Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness

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dc.contributor.buuauthorSağ, Saim
dc.contributor.buuauthorYıldız, Abdülmecit
dc.contributor.buuauthorGüllülü, Sümeyye
dc.contributor.buuauthorGüngören, Fatih
dc.contributor.buuauthorÖzdemir, Bülent
dc.contributor.buuauthorÇeğilli, Ercan
dc.contributor.buuauthorOruç, Ayşegül
dc.contributor.buuauthorErsoy, Alparslan
dc.contributor.buuauthorGüllülü, Mustafa
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-0710-0923tr_TR
dc.contributor.orcid0000-0001-8404-8252tr_TR
dc.contributor.researcheridAAH-5054-2021tr_TR
dc.contributor.researcheridAAH-4002-2021tr_TR
dc.contributor.researcheridAAA-3163-2021tr_TR
dc.contributor.researcheridAAW-9185-2020tr_TR
dc.contributor.scopusid12140008100tr_TR
dc.contributor.scopusid56256977500tr_TR
dc.contributor.scopusid57204660708tr_TR
dc.contributor.scopusid55747051400tr_TR
dc.contributor.scopusid7004168959tr_TR
dc.contributor.scopusid57144621700tr_TR
dc.contributor.scopusid55133912100tr_TR
dc.contributor.scopusid35612977100tr_TR
dc.contributor.scopusid6602684544tr_TR
dc.date.accessioned2022-11-18T12:16:37Z
dc.date.available2022-11-18T12:16:37Z
dc.date.issued2016-02-16
dc.description.abstractEpicardial adipose tissue thickness (EATT) is suggested as a novel marker of subclinical atherosclerosis. Despite increased carotid intima-media thickness (CIMT) in autosomal dominant polycystic kidney disease (ADPKD) patients, the extent of the relationship between CIMT and EATT is unknown. The main purpose of our study was to evaluate the relation between EATT and CIMT in normotensive ADPKD patients with well-preserved renal function. Fifty-five normotensive ADPKD patients with normal renal function and 50 healthy control subjects were included in the study. EATT and CIMT were measured by echocardiography in all subjects. Correlation between EATT and CIMT was evaluated in ADPKD patients, while multivariate linear regression analysis was performed to determine factors predicting EATT and CIMT. ADPKD patients had significantly higher levels CIMT [0.7 (0.4-1.2) vs. 0.5 (0.4-0.8) mm, p < 0.001] and EATT (6.8 +/- 2.7 vs. 4.8 +/- 1.2 mm, p < 0.001) as compared with control subjects. Significant positive correlation was found between EATT and CIMT (r = 0.58, p < 0.001). Higher CRP levels (OR 54.7, 95 % CI 37.44-72.01, p < 0.001) and having ADPKD (OR 10.2, 95 % CI 2.53-17.86, p = 0.01) were the only independent factors associated with a higher EATT. A higher age (OR 0.35, 95 % CI -0.02 to 0.71, p = 0.06) tended to be independently associated with a higher EATT. In conclusion, our findings suggest that EATT, being simply measured by echocardiography and correlated with CIMT, can be used to detect subclinical atherosclerosis in normotensive ADPKD patients.en_US
dc.identifier.citationSağ, S. vd. (2016). "Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness". SpringerPlus, 5, 1-7.en_US
dc.identifier.endpage7tr_TR
dc.identifier.issn2193-1801
dc.identifier.pubmed27026905tr_TR
dc.identifier.scopus2-s2.0-84959306803tr_TR
dc.identifier.startpage1tr_TR
dc.identifier.urihttps://doi.org/10.1186/s40064-016-1871-8
dc.identifier.urihttps://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4771685&blobtype=pdf
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771685/
dc.identifier.urihttp://hdl.handle.net/11452/29490
dc.identifier.volume5tr_TR
dc.identifier.wos000371417200005tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.journalSpringerPlusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectScience & technology - other topicsen_US
dc.subjectAutosomal dominant polycystic kidney diseaseen_US
dc.subjectPreserved renal functionen_US
dc.subjectEarly atherosclerosisen_US
dc.subjectEpicardial adipose tissue thicknessen_US
dc.subjectCarotid intima-media thicknessen_US
dc.subjectLeft-ventricular hypertrophyen_US
dc.subjectFat thicknessen_US
dc.subjectEndothelial dysfunctionen_US
dc.subjectVisceral adiposityen_US
dc.subjectEchocardiographyen_US
dc.subjectHemodialysisen_US
dc.subjectAssociationen_US
dc.subjectPentraxin-3en_US
dc.subjectMassen_US
dc.subject.scopusFat Thickness; Adipose Tissues; Coronary Artery Diseaseen_US
dc.subject.wosMultidisciplinary sciencesen_US
dc.titleEarly atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thicknessen_US
dc.typeArticle

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