Publication:
Giving uridine and/or docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups

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dc.contributor.authorMarzloff, George
dc.contributor.authorSakamoto, Toshimasa
dc.contributor.authorWurtman, Richard J.
dc.contributor.buuauthorCansev, Mehmet
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFarmakoloji ve Klinik Farmakoloji Ana Bilim Dalı
dc.contributor.scopusid8872816100
dc.contributor.scopusid7004271086
dc.date.accessioned2021-11-29T10:49:00Z
dc.date.available2021-11-29T10:49:00Z
dc.date.issued2009-04
dc.description.abstractDeveloping neurons synthesize substantial quantities of membrane phospholipids in producing new synapses. We investigated the effects of maternal uridine (as uridine-5′-monophosphate) and docosahexaenoic acid supplementation on pups' brain phospholipids, synaptic proteins and dendritic spine densities. Dams consumed neither, 1 or both compounds for 10 days before parturition and 20 days while nursing. By day 21, brains of weanlings receiving both exhibited significant increases in membrane phosphatides, various pre- and postsynaptic proteins (synapsin-1, mGluR1, PSD-95), and in hippocampal dendritic spine densities. Administering these phosphatide precursors to lactating mothers or infants could be useful for treating developmental disorders characterized by deficient synapses.
dc.description.sponsorshipNational Institute of Mental Health (R37MH028783)
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA (R01MH028783)
dc.description.sponsorshipMetabolism Charitable Trust
dc.description.sponsorshipCenter for Brain Sciences
dc.identifier.citationCansev, M. vd. (2009). "Giving uridine and/or docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups". Developmental Neuroscience, 31(3), 181-192.
dc.identifier.endpage192
dc.identifier.issn03785866
dc.identifier.issue3
dc.identifier.pubmed19145070
dc.identifier.scopus2-s2.0-67649111166
dc.identifier.startpage181
dc.identifier.urihttps://doi.org/10.1159/000193394
dc.identifier.urihttps://www.karger.com/Article/Abstract/193394
dc.identifier.urihttp://hdl.handle.net/11452/22851
dc.identifier.volume31
dc.identifier.wos000265862500002
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherKarger
dc.relation.collaborationYurt dışı
dc.relation.collaborationSanayi
dc.relation.journalDevelopmental Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDendritic spines
dc.subjectDevelopment
dc.subjectDocosahexaenoic acid
dc.subjectInfant nutrition
dc.subjectMembrane phosphatides
dc.subjectSynaptic proteins
dc.subjectSynaptogenesis
dc.subjectUridine
dc.subjectPolyunsaturated fatty-acids
dc.subjectNucleoside transporter family
dc.subjectCdp-choline
dc.subjectArachidonic-acid
dc.subjectDendritic spines
dc.subjectBreast-milk
dc.subjectPheochromocytoma cells
dc.subjectNeurite outgrowth
dc.subjectFetal-development
dc.subjectDietary choline
dc.subjectDevelopmental biology
dc.subjectNeurosciences & neurology
dc.subject.emtreeDocosahexaenoic acid
dc.subject.emtreePhospholipid
dc.subject.emtreePostsynaptic density protein 95
dc.subject.emtreeSynapsin I
dc.subject.emtreeUridine phosphate
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal tissue
dc.subject.emtreeArticle
dc.subject.emtreeBirth
dc.subject.emtreeBrain
dc.subject.emtreeBrain development
dc.subject.emtreeBreast feeding
dc.subject.emtreeControlled study
dc.subject.emtreeDendritic spine
dc.subject.emtreeDrug effect
dc.subject.emtreeDrug mechanism
dc.subject.emtreeFemale
dc.subject.emtreeFetus
dc.subject.emtreeHippocampus
dc.subject.emtreeLactation
dc.subject.emtreeMaternal nutrition
dc.subject.emtreeNewborn
dc.subject.emtreeNonhuman
dc.subject.emtreePregnancy
dc.subject.emtreePriority journal
dc.subject.emtreeRat
dc.subject.emtreeSupplementation
dc.subject.emtreeSynapse
dc.subject.meshAdministration, oral
dc.subject.meshAnimals
dc.subject.meshAnimals, newborn
dc.subject.meshBlotting, western
dc.subject.meshBrain
dc.subject.meshBrain chemistry
dc.subject.meshDendrites
dc.subject.meshDietary supplements
dc.subject.meshDocosahexaenoic acids
dc.subject.meshFemale
dc.subject.meshPhospholipids
dc.subject.meshPregnancy
dc.subject.meshRats
dc.subject.meshRats, sprague-dawley
dc.subject.meshSynapses
dc.subject.meshUridine
dc.subject.scopusCholine Phosphate Cytidylyltransferase; Phosphatidylcholines; Citicoline
dc.subject.wosDevelopmental biology
dc.subject.wosNeurosciences
dc.titleGiving uridine and/or docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atScopus

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