22:43Z
dc.date.issued2016-03-06
dc.description.abstractIntroduction: The aim of this study was to define the reference intervals (RIs) in a Turkish population living in Northeast Turkey (Erzurum) for 34 analytes using direct and indirect methods. In the present study, the regional RIs obtained were compared with other RI studies, primarily the nationwide study performed in Turkey. Materials and methods: For the direct method, 435 blood samples were collected from a healthy group of females (N = 218) and males (N = 217) aged between 18 and 65 years. The sera were analysed in Ataturk University hospital laboratory using Roche reagents and analysers for 34 analytes. The data from 1,366,948 records were used to calculate the indirect RIs using a modified Bhattacharya method. Results: Significant gender-related differences were observed for 17 analytes. There were also some apparent differences between RIs derived from indirect and direct methods particularly in some analytes (e.g. gamma-glutamyltransferase, creatine kinase, LDL-cholesterol and iron). The RIs derived with the direct method for some, but not all, of the analytes were generally comparable with the RIs reported in the nationwide study and other previous studies in Turkey. There were large differences between RIs derived by the direct method and the expected values shown in the kit insert (e.g. aspartate aminotransferase, total-cholesterol, HDL-cholesterol, and vitamin B12). Conclusions: These data provide region-specific RIs for 34 analytes determined by the direct and indirect methods. The observed differences in RIs between previous studies could be related to nutritional status and environmental factors.en_US
dc.identifier.citationBakan, E. vd. (2016). "A reference interval study for common biochemical analytes in Eastern Turkey: a comparison of a reference population with laboratory data mining". Biochemia Medica, 26(2), 210-223.en_US
dc.identifier.endpage223tr_TR
dc.identifier.issn1330-0962
dc.identifier.issn1846-7482
dc.identifier.issue2tr_TR
dc.identifier.pubmed27346966tr_TR
dc.identifier.scopus2-s2.0-84973495161tr_TR
dc.identifier.startpage210tr_TR
dc.identifier.urihttps://doi.org/10.11613/BM.2016.023
dc.identifier.urihttps://www.biochemia-medica.com/en/journal/26/2/10.11613/BM.2016.023
dc.identifier.urihttp://hdl.handle.net/11452/29568
dc.identifier.volume26tr_TR
dc.identifier.wos000377907400010tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherCroatian Soc medical Biochemistry & Laboratory Medicineen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalBiochemia Medicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMedical laboratory technologyen_US
dc.subjectReference intervalsen_US
dc.subjectDirect methoden_US
dc.subjectIndirect methoden_US
dc.subjectBhattacharya methoden_US
dc.subjectRegional differencesen_US
dc.subjectReference valuesen_US
dc.subjectWorldwide multicenteren_US
dc.subject.emtreeAlanine aminotransferaseen_US
dc.subject.emtreeAlbuminen_US
dc.subject.emtreeAlkaline phosphataseen_US
dc.subject.emtreeAmylaseen_US
dc.subject.emtreeAspartate aminotransferaseen_US
dc.subject.emtreeBilirubinen_US
dc.subject.emtreeCalciumen_US
dc.subject.emtreeChlorideen_US
dc.subject.emtreeCreatine kinaseen_US
dc.subject.emtreeCreatinineen_US
dc.subject.emtreeCyanocobalaminen_US
dc.subject.emtreeFolic aciden_US
dc.subject.emtreeGamma glutamyltransferaseen_US
dc.subject.emtreeGlucoseen_US
dc.subject.emtreeHigh density lipoprotein cholesterolen_US
dc.subject.emtreeIronen_US
dc.subject.emtreeLactate dehydrogenaseen_US
dc.subject.emtreeLiothyronineen_US
dc.subject.emtreeLow density lipoprotein cholesterolen_US
dc.subject.emtreeMagnesiumen_US
dc.subject.emtreePhosphateen_US
dc.subject.emtreePotassiumen_US
dc.subject.emtreeProteinen_US
dc.subject.emtreeSodiumen_US
dc.subject.emtreeThyrotropinen_US
dc.subject.emtreeThyroxineen_US
dc.subject.emtreeTriacylglycerolen_US
dc.subject.emtreeUnindexed drugen_US
dc.subject.emtreeUreaen_US
dc.subject.emtreeUric aciden_US
dc.subject.emtreeAspartate aminotransferaseen_US
dc.subject.emtreeHigh density lipoprotein cholesterolen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeChemiluminescence immunoassayen_US
dc.subject.emtreeCholesterol blood levelen_US
dc.subject.emtreeColorimetryen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeEnvironmental factoren_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMass spectrometryen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeNutritional statusen_US
dc.subject.emtreeQuestionnaireen_US
dc.subject.emtreeReference valueen_US
dc.subject.emtreeSerologyen_US
dc.subject.emtreeTurkey (republic)en_US
dc.subject.emtreeUltraviolet spectrophotometryen_US
dc.subject.emtreeVery elderlyen_US
dc.subject.emtreeYoung adulten_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeBlooden_US
dc.subject.emtreeBlood analysisen_US
dc.subject.emtreeData miningen_US
dc.subject.emtreeHospital laboratoryen_US
dc.subject.emtreeProceduresen_US
dc.subject.emtreeReference valueen_US
dc.subject.emtreeStandardsen_US
dc.subject.emtreeTurkeyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAspartate aminotransferasesen_US
dc.subject.meshBlood chemical analysisen_US
dc.subject.meshCholesterol, HDLen_US
dc.subject.meshData miningen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLaboratories, hospitalen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshReference valuesen_US
dc.subject.meshTurkeyen_US
dc.subject.scopusClinical Chemistry; Thyrotropin; Chemical Speciesen_US
dc.subject.wosMedical laboratory technologyen_US
dc.titleA reference interval study for common biochemical analytes in Eastern Turkey: A comparison of a reference population with laboratory data miningen_US
dc.typeArticle
dc.wos.quartileQ1en_US

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