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Title: Treatment results of 165 pediatric patients with non-metastatic nasopharyngeal carcinoma: A rare cancer network study
Authors: Özyar, Enis
Selek, Uğur
Laskar, Siddihartha
Uzel, Ömer
Anacak, Yavuz
Ben-Arush, Miriam
Polychronopoulou, Sopiha
Akman, Fadime
Wolden, Suzanne
Abacıoğlu, Ufuk
Miller, Robert C.
Özşahin, Mahmut
Abacıoğlu, Ufuk
Martin, Margarita
Caloğlu, Murat
Scandolaro, Luciano
Szutowicz, Eva
Atahan, Ibtisam Lale
Uludağ Üniversitesi/Tıp Fakültesi.
Sarıhan, Süreyya
Keywords: Radiology, nuclear medicine & medical imaging
Nasopharynx cancer
Issue Date: 2006
Publisher: Elsevier Ireland
Citation: Özyar, E. vd. (2006). ''Treatment results of 165 pediatric patients with non-metastatic nasopharyngeal carcinoma: A Rare Cancer Network study''. Radiotherapy and Oncology, 81(1), 39-46.
Abstract: Purpose: This Rare Cancer Network (RCN) study was performed in pediatric nasopharyngeal carcinoma (PNPC) patients to evaluate the optimal dose of radiotherapy and to determine prognostic factors. Patients and Methods: The study included 165 patients with the diagnosis of PNPC treated between 1978 and 2003. The median age was 14 years. There were 3 (1.8%) patients with stage I, 1 (0.6%) with IIA, 10 (6.1%) with IIB, 60 (36.4%) with III, 44 (26.7%) with IVA, and 47 (29%) with IVB disease. While 21 (12.7%) patients were treated with radiotherapy (RT) alone, 144 (87.3%) received chemotherapy and RT. The median follow-up time was 48 months. Results: The actuarial 5-year overall survival (OS) was 77.4% (95% CI: 70.06-84.72), whereas the actuarial 5-year disease-free survival (DFS) rate was 68.8% (95% CI: 61.33-76.31). In multivariate analysis, unfavorable factors were age > 14 years for LRC (p = 0.04); mate gender for DMFS (p = 0.03); T3/T4 disease for LRFS (p = 0.01); and N3 disease for DFS (p = 0.002) and OS (p = 0.002); EBRT dose of less than 66 Gy for LRFS (p = 0.02) and LRRFS (p = 0.0028); and patients treated with RT alone for LRFS (p = 0.0001), LRRFS (p = 0.007) and DFS (p = 0.02). Conclusion: Our results support the current practice of using combined radiation and chemotherapy for optimal treatment of NPC. However, research should be encouraged in an attempt to reduce the potential for long-term sequelae in pediatric patients given their relatively favorable prognosis and potential for longevity.
ISSN: 0167-8140
Appears in Collections:Scopus
Web of Science

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