IL-10 and IL-6 gene polymorphisms as potential host susceptibility factors in Brucellosis

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dc.contributor.authorBaştürk, Bilkay
dc.contributor.buuauthorBudak, Ferah
dc.contributor.buuauthorGöral, Güher
dc.contributor.buuauthorHeper, Yasemin
dc.contributor.buuauthorYılmaz, Emel
dc.contributor.buuauthorAymak, Figen
dc.contributor.buuauthorTöre, Okan
dc.contributor.buuauthorEner, Beyza
dc.contributor.buuauthorOral, Haluk B.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0463-6818tr_TR
dc.contributor.orcid0000-0002-4803-8206tr_TR
dc.contributor.orcid0000-0002-3894-1231tr_TR
dc.contributor.researcheridAAH-6506-2021tr_TR
dc.contributor.researcheridAAG-8523-2021tr_TR
dc.contributor.researcheridK-7285-2012tr_TR
dc.contributor.researcheridF-4657-2014tr_TR
dc.contributor.researcheridA-5841-2017tr_TR
dc.contributor.scopusid6701913697tr_TR
dc.contributor.scopusid6603453166tr_TR
dc.contributor.scopusid56191003300tr_TR
dc.contributor.scopusid22037135100tr_TR
dc.contributor.scopusid16645073100tr_TR
dc.contributor.scopusid6505909596tr_TR
dc.contributor.scopusid15053025300tr_TR
dc.contributor.scopusid7004498001tr_TR
dc.date.accessioned2022-09-06T13:36:25Z
dc.date.available2022-09-06T13:36:25Z
dc.date.issued2007-04
dc.description.abstractSeveral genes encoding for different cytokines may play crucial roles in host susceptibility to Brucellosis, since the cytokine production capacity varies among individuals and depends on the cytokine gene polymorphism. The association of the cytokine gene polymorphisms with the development of Brucellosis was investigated in this study. DNA samples were obtained from a Turkish population of 40 patients with Brucellosis, and 50 healthy control subjects. All genotyping (IL-6, IL10, IFN-γ, TGF-β and TNF-α) experiments were performed using sequence-specific primers PCR (PCR-SSP). When compared to the healthy controls, the frequencies of high/intermediate producing genotypes of IL-10 and high producing genotype of IL-6 were significantly more common in the patient group. These results suggest that IL-10 and IL-6 gene polymorphisms may affect susceptibility to Brucellosis and increase risk of developing the disease. In order to confirm the biological significance of our results, further studies should be performed in larger population groups.en_US
dc.identifier.citationBudak, F. vd. (2007). "IL-10 and IL-6 gene polymorphisms as potential host susceptibility factors in Brucellosis". Cytokine, 38(1), 32-36.en_US
dc.identifier.endpage36tr_TR
dc.identifier.issn10434666
dc.identifier.issue1tr_TR
dc.identifier.pubmed17544674tr_TR
dc.identifier.scopus2-s2.0-34250843998tr_TR
dc.identifier.startpage32tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.cyto.2007.04.008
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1043466607000877
dc.identifier.urihttp://hdl.handle.net/11452/28506
dc.identifier.volume38tr_TR
dc.identifier.wos000248402600005tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherAcademic Pressen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalCytokineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrucellosisen_US
dc.subjectCytokineen_US
dc.subjectGenotypingen_US
dc.subjectIL-10en_US
dc.subjectIL-6en_US
dc.subjectPCR-SSPen_US
dc.subjectNecrosis-factor-alphaen_US
dc.subjectIfn-gamma productıonen_US
dc.subjectPromoter polymorphismen_US
dc.subjectOnline databasesen_US
dc.subjectHuman-diseaseen_US
dc.subjectNitric-oxideen_US
dc.subjectInterferon-gammaen_US
dc.subjectAbortusen_US
dc.subjectAssociationen_US
dc.subjectImmuntyen_US
dc.subject.emtreeDNA polymorphismen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBrucellosisen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCytokine releaseen_US
dc.subject.emtreeInterleukin 10en_US
dc.subject.emtreeGenetic codeen_US
dc.subject.emtreeGenetic risken_US
dc.subject.emtreeGenetic susceptibilityen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreePolymerase chain reactionen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeGamma interferonen_US
dc.subject.emtreeInterleukin 6en_US
dc.subject.emtreeTransforming growth factor betaen_US
dc.subject.emtreeTumor necrosis factor alphaen_US
dc.subject.meshGenetic predisposition to diseaseen_US
dc.subject.meshBrucellosisen_US
dc.subject.meshHumansen_US
dc.subject.meshInterleukin-10en_US
dc.subject.meshInterleukin-6en_US
dc.subject.meshPolymorphism, geneticen_US
dc.subject.meshTurkeyen_US
dc.subject.scopusBrucella Abortus; Zoonosis; Bovine Brucellosisen_US
dc.subject.wosBiochemistry & molecular biologyen_US
dc.subject.wosCell biologyen_US
dc.subject.wosImmunologyen_US
dc.titleIL-10 and IL-6 gene polymorphisms as potential host susceptibility factors in Brucellosisen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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