Advances and recent developments in asthma in 2020

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dc.contributor.buuauthorCevhertaş, Laçin
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-2287-3569tr_TR
dc.contributor.scopusid57216918051tr_TR
dc.date.accessioned2022-11-24T08:55:53Z
dc.date.available2022-11-24T08:55:53Z
dc.date.issued2020-09-30
dc.descriptionBu çalışmada 22 yazar bulunmaktadır. Bu yazarlardan sadece Bursa Uludağ Üniversitesi mensuplarının girişleri yapılmıştır.tr_TR
dc.description.abstractIn this review, we discuss recent publications on asthma and review the studies that have reported on the different aspects of the prevalence, risk factors and prevention, mechanisms, diagnosis, and treatment of asthma. Many risk and protective factors and molecular mechanisms are involved in the development of asthma. Emerging concepts and challenges in implementing the exposome paradigm and its application in allergic diseases and asthma are reviewed, including genetic and epigenetic factors, microbial dysbiosis, and environmental exposure, particularly to indoor and outdoor substances. The most relevant experimental studies further advancing the understanding of molecular and immune mechanisms with potential new targets for the development of therapeutics are discussed. A reliable diagnosis of asthma, disease endotyping, and monitoring its severity are of great importance in the management of asthma. Correct evaluation and management of asthma comorbidity/multimorbidity, including interaction with asthma phenotypes and its value for the precision medicine approach and validation of predictive biomarkers, are further detailed. Novel approaches and strategies in asthma treatment linked to mechanisms and endotypes of asthma, particularly biologicals, are critically appraised. Finally, due to the recent pandemics and its impact on patient management, we discuss the challenges, relationships, and molecular mechanisms between asthma, allergies, SARS-CoV-2, and COVID-19.en_US
dc.description.sponsorshipSanofi & Regeneronen_US
dc.description.sponsorshipGlaxoSmithKlineen_US
dc.description.sponsorshipEuropean Commissionen_US
dc.description.sponsorshipSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschungen_US
dc.description.sponsorshipChristine Kühne – Center for Allergy Research and Educationen_US
dc.identifier.citationCevhertaş, L. vd. (2020). "Advances and recent developments in asthma in 2020". Allergy: European Journal of Allergy and Clinical Immunology, 75(12), 3124-3146.en_US
dc.identifier.endpage3146tr_TR
dc.identifier.issn0105-4538
dc.identifier.issue12tr_TR
dc.identifier.pubmed32997808tr_TR
dc.identifier.scopus2-s2.0-85092593379tr_TR
dc.identifier.startpage3124tr_TR
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1111/all.14607
dc.identifier.urihttps://doi.org/10.1111/all.14607
dc.identifier.urihttp://hdl.handle.net/11452/29554
dc.identifier.volume75tr_TR
dc.identifier.wos000577623000001tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalAllergy: European Journal of Allergy and Clinical Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAsthma biomarkersen_US
dc.subjectAsthma phenotypesen_US
dc.subjectBiological therapeuticsen_US
dc.subjectComorbiditiesen_US
dc.subjectCovid-19en_US
dc.subjectAllergen immunotherapyen_US
dc.subjectArginase inhibitorsen_US
dc.subjectBlood eosinophilsen_US
dc.subjectEeeaci guidelinesen_US
dc.subjectFood allergyen_US
dc.subjectRhinitsen_US
dc.subjectManagementen_US
dc.subjectOmalizumaben_US
dc.subjectPathologyen_US
dc.subjectParadigmen_US
dc.subjectAllergyen_US
dc.subjectImmunologyen_US
dc.subject.emtreeBiological markeren_US
dc.subject.emtreeProteinen_US
dc.subject.emtreeBiological markeren_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAllergic diseaseen_US
dc.subject.emtreeAsthmaen_US
dc.subject.emtreeChilden_US
dc.subject.emtreeComorbidityen_US
dc.subject.emtreeCoronavirus disease 2019en_US
dc.subject.emtreeDietary supplementen_US
dc.subject.emtreeDisease severityen_US
dc.subject.emtreeDysbiosisen_US
dc.subject.emtreeEnvironmenten_US
dc.subject.emtreeEnvironmental exposureen_US
dc.subject.emtreeEpigeneticsen_US
dc.subject.emtreeExposomeen_US
dc.subject.emtreeHeredityen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeObesityen_US
dc.subject.emtreePandemicen_US
dc.subject.emtreePersonalized medicineen_US
dc.subject.emtreePhenotypeen_US
dc.subject.emtreePrevalenceen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeReviewen_US
dc.subject.emtreeRisk factoren_US
dc.subject.emtreeSevere acute respiratory syndrome coronavirus 2en_US
dc.subject.emtreeSex differenceen_US
dc.subject.emtreeSignal transductionen_US
dc.subject.emtreeSmokingen_US
dc.subject.emtreeAsthmaen_US
dc.subject.emtreeHypersensitivityen_US
dc.subject.meshAsthmaen_US
dc.subject.meshBiomarkersen_US
dc.subject.meshComorbidityen_US
dc.subject.meshCovid-19en_US
dc.subject.meshDysbiosisen_US
dc.subject.meshExposomeen_US
dc.subject.meshHumansen_US
dc.subject.meshPandemicsen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshPrecision medicineen_US
dc.subject.meshRisk factorsen_US
dc.subject.scopusBenralizumab; Asthma; Fractional Exhaled Nitric Oxideen_US
dc.subject.wosAllergyen_US
dc.subject.wosImmunologyen_US
dc.titleAdvances and recent developments in asthma in 2020en_US
dc.typeArticle
dc.wos.quartileQ1en_US

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