Growth of staphylococcus aureus, Candida albicans, Escherichia coli and Pseudomonas aeruginosa in propofol, thiopental and a 1:1 propofol-thiopental mixture
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Date
2010
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Publisher
Medwell Online
Abstract
Extrinsic contamination of propofol is thought to be a source of postoperative sepsis. Researchers studied growth of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans in propofol, thiopental and in a 1:1 propofol-thiopental mixture. All microorganisms were taken from standard stock cultures. Half of the samples were incubated at 20 degrees C and the rest were stored at 4 degrees C for 120 h. Growth of microorganisms in each solution was compared by counting the number of the Colony-Forming Units (CFUs) at 0, 3, 6, 24, 72 and 120 h. Propofol supported the growth of all four microorganims at both temperatures. In contrast, thiopental and the 1:1 propofol-thiopental mixture exhibited markedly bactericidal properties on E. coli, C. albicans and P. aeruginosa and bacteriostatic effect on S. aureus.
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Keywords
Intravenous anesthetics, Propofol, Thiopental, Mixture, Bacteria, Growth rate, Bacterial-contamination, Microorganisms, Veterinary sciences
Citation
Topal, A. vd. (2010). "Growth of staphylococcus aureus, Candida albicans, Escherichia coli and Pseudomonas aeruginosa in propofol, thiopental and a 1:1 propofol-thiopental mixture". Journal of Animal and Veterinary Advances, 9(10), 1432-1435.