Glycine N-methyltransferase deficiency: A member of dysmethylating liver disorders?
Date
2016-02-02
Journal Title
Journal ISSN
Volume Title
Publisher
Springer
Abstract
Glycine N-methyltransferase deficiency is an inherited disorder of methionine metabolism, reported so far in only four patients and characterised by permanent hypermethioninemia. This disorder has been considered as probably benign because moderate hepatomegaly in two patients was the only obvious symptom and mild to moderate elevation of aminotransferases the only laboratory abnormality. Our experience with the current novel patient points out that this disease, due to very high hypermethioninemia, is not harmless and that there may be diagnostic pitfalls in interpretation of biochemical hallmarks of the disease. Since the first description of glycine N-methyltransferase deficiency, other disorders of this metabolic pathway affecting the liver have been reported pointing to dysmethylation as the common pathogenetic mechanism. Therefore, we suggest the whole group to be named dysmethylating liver diseases.
Description
Keywords
Endocrinology & metabolism, Genetics & heredity, Glycine-N-methyltransferase deficiency, Hypermethioninemia, Inherited liver disease, Methylation disorders, Adenosylhomocysteine hydrolase deficiency, S-adenosylhomocysteine, Hepatocellular-carcinoma, Methionine metabolism, I/III deficiency, Adenosylmethionine, Disease, Mutation, Enzyme, Mice
Citation
Baric, I. vd. (2017). ''Glycine N-methyltransferase deficiency: A member of dysmethylating liver disorders?''. ed. M. Baumgartner, vd. JIMD Reports, 31, 101-106.