Effect of hypothyroidism on the NO/cGMP pathway of corpus cavernosum in rabbits

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dc.contributor.authorBahçıvan, İhsan
dc.contributor.authorYıldırım, M. Kemal
dc.contributor.authorSaraç, Bülent
dc.contributor.authorKaya, Tijen
dc.contributor.buuauthorKılıçarslan, Hakan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi.tr_TR
dc.contributor.scopusid56007473800tr_TR
dc.date.accessioned2021-12-22T07:05:22Z
dc.date.available2021-12-22T07:05:22Z
dc.date.issued2006-09
dc.description.abstractIntroduction. The incidence of hormonal dysfunction as a cause of impotence remains controversial. However, several recent studies have reported evidence of hormonal abnormalities in 25-35% of impotent men. Hypothyroidism has been reported to occur in 6% of impotent men. There is some evidence suggesting that hypothyroidism may be a cause of impotence. Aim. We aimed to investigate the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway in hypothyroidism in an experimental rabbit model and compared hypothyroid rabbits with controls to evaluate the possible involvement of the NO/cGMP pathway. Methods. The study comprised 20 male New Zealand white rabbits. The rabbits were divided into two equal groups. The first group had hypothyroidism induced surgically by thyroidectomy for 6 weeks. The second group underwent a sham operation. Results. There was no significant change in the mean body weight of hypothyroid rabbits and controls. Triiodothyronine and thyroxine levels were significantly lower in hypothyroid rabbits. Plasma thyroid-stimulating hormone and prolactin levels were significantly higher in hypothyroid rabbits. Plasma total calcium and parathormone levels remained in the normal range in both groups. Main Outcome Measures. Papaverine-induced concentration-dependent relaxations were similar in both groups. Carbachol-induced relaxation responses decreased in hypothyroid rabbits. There were significant differences between control and hypothyroid rabbits in frequency-dependent relaxations induced by electrical-field stimulation (EFS). YC-1-induced relaxation responses did not change significantly in hypothyroid rabbits. Concentration-dependent relaxations induced by diethylamine (DEA)/NO were similar in both groups. Amrinone-induced relaxation responses did not change significantly in hypothyroid rabbits. Conclusion. Reductions of relaxant responses to EFS and carbachol in hypothyroid rabbits can depend on the decrease of released or synthesized NO from nitrergic nerves and endothelium.tr_TR
dc.identifier.citationKılıçarslan, H. vd. (2006). ''Effect of hypothyroidism on the NO/cGMP pathway of corpus cavernosum in rabbits''. Journal of Sexual Medicine, 3(5), 830-837.en_US
dc.identifier.endpage837tr_TR
dc.identifier.issn1743-6095
dc.identifier.issue5tr_TR
dc.identifier.pubmed16942528tr_TR
dc.identifier.scopus2-s2.0-33747747604&tr_TR
dc.identifier.startpage830tr_TR
dc.identifier.urihttps://doi.org/10.1111/j.1743-6109.2006.00289.x
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S1743609515313904
dc.identifier.urihttp://hdl.handle.net/11452/23439
dc.identifier.volume3tr_TR
dc.identifier.wos000239941600013tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalJournal of Sexual Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUrology & nephrologyen_US
dc.subjectAnimal modelsen_US
dc.subjectEndocrinologic studies of sexual functionen_US
dc.subjectPharmacologic studies in sexual functionen_US
dc.subjectRelaxationen_US
dc.subjectYC-1en_US
dc.subjectSynergistic activationen_US
dc.subjectNoncholinergic neurotransmissionen_US
dc.subjectPenile erectionen_US
dc.subjectNitric-oxideen_US
dc.subjectTissue in-vitroen_US
dc.subjectSmooth-muscle toneen_US
dc.subjectCyclic-nucleotide phosphodiesteraseen_US
dc.subjectSoluble guanylyl cyclaseen_US
dc.subject.emtreeThyroxineen_US
dc.subject.emtreeThyrotropinen_US
dc.subject.emtreeProlactinen_US
dc.subject.emtreeParathyroid hormoneen_US
dc.subject.emtreePapaverineen_US
dc.subject.emtreeNitric oxideen_US
dc.subject.emtreeLiothyronineen_US
dc.subject.emtreeCyclic GMPen_US
dc.subject.emtreeCarbacholen_US
dc.subject.emtreeCalciumen_US
dc.subject.emtreeThyrotropin blood levelen_US
dc.subject.emtreeThyroidectomyen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeParathyroid hormone blood levelen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeImpotenceen_US
dc.subject.emtreeHypothyroidismen_US
dc.subject.emtreeEndotheliumen_US
dc.subject.emtreeElectric fielden_US
dc.subject.emtreeCorpus cavernosumen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeConcentration responseen_US
dc.subject.emtreeCalcium blood levelen_US
dc.subject.emtreeBody weighten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeRabbiten_US
dc.subject.scopusImpotence; Penis Erection; Corpusen_US
dc.subject.wosUrology & nephrologyen_US
dc.titleEffect of hypothyroidism on the NO/cGMP pathway of corpus cavernosum in rabbitsen_US
dc.typeArticle

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