Giving uridine and/or docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups

dc.contributor.authorMarzloff, George
dc.contributor.authorSakamoto, Toshimasa
dc.contributor.authorWurtman, Richard J.
dc.contributor.buuauthorCansev, Mehmet
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.scopusid8872816100tr_TR
dc.contributor.scopusid7004271086tr_TR
dc.date.accessioned2021-11-29T10:49:00Z
dc.date.available2021-11-29T10:49:00Z
dc.date.issued2009-04
dc.description.abstractDeveloping neurons synthesize substantial quantities of membrane phospholipids in producing new synapses. We investigated the effects of maternal uridine (as uridine-5′-monophosphate) and docosahexaenoic acid supplementation on pups' brain phospholipids, synaptic proteins and dendritic spine densities. Dams consumed neither, 1 or both compounds for 10 days before parturition and 20 days while nursing. By day 21, brains of weanlings receiving both exhibited significant increases in membrane phosphatides, various pre- and postsynaptic proteins (synapsin-1, mGluR1, PSD-95), and in hippocampal dendritic spine densities. Administering these phosphatide precursors to lactating mothers or infants could be useful for treating developmental disorders characterized by deficient synapses.tr_TR
dc.description.sponsorshipNational Institute of Mental Health (R37MH028783)tr_TR
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA (R01MH028783)tr_TR
dc.description.sponsorshipMetabolism Charitable Trusttr_TR
dc.description.sponsorshipCenter for Brain Sciencestr_TR
dc.identifier.citationCansev, M. vd. (2009). "Giving uridine and/or docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups". Developmental Neuroscience, 31(3), 181-192.tr_TR
dc.identifier.endpage192tr_TR
dc.identifier.issn03785866
dc.identifier.issue3tr_TR
dc.identifier.pubmed19145070tr_TR
dc.identifier.scopus2-s2.0-67649111166tr_TR
dc.identifier.startpage181tr_TR
dc.identifier.urihttps://doi.org/10.1159/000193394
dc.identifier.urihttps://www.karger.com/Article/Abstract/193394
dc.identifier.urihttp://hdl.handle.net/11452/22851
dc.identifier.volume31tr_TR
dc.identifier.wos000265862500002tr_TR
dc.indexed.pubmedPubmedtr_TR
dc.indexed.scopusScopustr_TR
dc.indexed.wosSCIEtr_TR
dc.language.isoentr_TR
dc.publisherKargertr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalDevelopmental Neurosciencetr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccesstr_TR
dc.subjectDendritic spinestr_TR
dc.subjectDevelopmenttr_TR
dc.subjectDocosahexaenoic acidtr_TR
dc.subjectInfant nutritiontr_TR
dc.subjectMembrane phosphatidestr_TR
dc.subjectSynaptic proteinstr_TR
dc.subjectSynaptogenesistr_TR
dc.subjectUridinetr_TR
dc.subjectPolyunsaturated fatty-acidstr_TR
dc.subjectNucleoside transporter familytr_TR
dc.subjectCdp-cholinetr_TR
dc.subjectArachidonic-acidtr_TR
dc.subjectDendritic spinestr_TR
dc.subjectBreast-milktr_TR
dc.subjectPheochromocytoma cellstr_TR
dc.subjectNeurite outgrowthtr_TR
dc.subjectFetal-developmenttr_TR
dc.subjectDietary cholinetr_TR
dc.subjectDevelopmental biologytr_TR
dc.subjectNeurosciences & neurologytr_TR
dc.subject.emtreeDocosahexaenoic acidtr_TR
dc.subject.emtreePhospholipidtr_TR
dc.subject.emtreePostsynaptic density protein 95tr_TR
dc.subject.emtreeSynapsin Itr_TR
dc.subject.emtreeUridine phosphatetr_TR
dc.subject.emtreeAnimal experimenttr_TR
dc.subject.emtreeAnimal tissuetr_TR
dc.subject.emtreeArticletr_TR
dc.subject.emtreeBirthtr_TR
dc.subject.emtreeBraintr_TR
dc.subject.emtreeBrain developmenttr_TR
dc.subject.emtreeBreast feedingtr_TR
dc.subject.emtreeControlled studytr_TR
dc.subject.emtreeDendritic spinetr_TR
dc.subject.emtreeDrug effecttr_TR
dc.subject.emtreeDrug mechanismtr_TR
dc.subject.emtreeFemaletr_TR
dc.subject.emtreeFetustr_TR
dc.subject.emtreeHippocampustr_TR
dc.subject.emtreeLactationtr_TR
dc.subject.emtreeMaternal nutritiontr_TR
dc.subject.emtreeNewborntr_TR
dc.subject.emtreeNonhumantr_TR
dc.subject.emtreePregnancytr_TR
dc.subject.emtreePriority journaltr_TR
dc.subject.emtreeRattr_TR
dc.subject.emtreeSupplementationtr_TR
dc.subject.emtreeSynapsetr_TR
dc.subject.meshAdministration, oraltr_TR
dc.subject.meshAnimalstr_TR
dc.subject.meshAnimals, newborntr_TR
dc.subject.meshBlotting, westerntr_TR
dc.subject.meshBraintr_TR
dc.subject.meshBrain chemistrytr_TR
dc.subject.meshDendritestr_TR
dc.subject.meshDietary supplementstr_TR
dc.subject.meshDocosahexaenoic acidstr_TR
dc.subject.meshFemaletr_TR
dc.subject.meshPhospholipidstr_TR
dc.subject.meshPregnancytr_TR
dc.subject.meshRatstr_TR
dc.subject.meshRats, sprague-dawleytr_TR
dc.subject.meshSynapsestr_TR
dc.subject.meshUridinetr_TR
dc.subject.scopusCholine Phosphate Cytidylyltransferase; Phosphatidylcholines; Citicolinetr_TR
dc.subject.wosDevelopmental biologytr_TR
dc.subject.wosNeurosciencestr_TR
dc.titleGiving uridine and/or docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pupstr_TR
dc.typeArticle
dc.wos.quartileQ3tr_TR

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