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Title: Fas antigen (CD95) expression and apoptosis in hepatocytes of patients with chronic viral hepatitis
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Bilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.
Kıyıcı, Murat
Gürel, Selim
Budak, Ferah
Dolar, Enver
Gülten, Macit
Nak, Selim Giray
Memik, Faruk
Keywords: Gastroenterology and hepatology
Chronic viral hepatitis
Fas antigen
Receptor superfamily
Issue Date: Oct-2003
Publisher: Lippincott Williams and Wilkins
Citation: Kıyıcı, M. vd. (2003). “Fas antigen (CD95) expression and apoptosis in hepatocytes of patients with chronic viral hepatitis”. European Journal of Gastroenterology and Hepatology, 15(10), 1079-1084.
Abstract: Background Apoptosis may be defined as programmed cell death. It is involved in the normal development and homeostasis of tissues in multicellular organisms. An increased or decreased rate of apoptosis may lead to a range of diseases. Fas antigen is a cell-surface receptor that induces apoptotic pathways when treated with Fas ligand or anti-Fas antibody. There is increasing evidence that apoptosis plays an important role in the immunopathogenesis of chronic viral hepatitis, in which the Fas antigen-Fas ligand pathway is particularly involved. Methods Fas antigen expression and apoptosis (apoptotic index) were assayed using flow cytometry in the hepatocytes of 27 patients with chronic viral hepatitis. Histopathological activity, scored by Knodell's histological activity index, other histopathological parameters, serum transaminase values and patient age were then compared with apoptotic index and Fas antigen expression. Results Apoptosis and Fas antigen expression in hepatocytes were correlated closely with histological activity (grade) Of chronic viral hepatitis, but there were no correlations with histological stage, patient age or serum transaminase levels. Conclusion Apoptosis and its triggering molecule, Fas antigen, induce mechanisms that appear to be associated with the pathogenesis of chronic viral hepatitis.
ISSN: 0954-691X
Appears in Collections:Scopus
Web of Science

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