Low-grade urinary albumin excretion in normotensive/non-diabetic obstructive sleep apnea patients

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dc.contributor.buuauthorUrsavaş, Ahmet
dc.contributor.buuauthorKaradağ, Mehmet
dc.contributor.buuauthorGüllü, Mustafa
dc.contributor.buuauthorDemirdöǧen, Ezgi
dc.contributor.buuauthorCoşkun, Funda
dc.contributor.buuauthorOnart, Seçuk
dc.contributor.buuauthorGözü, Ramazan Oktay
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz-Baş Boyun Cerrahisi Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-7400-9089tr_TR
dc.contributor.orcid0000-0003-3604-8826tr_TR
dc.contributor.orcid0000-0002-9027-1132tr_TR
dc.contributor.researcheridAAI-3169-2021tr_TR
dc.contributor.researcheridAAH-9812-2021tr_TR
dc.contributor.researcheridAAD-1271-2019tr_TR
dc.contributor.researcheridAAG-8744-2021tr_TR
dc.contributor.scopusid8329319900tr_TR
dc.contributor.scopusid6601970351tr_TR
dc.contributor.scopusid6602684544tr_TR
dc.contributor.scopusid14062849300tr_TR
dc.contributor.scopusid21734137500tr_TR
dc.contributor.scopusid7801637934tr_TR
dc.contributor.scopusid15836640800tr_TR
dc.date.accessioned2022-03-08T09:00:52Z
dc.date.available2022-03-08T09:00:52Z
dc.date.issued2008-08
dc.description.abstractPrevious studies have indicated that high levels of urinary albumin excretion (UAE) are associated with an increased incidence of cardiovascular morbidity and mortality. This study examined the association between UAE and obstructive sleep apnea syndrome (OSAS). The study included 35 newly diagnosed OSAS patients and 11 nonapneic controls. Subjects with diabetes mellitus, hypertension, a history of renal failure, cardiac failure, coronary heart disease, collagen tissue disease, high serum creatinine, and urinary infection, and who use angiotensin-converting enzyme inhibitors and were women were excluded from the study. A single void morning urine sample at the baseline examination was used to measure UAE. There were no significant differences in the age, body mass index (BMI), and smoking habits of the OSAS patients and controls. UAE of the OSAS group was significantly higher than that of the control group (23.3 +/- 6.1 mu g/min vs. 6.5 +/- 2.1 mu g/min, respectively; P=0.002). UAE was positively correlated to length of time spent at an oxygen saturation of < 90% (r=0.503, P=0.002) and BMI (r=0.361, P=0.033). Regression analyses (r(2)=0.504, P < 0.0001) showed that the length of time spent at an oxygen saturation of < 90% (P < 0.0001) was risk factor for UAE, independent of age and BMI. Our study supports the notion that low-grade UAE is associated with non-hypertensive/non-diabetic OSAS, independent of age and BMI. Low-grade UAE may be a marker for subclinical vascular damage that predisposes OSAS patients to future cardiovascular disease.en_US
dc.identifier.citationUrsavaş, A. vd. (2008). '' Low-grade urinary albumin excretion in normotensive/non-diabetic obstructive sleep apnea patients''. Sleep and Breathing, 12(3), 217-222.en_US
dc.identifier.endpage222tr_TR
dc.identifier.issn1520-9512
dc.identifier.issn1522-1709
dc.identifier.issue3tr_TR
dc.identifier.pubmed18335264tr_TR
dc.identifier.scopus2-s2.0-47749155671tr_TR
dc.identifier.startpage217tr_TR
dc.identifier.urihttps://doi.org/10.1007/s11325-008-0169-7
dc.identifier.urihttps://link.springer.com/article/10.1007%252Fs11325-008-0169-7
dc.identifier.urihttp://hdl.handle.net/11452/24906
dc.identifier.volume12tr_TR
dc.identifier.wos000257584700003tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.journalSleep and Breathingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectRespiratory systemen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectSleep apneaen_US
dc.subjectUrine albuminen_US
dc.subjectLeft-ventricular hypertrophyen_US
dc.subjectPositive airway pressureen_US
dc.subjectCardiovascular-diseaseen_US
dc.subjectHypertensionen_US
dc.subjectHearten_US
dc.subjectMicroalbuminuriaen_US
dc.subjectRisken_US
dc.subjectProteinuriaen_US
dc.subjectEventsen_US
dc.subjectMenen_US
dc.subject.emtreeAlbuminen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAge distributionen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBody massen_US
dc.subject.emtreeCardiovascular diseaseen_US
dc.subject.emtreeCardiovascular risken_US
dc.subject.emtreeCardiovascular risken_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisease severityen_US
dc.subject.emtreeExposureen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMicroalbuminuriaen_US
dc.subject.emtreeOxygen saturationen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeprotein urine levelen_US
dc.subject.emtreeRisk factoren_US
dc.subject.emtreeSleep apnea syndromeen_US
dc.subject.emtreeSmoking habiten_US
dc.subject.emtreeUrinalysisen_US
dc.subject.emtreeUrinary excretionen_US
dc.subject.meshAlbuminsen_US
dc.subject.meshBlood pressureen_US
dc.subject.meshBody mass Indexen_US
dc.subject.meshCross-sectional studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshSleep apnea, obstructivoen_US
dc.subject.scopusSleep Apnea Syndromes; Polysomnography; Sleep Wake Disordersen_US
dc.subject.wosClinical neurologyen_US
dc.subject.wosRespiratory systemen_US
dc.titleLow-grade urinary albumin excretion in normotensive/non-diabetic obstructive sleep apnea patientsen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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