Publication:
Cytidine 5 '-diphosphocholine ameliorates hyperoxic lung injury in a neonatal rat model

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dc.contributor.authorÇetinkaya, Merih
dc.contributor.authorTayman, Cüneyt
dc.contributor.authorÇekmez, Ferhat
dc.contributor.authorCanpolat, Fuat Emre
dc.contributor.authorTunç, Turan
dc.contributor.authorSarıcı, S. Ümit
dc.contributor.buuauthorCansev, Mehmet
dc.contributor.buuauthorKafa, İlker Mustafa
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFarmakoloji Ana Bilim Dalı
dc.contributor.departmentAnatomi Ana Bilim Dalı
dc.contributor.researcheridM-9071-2019
dc.contributor.researcheridAAG-7125-2021
dc.contributor.scopusid8872816100
dc.contributor.scopusid8450193200
dc.date.accessioned2022-08-19T08:08:47Z
dc.date.available2022-08-19T08:08:47Z
dc.date.issued2013-07
dc.description.abstractBACKGROUND: Bronchopulmonary dysplasia (BPD) is an important cause of morbidity. The aim of this study was to evaluate the preventive effect of cytidine 5'-diphosphocholine (CDP-choline) treatment on hyperoxic lung injury in a neonatal rat model. METHODS: A total of 30 newborn pups were divided into control, hyperoxia, and hyperoxia + CDP-choline groups. After birth, pups in the control group were kept in room air and received saline injections, whereas those in hyperoxia and hyperoxia + CDP-choline groups were exposed to 95% O-2 and received daily injections of saline and CDP-choline throughout postnatal day 10, respectively. Histopathological scoring, radial alveolar count, lamellar body membrane protein expression, fibrosis, proinflammatory cytokine levels, lung tissue and bronchoalveolar lavage (BAL) fluid phospholipid content, and apoptosis were evaluated. RESULTS: Hyperoxia-induced severe lung damage was reduced significantly by CDP-choline treatment. Radial alveolar count and lamellar body membrane protein expression were significantly recovered, and the number of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling-positive cells, active caspase-3 expression, and tissue proinflammatory cytokine levels were decreased by CDP-choline administration. Lung tissue and BAL phospholipid contents showed significant increases after COP-choline administration. CONCLUSION: These data show that COP-choline ameliorates hyperoxic lung injury in a neonatal rat model. It may therefore be suggested that CDP-choline may be a novel therapeutic option for the prevention of BPD.
dc.identifier.citationÇetinkaya, M. vd. (2013). "Cytidine 5 '-diphosphocholine ameliorates hyperoxic lung injury in a neonatal rat model". Pediatric Research, 74(1), 26-33.
dc.identifier.endpage33
dc.identifier.issn0031-3998
dc.identifier.issue1
dc.identifier.pubmed23598810
dc.identifier.scopus2-s2.0-84880291831
dc.identifier.startpage26
dc.identifier.urihttps://doi.org/10.1038/pr.2013.68
dc.identifier.urihttps://www.nature.com/articles/pr201368
dc.identifier.urihttp://hdl.handle.net/11452/28279
dc.identifier.volume74
dc.identifier.wos000321795300005
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherSpringernature
dc.relation.collaborationYurt içi
dc.relation.journalPediatric Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPediatrics
dc.subjectNicotinic acetylcholine-receptor
dc.subjectAutonomic nervous-system
dc.subjectBronchopulmonary dysplasia
dc.subjectPreterm infants
dc.subjectCdp-choline
dc.subjectDisaturated phosphatidylcholine
dc.subjectSurfactant
dc.subjectInflammation
dc.subjectApoptosis
dc.subjectPulmonary
dc.subject.emtreeCaspase 3
dc.subject.emtreeCiticoline
dc.subject.emtreeCytokine
dc.subject.emtreeDNA nucleotidylexotransferase
dc.subject.emtreeInterleukin 1beta
dc.subject.emtreeInterleukin 6
dc.subject.emtreeMembrane protein
dc.subject.emtreePhospholipid
dc.subject.emtreeTumor necrosis factor alpha
dc.subject.emtreeAnimal cell
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeAnimal tissue
dc.subject.emtreeAntiinflammatory activity
dc.subject.emtreeApoptosis
dc.subject.emtreeArticle
dc.subject.emtreeControlled study
dc.subject.emtreeCytokine production
dc.subject.emtreeDrug efficacy
dc.subject.emtreeDrug mechanism
dc.subject.emtreeEnzyme activation
dc.subject.emtreeHistopathology
dc.subject.emtreeHyperoxia
dc.subject.emtreeLamellar body
dc.subject.emtreeLipid peroxidation
dc.subject.emtreeLung fibrosis
dc.subject.emtreeLung fluid
dc.subject.emtreeLung homogenate
dc.subject.emtreeLung injury
dc.subject.emtreeLung lavage
dc.subject.emtreeLung parenchyma
dc.subject.emtreeNewborn
dc.subject.emtreeNonhuman
dc.subject.emtreePerinatal period
dc.subject.emtreePriority journal
dc.subject.emtreeProphylaxis
dc.subject.emtreeProtein blood level
dc.subject.emtreeProtein expression
dc.subject.emtreeRat
dc.subject.meshAnimals
dc.subject.meshAnimals, newborn
dc.subject.meshCytidine diphosphate choline
dc.subject.meshDisease models, animal
dc.subject.meshHyperoxia
dc.subject.meshLung injury
dc.subject.meshRats
dc.subject.scopusCiticoline; Brain Ischemia; Glycerylphosphorylcholine
dc.subject.wosPediatrics
dc.titleCytidine 5 '-diphosphocholine ameliorates hyperoxic lung injury in a neonatal rat model
dc.typeArticle
dc.wos.quartileQ1
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Anatomi Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Farmakoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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