Higher serum nitrate levels are associated with poor survival in lung cancer patients

dc.contributor.buuauthorÇolakoğulları, Mukaddes
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.buuauthorYılmaztepe, Arzu
dc.contributor.buuauthorOcakoğlu, Gökhan
dc.contributor.buuauthorYılmaz, Meryem
dc.contributor.buuauthorKaradağ, Mehmet
dc.contributor.buuauthorTokullugil, Asuman
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları ve Tüberküloz Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0463-6818tr_TR
dc.contributor.orcid0000-0002-9027-1132tr_TR
dc.contributor.researcheridA-5841-2017tr_TR
dc.contributor.researcheridAAG-8744-2021tr_TR
dc.contributor.researcheridK-5792-2018tr_TR
dc.contributor.researcheridAAH-5180-2021tr_TR
dc.contributor.scopusid14423975800tr_TR
dc.contributor.scopusid6602927353tr_TR
dc.contributor.scopusid8606136100tr_TR
dc.contributor.scopusid15832295800tr_TR
dc.contributor.scopusid57197051873tr_TR
dc.contributor.scopusid6601970351tr_TR
dc.contributor.scopusid6507662010tr_TR
dc.date.accessioned2021-11-26T06:19:40Z
dc.date.available2021-11-26T06:19:40Z
dc.date.issued2006
dc.description.abstractObjectives: Angiogenic factors induce tumour growth and angiogenesis which leads to tumour metastasis and a poor survival rate. This study aimed to assess the possible roles of nitric oxide (NO) and vascular endothelial growth factor-A (VEGF-A) in the overall survival of patients with late stage lung cancer. Design and methods: The study was carried out with primary lung carcinoma patients (n = 31) and healthy controls (n = 15). Pre- and post-cisplatin-based chemotherapy serum nitrite/nitrate levels were measured as nitrite after enzymatic conversion followed by Griess reaction and serum VEGF-A analysis was performed using ELISA. After patient follow-up, survival rates were calculated by using the Kaplan-Meier method [Dudek et al. Cancer Invest 2005; 23(3):193-200]. Results: The serum nitrite/nitrate and VEGF-A levels of lung cancer patients and the control group were 93.7 +/- 48.9 and 63.7 +/- 32.2 PM (p=0.018), and 620 +/- 491 and 255 +/- 157 pg/mL (p = 0.001), respectively, High nitrite/nitrate (> 67.2 mu M) concentration had statistically significant effects on overall survival (Cox analysis, p = 0.026). The overall survival of the lung cancer patients with higher serum nitrate concentrations was significantly less than the ones with lower serum nitrite/nitrate (Kaplan-Meier survival functions test, log rank significance = 0.0007). Conclusion: Our results suggest that having a high serum nitrite/nitrate concentration is a strong indicator of poor survival for late stage lung cancer patients. However, this conclusion deserves to be elucidated further by using a larger sample size.en_US
dc.identifier.citationÇolakoğulları, M. vd. (2006). ''Higher serum nitrate levels are associated with poor survival in lung cancer patients''. Clinical Biochemistry, 39(9), 898-903.en_US
dc.identifier.endpage903tr_TR
dc.identifier.issn0009-9120
dc.identifier.issn1873-2933
dc.identifier.issue9tr_TR
dc.identifier.pubmed16919616tr_TR
dc.identifier.scopus2-s2.0-33748437046tr_TR
dc.identifier.startpage898tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.clinbiochem.2006.06.008
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0009912006002153
dc.identifier.urihttp://hdl.handle.net/11452/22805
dc.identifier.volume39tr_TR
dc.identifier.wos000240820400007tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Scienceen_US
dc.relation.journalClinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMedical laboratory technologyen_US
dc.subjectVascular endothelial growth factor-A (VEGF-A)en_US
dc.subjectSurvivalen_US
dc.subjectSerum nitrite/nitrateen_US
dc.subjectNitric oxide (NO)en_US
dc.subjectLung canceren_US
dc.subjectActivationen_US
dc.subjectRolesen_US
dc.subjectCisplatinen_US
dc.subjectMetastasisen_US
dc.subjectExpressionen_US
dc.subjectAngiogenesisen_US
dc.subjectSmall-cellen_US
dc.subjectP53 gene mutationen_US
dc.subjectNitric-oxide synthaseen_US
dc.subjectEndothelial growth-factoren_US
dc.subject.emtreeVasculotropin Aen_US
dc.subject.emtreeNitriteen_US
dc.subject.emtreeNitric oxideen_US
dc.subject.emtreeNitrateen_US
dc.subject.emtreeCisplatinen_US
dc.subject.emtreeAngiogenic factoren_US
dc.subject.emtreeTurkey (republic)en_US
dc.subject.emtreeSurvival rateen_US
dc.subject.emtreeReaction analysisen_US
dc.subject.emtreeProportional hazards modelen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeOverall survivalen_US
dc.subject.emtreeMetastasisen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeLung canceren_US
dc.subject.emtreeLog rank testen_US
dc.subject.emtreeKaplan meier methoden_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeGriess reactionen_US
dc.subject.emtreeFollow upen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeEnzyme linked immunosorbent assayen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeChemical reactionen_US
dc.subject.emtreeCancer survivalen_US
dc.subject.emtreeCancer combination chemotherapyen_US
dc.subject.emtreeCalculationen_US
dc.subject.emtreeBlood levelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAngiogenesisen_US
dc.subject.emtreeAdulten_US
dc.subject.meshVascular endothelial growth factor Aen_US
dc.subject.meshSurvival rateen_US
dc.subject.meshNitritesen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMaleen_US
dc.subject.meshLung neoplasmsen_US
dc.subject.meshHumansen_US
dc.subject.meshFemaleen_US
dc.subject.meshDrug therapyen_US
dc.subject.meshCase-control studiesen_US
dc.subject.meshAgeden_US
dc.subject.scopusInducible Nitric Oxide Synthase; S-Nitroso-N-Acetylpenicillamine; Arginineen_US
dc.subject.wosMedical laboratory technologyen_US
dc.titleHigher serum nitrate levels are associated with poor survival in lung cancer patientsen_US
dc.typeArticle
dc.wos.quartileQ1en_US

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