Open-label trial of cyclosporine for vulvar lichen sclerosus
Date
2007-08
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Mosby Elsevier
Abstract
Background: Lichen sclerosus (LS) is a chronic inflammatory disease of skin and mucosal surfaces which is generally difficult to treat.
Objective: We evaluated the efficacy of oral cyclosporine in refractory vulvar LS.
Methods: Five patients with refractory vulvar LS were treated with oral cyclosporine (3-4 mg/kg/d) for 3 months. They were followed up on a monthly basis.
Results: At the end of the treatment, the mean total symptom score regressed significantly and clinical findings such as erythema and erosion showed marked improvement. Mild adverse effects were seen in 3 patients.
Limitations: The patients did not give consent to rebiopsy at the end of the treatment.
Conclusion: Moderate dose of oral cyclosporine could be an effective alternative in the treatment of refractory vulvar LS.
Description
Keywords
Dermatology, Clobetasol
Citation
Başkan, E. B. vd. (2007). "Open-label trial of cyclosporine for vulvar lichen sclerosus". Journal of the American Academy of Dermatology, 57(2), 276-278.