Clinical outcomes of lung metastasectomy in patients with colorectal cancer

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Date

2012-02-21

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Baishideng Publishing Group

Abstract

AIM: To investigate prognostic factors of survival following curative, non-palliative surgical removal of lung metastases secondary to colorectal cancer (CRC). METHODS: Between 1999 and 2009, a radical metastasectomy with curative intent was performed on lung metastases in 21 patients with CRC (15 male and 6 female; mean age: 57.4 +/- 11.8 years; age range: 29-74 years) who had already undergone primary tumour resection. RESULTS: The mean number of lung metastases ranged from one to five. The mean overall survival was 71 +/- 35 mo (median: 25 mo). After adjusting for potential confounders, multivariable Cox regression analyses predicted only the number of lung metastases (1 vs >= 2; hazard ratio: 7.60, 95% confidence interval: 1.18-17.2, P = 0.03) as an independent predictor of poor survival following lung resection for metastatic CRC. CONCLUSION: Resection of lung metastases is a safe and effective treatment in selected CRC patients with single lung metastases. (C) 2012 Baishideng. All rights reserved.

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Keywords

Gastroenterology & hepatology, Lung metastases, Colorectal cancer, Metastasectomy, Prognostic factors, Survival, Pulmonary metastases, Surgical resection, Prognostic-factors, Carcinoma, Survival, Surgery

Citation

Ölmez, Ö. F. vd. (2012). "Clinical outcomes of lung metastasectomy in patients with colorectal cancer". World Journal of Gastroenterology, 18(7), 662-665.