Histological evaluation of wound healing performance of electrospun poly(vinyl alcohol)/sodium alginate as wound dressing in vivo
Date
2014
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Ios Press
Abstract
Poly(vinyl alcohol)/sodium alginate nanofibrous mats were produced by electrospinning method at optimum process parameters. Evaluation of alginate-based electrospun nanofibrous mats as a wound dressing material and their comparison to commercially available wound dressings produced with conventional methods were carried out in vivo. Tissue specimens were examined histopathologically on 4th, 6th, 15th, 21st postoperative days. In contrast to other dressings it was observed that nanofibrous mat could survive on the wound crust in early stages of healing. In terms of epithelization, epidermis characteristics, vascularization and formation of hair follicles, nanofibrous mat showed the best healing performance. This could be explained with presence of nanofibrous mat acting as an artificial skin on the wound region until new tissue regenerated.
Description
Keywords
Electrospinning, Nanofiber, Alginate, Wound dressing, Histological evaluation, In vivo, Normal human keratinocytes, Nanofibrous membrane, Sodium alginate, Fibers, Engineering, Materials science, Artificial organs, Biomaterials, Polyvinyl alcohols, Tissue, Conventional methods, Electrospinning method, Histological evaluation, In-vivo, Post-operative days, Process parameters, Wound dressing materials, Wound dressings, Nanofibers
Citation
Coşkun, G. vd. (2014). "Histological evaluation of wound healing performance of electrospun poly(vinyl alcohol)/sodium alginate as wound dressing in vivo". Bio-Medical Materials and Engineering, 24(2), 1527-1536.