Investigation of the dose-dependency of citicoline effects on nerve regeneration and functional recovery in a rat model of sciatic nerve injury
dc.contributor.buuauthor | Kaplan, Tolga | |
dc.contributor.buuauthor | Kafa, İlker Mustafa | |
dc.contributor.buuauthor | Cansev, Mehmet | |
dc.contributor.buuauthor | Bekar, Ahmet | |
dc.contributor.buuauthor | Karlı, Necdet | |
dc.contributor.buuauthor | Taşkapılıoğlu, Mevlüt Özgür | |
dc.contributor.buuauthor | Kanar, Fulya | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Beyin ve Sinir Cerrahisi Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0001-5472-9065 | tr_TR |
dc.contributor.researcherid | AAW-5254-2020 | tr_TR |
dc.contributor.researcherid | AAG-7125-2021 | tr_TR |
dc.contributor.researcherid | M-9071-2019 | tr_TR |
dc.contributor.scopusid | 7006761497 | tr_TR |
dc.contributor.scopusid | 8450193200 | tr_TR |
dc.contributor.scopusid | 8872816100 | tr_TR |
dc.contributor.scopusid | 6603677218 | tr_TR |
dc.contributor.scopusid | 6506587942 | tr_TR |
dc.contributor.scopusid | 25936798300 | tr_TR |
dc.contributor.scopusid | 56037464100 | tr_TR |
dc.date.accessioned | 2022-09-15T11:32:47Z | |
dc.date.available | 2022-09-15T11:32:47Z | |
dc.date.issued | 2014-01 | |
dc.description.abstract | AIM: The aim of this study was to investigate the dose dependence of citicoline's previously-reported effects on recovery of peripheral nerve injury. MATERIAL and METHODS: Right sciatic nerves of sixty adult female Wistar Albino rats were incised and primary anastomosis was performed. Rats were then divided into four groups: Control group received 2 ml of saline intraperitoneally, while rats in C-300, C-600 and C-900 groups received 300 mu mol/kg, 600 mu mol/kg and 900 mu mol/kg citicoline dissolved in 2 ml saline, respectively. Rats were tested for sciatic functional index (SFI) on the 4th, 8th and 12th weeks and electrophysiological recordings were obtained on the 12th week. Rats were then sacrificed to investigate nerve adhesions and perform histomorphological examinations. RESULTS:Our results showed that rats in C-600 and C-900 groups had significantly lesser neural adhesion and greater SFI and electrophysiological score than those in the Control and C-300 groups (p<0.05). Mean density and total number of functionally myelinated axons were significantly increased in C-900 group, while perineural scar tissue formation was reduced in all citicoline-treated groups. CONCLUSION: We conclude that citicoline exhibits dose-dependent effects on axonal regeneration and recovery without scar formation in a rat model of peripheral nerve incision and primary anastomosis. | en_US |
dc.description.abstract | AMAÇ: Bu çalışmanın amacı, periferik sinir hasarının iyileşmesinde sitikolinin daha önceden bildirilen doz bağımlı etkisinin araştırılmasıdır. YÖNTEM ve GEREÇLER: Altmış erişkin dişi Wistar Albino sıçanın sağ siyatik sinirleri kesilerek primer anostomoz uygulandı. Sıçanlar dört gruba ayrıldı: Kontrol grubunda 2 ml salin intraperitoneal olarak uygulandı. C-300, C-600 ve C-900 gruplarında sırası ile 300 μmol/kg, 600 μmol/kg ve 900 μmol/kg, 2ml salin içinde çözünmüş sitikolin uygulandı. Sıçanlar 4., 8., 12. haftalarda siyatik fonksiyon indeksi ile değerlendirildiler ve 12. haftada elektrofizyolojik ölçümler yapıldı. Sıçanlar sinir yapışıklığını araştırmak ve histomorfolojik araştırmalar için feda edildiler. BULGULAR: Araştırmamızın sonuçlarına göre, C-600 ve C-900 gruplarındaki sıçanlarda C-300 grubundaki sıçanlara göre belirgin olarak az nöral yapışıklık, daha iyi siyatik fonksiyon indeksi ve elektrofizyolojik sonuçlar elde edilmiştir (p<0,05). C-900 grubunda ortalama yoğunluk ve fonksiyonel myelinli aksonların total sayısında belirgin artış saptanmıştır. Sitikolinle tedavi edilen tüm gruplarda perinöral skar dokusu azalmıştır. SONUÇ: Sitikolin, aksonal rejenerasyonda ve sıçan periferik sinir kesilme ve primer anostomoz modelinde skar dokusu oluşmadan iyileşmede doza bağımlı olarak etki gösterir | tr_TR |
dc.identifier.citation | Kaplan, T. vd. (2014). "Investigation of the dose-dependency of citicoline effects on nerve regeneration and functional recovery in a rat model of sciatic nerve injury". Turkish Neurosurgery, 24(1), 54-62. | tr_TR |
dc.identifier.endpage | 62 | tr_TR |
dc.identifier.issn | 1019-5149 | |
dc.identifier.issue | 1 | tr_TR |
dc.identifier.pubmed | 24535792 | tr_TR |
dc.identifier.scopus | 2-s2.0-84894073364 | tr_TR |
dc.identifier.startpage | 54 | tr_TR |
dc.identifier.uri | https://doi.org/10.5137/1019-5149.JTN.8451-13.0 | |
dc.identifier.uri | http://www.turkishneurosurgery.org.tr/pdf/pdf_JTN_1253.pdf | |
dc.identifier.uri | http://hdl.handle.net/11452/28755 | |
dc.identifier.volume | 24 | tr_TR |
dc.identifier.wos | 000331663300012 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.trdizin | TrDizin | tr_TR |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Türk Nöroloji Derneği | tr_TR |
dc.relation.journal | Turkish Neurosurgery | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Peripheral nerve | en_US |
dc.subject | Citicoline | en_US |
dc.subject | Regeneration | en_US |
dc.subject | Nicotinic acetylcholine-receptors | en_US |
dc.subject | Transient-cerebral ischemia | en_US |
dc.subject | CDP-choline | en_US |
dc.subject | Involvement | en_US |
dc.subject | Repair | en_US |
dc.subject | Metabolites | en_US |
dc.subject | System | en_US |
dc.subject | Phosphocholine | en_US |
dc.subject | Mechanisms | en_US |
dc.subject | Reducion | en_US |
dc.subject | Neurosciences & neurology | en_US |
dc.subject | Surgery | en_US |
dc.subject | Periferik sinir | tr_TR |
dc.subject | Sitikolin | tr_TR |
dc.subject | Rejenerasyon | tr_TR |
dc.subject.emtree | Citicoline | en_US |
dc.subject.emtree | Nootropic agent | en_US |
dc.subject.emtree | Anastomosis | en_US |
dc.subject.emtree | Animal | en_US |
dc.subject.emtree | Animal behavior | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Convalescence | en_US |
dc.subject.emtree | Dose response | en_US |
dc.subject.emtree | Drug effect | en_US |
dc.subject.emtree | Electromyography | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Image processing | en_US |
dc.subject.emtree | Injury | en_US |
dc.subject.emtree | Myelinated nerve | en_US |
dc.subject.emtree | Nerve fiber | en_US |
dc.subject.emtree | Nerve regeneration | en_US |
dc.subject.emtree | Pathology | en_US |
dc.subject.emtree | Physiology | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Scar | en_US |
dc.subject.emtree | Sciatic nerve | en_US |
dc.subject.emtree | Walking | en_US |
dc.subject.emtree | Wistar rat | en_US |
dc.subject.mesh | Anastomosis, surgical | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Axons | en_US |
dc.subject.mesh | Behavior, animal | en_US |
dc.subject.mesh | Cicatrix | en_US |
dc.subject.mesh | Cytidine diphosphate choline | en_US |
dc.subject.mesh | Dose-response relationship, drug | en_US |
dc.subject.mesh | Electromyography | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Image processing | en_US |
dc.subject.mesh | Computer-assisted | en_US |
dc.subject.mesh | Nerve fibers, myelinated | en_US |
dc.subject.mesh | Nerve regeneration | en_US |
dc.subject.mesh | Nootropic agents | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, wistar | en_US |
dc.subject.mesh | Recovery of function | en_US |
dc.subject.mesh | Sciatic nerve | en_US |
dc.subject.mesh | Walking | en_US |
dc.subject.scopus | Citicoline; Brain Ischemia; Glycerylphosphorylcholine | en_US |
dc.subject.wos | Clinical neurology | en_US |
dc.subject.wos | Surgery | en_US |
dc.title | Investigation of the dose-dependency of citicoline effects on nerve regeneration and functional recovery in a rat model of sciatic nerve injury | en_US |
dc.title.alternative | Sıçan siyatik sinir hasarı modelinde sinir rejenerasyonu ve fonksiyonel iyileşmesinde sitikolinin doza bağımlı etkisinin incelenmesi | tr_TR |
dc.type | Article | |
dc.wos.quartile | Q4 | en_US |