Cytidine 5 '-diphosphocholine ameliorates hyperoxic lung injury in a neonatal rat model
dc.contributor.author | Çetinkaya, Merih | |
dc.contributor.author | Tayman, Cüneyt | |
dc.contributor.author | Çekmez, Ferhat | |
dc.contributor.author | Canpolat, Fuat Emre | |
dc.contributor.author | Tunç, Turan | |
dc.contributor.author | Sarıcı, S. Ümit | |
dc.contributor.buuauthor | Cansev, Mehmet | |
dc.contributor.buuauthor | Kafa, İlker Mustafa | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı. | tr_TR |
dc.contributor.researcherid | M-9071-2019 | tr_TR |
dc.contributor.researcherid | AAG-7125-2021 | tr_TR |
dc.contributor.scopusid | 8872816100 | tr_TR |
dc.contributor.scopusid | 8450193200 | tr_TR |
dc.date.accessioned | 2022-08-19T08:08:47Z | |
dc.date.available | 2022-08-19T08:08:47Z | |
dc.date.issued | 2013-07 | |
dc.description.abstract | BACKGROUND: Bronchopulmonary dysplasia (BPD) is an important cause of morbidity. The aim of this study was to evaluate the preventive effect of cytidine 5'-diphosphocholine (CDP-choline) treatment on hyperoxic lung injury in a neonatal rat model. METHODS: A total of 30 newborn pups were divided into control, hyperoxia, and hyperoxia + CDP-choline groups. After birth, pups in the control group were kept in room air and received saline injections, whereas those in hyperoxia and hyperoxia + CDP-choline groups were exposed to 95% O-2 and received daily injections of saline and CDP-choline throughout postnatal day 10, respectively. Histopathological scoring, radial alveolar count, lamellar body membrane protein expression, fibrosis, proinflammatory cytokine levels, lung tissue and bronchoalveolar lavage (BAL) fluid phospholipid content, and apoptosis were evaluated. RESULTS: Hyperoxia-induced severe lung damage was reduced significantly by CDP-choline treatment. Radial alveolar count and lamellar body membrane protein expression were significantly recovered, and the number of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling-positive cells, active caspase-3 expression, and tissue proinflammatory cytokine levels were decreased by CDP-choline administration. Lung tissue and BAL phospholipid contents showed significant increases after COP-choline administration. CONCLUSION: These data show that COP-choline ameliorates hyperoxic lung injury in a neonatal rat model. It may therefore be suggested that CDP-choline may be a novel therapeutic option for the prevention of BPD. | en_US |
dc.identifier.citation | Çetinkaya, M. vd. (2013). "Cytidine 5 '-diphosphocholine ameliorates hyperoxic lung injury in a neonatal rat model". Pediatric Research, 74(1), 26-33. | en_US |
dc.identifier.endpage | 33 | tr_TR |
dc.identifier.issn | 0031-3998 | |
dc.identifier.issue | 1 | tr_TR |
dc.identifier.pubmed | 23598810 | tr_TR |
dc.identifier.scopus | 2-s2.0-84880291831 | tr_TR |
dc.identifier.startpage | 26 | tr_TR |
dc.identifier.uri | https://doi.org/10.1038/pr.2013.68 | |
dc.identifier.uri | https://www.nature.com/articles/pr201368 | |
dc.identifier.uri | http://hdl.handle.net/11452/28279 | |
dc.identifier.volume | 74 | tr_TR |
dc.identifier.wos | 000321795300005 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springernature | en_US |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.journal | Pediatric Research | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Pediatrics | en_US |
dc.subject | Nicotinic acetylcholine-receptor | en_US |
dc.subject | Autonomic nervous-system | en_US |
dc.subject | Bronchopulmonary dysplasia | en_US |
dc.subject | Preterm infants | en_US |
dc.subject | Cdp-choline | en_US |
dc.subject | Disaturated phosphatidylcholine | en_US |
dc.subject | Surfactant | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Pulmonary | en_US |
dc.subject.emtree | Caspase 3 | en_US |
dc.subject.emtree | Citicoline | en_US |
dc.subject.emtree | Cytokine | en_US |
dc.subject.emtree | DNA nucleotidylexotransferase | en_US |
dc.subject.emtree | Interleukin 1beta | en_US |
dc.subject.emtree | Interleukin 6 | en_US |
dc.subject.emtree | Membrane protein | en_US |
dc.subject.emtree | Phospholipid | en_US |
dc.subject.emtree | Tumor necrosis factor alpha | en_US |
dc.subject.emtree | Animal cell | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Animal tissue | en_US |
dc.subject.emtree | Antiinflammatory activity | en_US |
dc.subject.emtree | Apoptosis | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Cytokine production | en_US |
dc.subject.emtree | Drug efficacy | en_US |
dc.subject.emtree | Drug mechanism | en_US |
dc.subject.emtree | Enzyme activation | en_US |
dc.subject.emtree | Histopathology | en_US |
dc.subject.emtree | Hyperoxia | en_US |
dc.subject.emtree | Lamellar body | en_US |
dc.subject.emtree | Lipid peroxidation | en_US |
dc.subject.emtree | Lung fibrosis | en_US |
dc.subject.emtree | Lung fluid | en_US |
dc.subject.emtree | Lung homogenate | en_US |
dc.subject.emtree | Lung injury | en_US |
dc.subject.emtree | Lung lavage | en_US |
dc.subject.emtree | Lung parenchyma | en_US |
dc.subject.emtree | Newborn | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Perinatal period | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Prophylaxis | en_US |
dc.subject.emtree | Protein blood level | en_US |
dc.subject.emtree | Protein expression | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Animals, newborn | en_US |
dc.subject.mesh | Cytidine diphosphate choline | en_US |
dc.subject.mesh | Disease models, animal | en_US |
dc.subject.mesh | Hyperoxia | en_US |
dc.subject.mesh | Lung injury | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.scopus | Citicoline; Brain Ischemia; Glycerylphosphorylcholine | en_US |
dc.subject.wos | Pediatrics | en_US |
dc.title | Cytidine 5 '-diphosphocholine ameliorates hyperoxic lung injury in a neonatal rat model | en_US |
dc.type | Article | |
dc.wos.quartile | Q1 | en_US |