Long noncoding RNA MALAT1 may be a prognostic biomarker in IDH1/2 wild-type primary glioblastomas

dc.contributor.authorTezcan, Gülçin
dc.contributor.buuauthorArgadal, Ömer Gökay
dc.contributor.buuauthorMutlu, Melis
dc.contributor.buuauthorAksoy, Seçil
dc.contributor.buuauthorKocaeli, Hasan
dc.contributor.buuauthorTunca, Berrin
dc.contributor.buuauthorCivan, Muhammet Nafi
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorCecener, Gülşah
dc.contributor.buuauthorBekar, Ahmet
dc.contributor.buuauthorTaşkapılıoğlu, M. Özgür
dc.contributor.buuauthorTekin, Çağla
dc.contributor.buuauthorTezcan, Gülçin
dc.contributor.buuauthorTolunay, Şahine
dc.contributor.departmentBursaUludağ Üniversitesi/Tıp Fakültesi/Nöroşirürji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-3760-9755tr_TR
dc.contributor.orcid0000-0002-1619-6680tr_TR
dc.contributor.orcid0000-0001-7904-883Xtr_TR
dc.contributor.orcid0000-0002-3820-424Xtr_TR
dc.contributor.orcid0000-0001-5472-9065tr_TR
dc.contributor.researcheridFPB-0403-2022tr_TR
dc.contributor.researcheridCCA-2925-2022tr_TR
dc.contributor.researcheridFDK-3229-2022tr_TR
dc.contributor.researcheridCMP-5265-2022tr_TR
dc.contributor.researcheridCGB-7869-2022tr_TR
dc.contributor.researcheridGDC-6329-2022tr_TR
dc.contributor.researcheridAAH-3843-2020tr_TR
dc.contributor.researcheridAAI-1612-2021tr_TR
dc.contributor.scopusid57214765002tr_TR
dc.contributor.scopusid57212065763tr_TR
dc.contributor.scopusid57193933334tr_TR
dc.contributor.scopusid6603500567tr_TR
dc.contributor.scopusid6602965754tr_TR
dc.contributor.scopusid57214763395tr_TR
dc.contributor.scopusid55665145000tr_TR
dc.contributor.scopusid6508156530tr_TR
dc.contributor.scopusid6603677218tr_TR
dc.contributor.scopusid25936798300tr_TR
dc.contributor.scopusid57214764024tr_TR
dc.contributor.scopusid25650627600tr_TR
dc.date.accessioned2024-02-16T12:25:04Z
dc.date.available2024-02-16T12:25:04Z
dc.date.issued2020
dc.description.abstractPrimary glioblastoma (GB) is the most aggressive type of brain tumors. While mutations in isocitrate dehydrogenase (IDH) genes are frequent in secondary GBs and correlate with a better prognosis, most primary GBs are IDH wild-type. Recent studies have shown that the long noncoding RNA metastasis associated lung adenocarcinoma transcript-1 (MALAT1) is associated with aggressive tumor phenotypes in different cancers. Our aim was to clarify the prognostic significance of MALAT1 in IDH1/2 wild-type primary GB tumors. We analyzed IDH1/2 mutation status in 75 patients with primary GB by DNA sequencing. The expression of MALAT1 was detected in the 75 primary GB tissues and 5 normal brain tissues using reverse transcription quantitative PCR (RT-qPCR). The associations between MALAT1 expression, IDH1/2 mutation status, and clinicopathological variables of patients were determined. IDH1 (R132H) mutation was observed in 5/75 primary GBs. IDH2 (R172H) mutation was not detected in any of our cases. MALAT1 expression was significantly upregulated in primary GB vs. normal brain tissues (p = 0.025). Increased MALAT1 expression in IDH1/2 wild-type primary GBs correlated with patient age and tumor localization (p = 0.032 and p = 0.025, respectively). A multivariate analysis showed that high MALAT1 expression was an unfavorable prognostic factor for overall survival (p = 0.034) in IDH1/2 wild-type primary GBs. High MALAT1 expression may have a prognostic role in primary GBs independent of IDH mutations.en_US
dc.identifier.citationArgadal, Ö. G. vd. (2020). "Long noncoding RNA MALAT1 may be a prognostic biomarker in IDH1/2 wild-type primary glioblastomas". Bosnian Journal of Basic Medical Sciences, 20(1), 63-69.en_US
dc.identifier.endpage69tr_TR
dc.identifier.issn1512-8601
dc.identifier.issn1840-4812
dc.identifier.issue1tr_TR
dc.identifier.pubmed31479414tr_TR
dc.identifier.scopus2-s2.0-85079075818tr_TR
dc.identifier.startpage63tr_TR
dc.identifier.urihttps://doi.org/10.17305/bjbms.2019.4297en_US
dc.identifier.urihttps://www.bjbms.org/ojs/index.php/bjbms/article/view/4297en_US
dc.identifier.urihttps://hdl.handle.net/11452/39821en_US
dc.identifier.volume20tr_TR
dc.identifier.wos000512952000008tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherAssoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevoen_US
dc.relation.bapOUAP(T)-2015/3en_US
dc.relation.collaborationYurt dışı
dc.relation.journalBosnian Journal of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLong noncoding RNAen_US
dc.subjectMALAT1en_US
dc.subjectBiomarkeren_US
dc.subjectPrognosisen_US
dc.subjectIDH1/2en_US
dc.subjectPrimary glioblastomaen_US
dc.subjectIsocitrate dehydrogenaseen_US
dc.subjectHypermethylationen_US
dc.subjectResearch & experimental medicineen_US
dc.subject.emtreeIDH1 protein, humanen_US
dc.subject.emtreeIsocitrate dehydrogenaseen_US
dc.subject.emtreeIsocitrate dehydrogenase 2en_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLong untranslated RNAen_US
dc.subject.emtreeMALAT1 long non-coding RNA, humanen_US
dc.subject.emtreeMessenger RNAen_US
dc.subject.emtreeTumor markeren_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeBrain tumoren_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGeneticsen_US
dc.subject.emtreeGlioblastomaen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeMutationen_US
dc.subject.emtreeRetrospective studyen_US
dc.subject.emtreeReverse transcription polymerase chain reactionen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBiomarkers, tumoren_US
dc.subject.meshBrain neoplasmsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlioblastomaen_US
dc.subject.meshHumansen_US
dc.subject.meshIsocitrate dehydrogenaseen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMutationen_US
dc.subject.meshRetrospective studiesen_US
dc.subject.meshReverse transcriptase polymerase chain reactionen_US
dc.subject.meshRNAen_US
dc.subject.meshLong noncodingen_US
dc.subject.meshRNA, messengeren_US
dc.subject.scopusIsocitrate Dehydrogenase; Mutation; Epidermal Growth Factor Receptor VIIIen_US
dc.subject.wosMedicine, research & experimentalen_US
dc.titleLong noncoding RNA MALAT1 may be a prognostic biomarker in IDH1/2 wild-type primary glioblastomasen_US
dc.typeArticleen_US
dc.wos.quartileQ3en_US

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