Stimulus properties of venlafaxine in a conditioned taste aversion procedure
Date
2008-10-31
Authors
Kayır, Hakan
Alıcı, Tevfik
Yıldırım, Murat
Ulusoy, Kemal Gökhan
Ceyhan, Mert
Çelik, Turgay
Uzbay, Tayfun
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Conditioned stimulus properties of venlafaxine are still unknown. In the present study, the discriminative stimulus properties of venlafaxine by using a conditioned taste aversion procedure were investigated. Swiss Webster mice were allowed to reach water from 2 pipettes for 20 min (09:00-11:30 h), plus 30 min (15:3016:00 h), daily. During the 4 days, the test drugs [fluoxetine, escitalopram, tianeptine, reboxetine, and N omega-nitro-L-arginine methyl ester(L-NAME)l were injected to mice at least 1 h after they had first water session. On day 5, they consumed glucose solution(5%w/v) and immediately injected with conditioning drug (venlafaxine 32 mg/kg). On day 8, mice were allowed to make a choice between water and glucose solution. The amount of glucose consumption as a percentage of total fluid intakes was calculated for each animal. Significant reduction in glucose choice was defined as conditioned taste aversion. Venlafaxine (32 mg/kg) induced a robust conditioned taste aversion in mice. Pre-exposure to tianeptine (2.5-10 mg/kg), fluoxetine (10 mg/kg), escitalopram (32 mg/kg), and reboxetine (5 mg/kg) substituted for venlafaxine by preventing the conditioned taste aversion induced by venlafaxine. L-NAME did not substitute for venlafaxine. Substitution of venlafaxine by fluoxetine, tianeptine, escitalopram, and reboxetine provides further evidence that both 5-HT and noradrenaline reuptake inhibition may play an important role in the stimulus effect of venlafaxine.
Description
Keywords
(Mice), Antidepressant, Conditioned taste aversion, Escitalopram, Fluoxetine, I- name, Reboxetine, Tianeptine, Venlafaxine, Serotonin reuptake inhibitor, Discriminative stimulus, Antidepressant, Citalopram, Drugs, Pharmacology & pharmacy
Citation
Kayır, H. vd. (2008). "Stimulus properties of venlafaxine in a conditioned taste aversion procedure". European Journal of Pharmacology, 596(1-3), 102-106.