Investigation of neuroprotective effects of cyclooxygenase inhibitors in the 6-hydroxydopamine induced rat Parkinson model
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Date
2009-07
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Türk Nöroşurji Derneği
Abstract
AIM: Recent experimental and clinical studies on Parkinson's disease point out the pivotal role of inflammation in the pathogenesis of neurodegeneration and the possible positive effects of nonsteroidal anti-inflammatory drug therapies. Our aim in this study was to investigate the preventive effects of nonsteroidal anti-inflammatory drugs in the 6-hydroxydopamine (6-OHDA) induced rat model of Parkinson's disease.
MATERIAL and METHODS: Twenty-one female Wistar-Albino rats (200-250g) were used in this study. The rats were divided in three groups: Saline group (n: 7, 2 ml), Acetylsalicylic acid group (n: 7, 100 mg/kg), and Meloxicam group (n: 7, 50 mg/kg). An hour after administration, the rats received a unilateral intranigral injection of 6-OHDA to produce the Parkinson model lesion. Rotational tests were performed two weeks later as follow-up. Immunohistochemical tests were performed in all groups to determine the severity of the lesion in the substantia nigra.
RESULTS: Administration of drugs an hour before the lesions were created did not protect the degeneration of dopaminergic neurons in the substantia nigra.
CONCLUSION: Oral usage of low repeated doses of nonsteroidal anfi-inflammatory drugs may possibly slow down the progression of the disease.
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Keywords
6-OHDA, NSAID, Parkinson model, Rat, Induced dopaminergic neurotoxicity, In-vivo microdialysis, Mptp-mouse model, Nf-kappa-b, Sodium-salicylate, Antiinflammatory drugs, 7-nitroindazole protects, Induced degeneration, Disease, Aspirin, Neurosciences & neurology, Surgery
Citation
Gören, B. vd. (2009). "Investigation of neuroprotective effects of cyclooxygenase inhibitors in the 6-hydroxydopamine induced rat Parkinson model". Turkish Neurosurgery, 19(3), 230-236.