Continuous positive airway pressure therapy improves arterial elasticity in patients with obstructive sleep apnea
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Date
2010-10
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Publisher
W B Saunders CO
Abstract
Background: Reduced arterial elasticity is an important mediator of accelerated atherogenesis and consequent increased cardiovascular morbidity in obstructive sleep apnea (OSA). The aim of our study was to investigate whether continuous positive airway pressure (CPAP) therapy may improve arterial elasticity in subjects with OSA.
Methods: In 44 subjects with OSA, we measured arterial elasticity by applanation tonometry before and after 6 months of treatment with CPAP. Nine OSA+ subjects withdrew from the study.
Results: The 35 patients with OSA who completed the 6-month CPAP treatment showed a marked reduction in both the large artery (LAEI, P = 0.001) and small artery (SAEI, P = 0.009) elasticity indices, independent of potential confounders. In OSA+ subjects who withdrew from the study, SAEI and LAEI did not change significantly over time.
Conclusions: Six months of CPAP therapy improves arterial elasticity in subjects with OSA.
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Keywords
Obstructive sleep apnea syndrome, Endothelial dysfunction, Arterial elasticity, Continuous positive airway pressure, Pulse-wave velocity, Endothelial dysfunction, Nitric-oxide, Stiffness, Atherosclerosis, Association, Moderate, CPAP, Cardiovascular system & cardiology, Respiratory system
Citation
Eryılmaz, S. vd. (2010). "Continuous positive airway pressure therapy improves arterial elasticity in patients with obstructive sleep apnea". Respiratory Medicine, 104(10), 1571-1576.