Investigation of the dose-dependency of citicoline effects on nerve regeneration and functional recovery in a rat model of sciatic nerve injury

dc.contributor.buuauthorKaplan, Tolga
dc.contributor.buuauthorKafa, İlker Mustafa
dc.contributor.buuauthorCansev, Mehmet
dc.contributor.buuauthorBekar, Ahmet
dc.contributor.buuauthorKarlı, Necdet
dc.contributor.buuauthorTaşkapılıoğlu, Mevlüt Özgür
dc.contributor.buuauthorKanar, Fulya
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Beyin ve Sinir Cerrahisi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-5472-9065tr_TR
dc.contributor.researcheridAAW-5254-2020tr_TR
dc.contributor.researcheridAAG-7125-2021tr_TR
dc.contributor.researcheridM-9071-2019tr_TR
dc.contributor.scopusid7006761497tr_TR
dc.contributor.scopusid8450193200tr_TR
dc.contributor.scopusid8872816100tr_TR
dc.contributor.scopusid6603677218tr_TR
dc.contributor.scopusid6506587942tr_TR
dc.contributor.scopusid25936798300tr_TR
dc.contributor.scopusid56037464100tr_TR
dc.date.accessioned2022-09-15T11:32:47Z
dc.date.available2022-09-15T11:32:47Z
dc.date.issued2014-01
dc.description.abstractAIM: The aim of this study was to investigate the dose dependence of citicoline's previously-reported effects on recovery of peripheral nerve injury. MATERIAL and METHODS: Right sciatic nerves of sixty adult female Wistar Albino rats were incised and primary anastomosis was performed. Rats were then divided into four groups: Control group received 2 ml of saline intraperitoneally, while rats in C-300, C-600 and C-900 groups received 300 mu mol/kg, 600 mu mol/kg and 900 mu mol/kg citicoline dissolved in 2 ml saline, respectively. Rats were tested for sciatic functional index (SFI) on the 4th, 8th and 12th weeks and electrophysiological recordings were obtained on the 12th week. Rats were then sacrificed to investigate nerve adhesions and perform histomorphological examinations. RESULTS:Our results showed that rats in C-600 and C-900 groups had significantly lesser neural adhesion and greater SFI and electrophysiological score than those in the Control and C-300 groups (p<0.05). Mean density and total number of functionally myelinated axons were significantly increased in C-900 group, while perineural scar tissue formation was reduced in all citicoline-treated groups. CONCLUSION: We conclude that citicoline exhibits dose-dependent effects on axonal regeneration and recovery without scar formation in a rat model of peripheral nerve incision and primary anastomosis.en_US
dc.description.abstractAMAÇ: Bu çalışmanın amacı, periferik sinir hasarının iyileşmesinde sitikolinin daha önceden bildirilen doz bağımlı etkisinin araştırılmasıdır. YÖNTEM ve GEREÇLER: Altmış erişkin dişi Wistar Albino sıçanın sağ siyatik sinirleri kesilerek primer anostomoz uygulandı. Sıçanlar dört gruba ayrıldı: Kontrol grubunda 2 ml salin intraperitoneal olarak uygulandı. C-300, C-600 ve C-900 gruplarında sırası ile 300 μmol/kg, 600 μmol/kg ve 900 μmol/kg, 2ml salin içinde çözünmüş sitikolin uygulandı. Sıçanlar 4., 8., 12. haftalarda siyatik fonksiyon indeksi ile değerlendirildiler ve 12. haftada elektrofizyolojik ölçümler yapıldı. Sıçanlar sinir yapışıklığını araştırmak ve histomorfolojik araştırmalar için feda edildiler. BULGULAR: Araştırmamızın sonuçlarına göre, C-600 ve C-900 gruplarındaki sıçanlarda C-300 grubundaki sıçanlara göre belirgin olarak az nöral yapışıklık, daha iyi siyatik fonksiyon indeksi ve elektrofizyolojik sonuçlar elde edilmiştir (p<0,05). C-900 grubunda ortalama yoğunluk ve fonksiyonel myelinli aksonların total sayısında belirgin artış saptanmıştır. Sitikolinle tedavi edilen tüm gruplarda perinöral skar dokusu azalmıştır. SONUÇ: Sitikolin, aksonal rejenerasyonda ve sıçan periferik sinir kesilme ve primer anostomoz modelinde skar dokusu oluşmadan iyileşmede doza bağımlı olarak etki gösterirtr_TR
dc.identifier.citationKaplan, T. vd. (2014). "Investigation of the dose-dependency of citicoline effects on nerve regeneration and functional recovery in a rat model of sciatic nerve injury". Turkish Neurosurgery, 24(1), 54-62.tr_TR
dc.identifier.endpage62tr_TR
dc.identifier.issn1019-5149
dc.identifier.issue1tr_TR
dc.identifier.pubmed24535792tr_TR
dc.identifier.scopus2-s2.0-84894073364tr_TR
dc.identifier.startpage54tr_TR
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.8451-13.0
dc.identifier.urihttp://www.turkishneurosurgery.org.tr/pdf/pdf_JTN_1253.pdf
dc.identifier.urihttp://hdl.handle.net/11452/28755
dc.identifier.volume24tr_TR
dc.identifier.wos000331663300012tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.trdizinTrDizintr_TR
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTürk Nöroloji Derneğitr_TR
dc.relation.journalTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPeripheral nerveen_US
dc.subjectCiticolineen_US
dc.subjectRegenerationen_US
dc.subjectNicotinic acetylcholine-receptorsen_US
dc.subjectTransient-cerebral ischemiaen_US
dc.subjectCDP-cholineen_US
dc.subjectInvolvementen_US
dc.subjectRepairen_US
dc.subjectMetabolitesen_US
dc.subjectSystemen_US
dc.subjectPhosphocholineen_US
dc.subjectMechanismsen_US
dc.subjectReducionen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectSurgeryen_US
dc.subjectPeriferik sinirtr_TR
dc.subjectSitikolintr_TR
dc.subjectRejenerasyontr_TR
dc.subject.emtreeCiticolineen_US
dc.subject.emtreeNootropic agenten_US
dc.subject.emtreeAnastomosisen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeAnimal behavioren_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeConvalescenceen_US
dc.subject.emtreeDose responseen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeElectromyographyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeImage processingen_US
dc.subject.emtreeInjuryen_US
dc.subject.emtreeMyelinated nerveen_US
dc.subject.emtreeNerve fiberen_US
dc.subject.emtreeNerve regenerationen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreePhysiologyen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeScaren_US
dc.subject.emtreeSciatic nerveen_US
dc.subject.emtreeWalkingen_US
dc.subject.emtreeWistar raten_US
dc.subject.meshAnastomosis, surgicalen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAxonsen_US
dc.subject.meshBehavior, animalen_US
dc.subject.meshCicatrixen_US
dc.subject.meshCytidine diphosphate cholineen_US
dc.subject.meshDose-response relationship, drugen_US
dc.subject.meshElectromyographyen_US
dc.subject.meshFemaleen_US
dc.subject.meshImage processingen_US
dc.subject.meshComputer-assisteden_US
dc.subject.meshNerve fibers, myelinateden_US
dc.subject.meshNerve regenerationen_US
dc.subject.meshNootropic agentsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, wistaren_US
dc.subject.meshRecovery of functionen_US
dc.subject.meshSciatic nerveen_US
dc.subject.meshWalkingen_US
dc.subject.scopusCiticoline; Brain Ischemia; Glycerylphosphorylcholineen_US
dc.subject.wosClinical neurologyen_US
dc.subject.wosSurgeryen_US
dc.titleInvestigation of the dose-dependency of citicoline effects on nerve regeneration and functional recovery in a rat model of sciatic nerve injuryen_US
dc.title.alternativeSıçan siyatik sinir hasarı modelinde sinir rejenerasyonu ve fonksiyonel iyileşmesinde sitikolinin doza bağımlı etkisinin incelenmesitr_TR
dc.typeArticle
dc.wos.quartileQ4en_US

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