Publication: Centrally administered choline increases plasma prolactin levels in conscious rats
Date
Authors
Gürün, Mine Sibel
Savcı, Vahide
Ulus, İsmail Hakkı
Kıran, Burhan K.
Authors
Advisor
Language
Type
Publisher:
Elsevier Science Ireland
Journal Title
Journal ISSN
Volume Title
Abstract
Intracerebroventricular (i.c.v.) administration of choline, a precursor of acetylcholine (ACh) increased plasma prolactin levels in a time and dose-dependent manner in conscious rats. Pretreatment of rats with the cholinergic muscarinic antagonist, atropine (10 mu g, i.c.v.), blocked the increase in plasma prolactin level. The increase was not influenced by pretreatment with the cholinergic nicotinic antagonist, mecamylamine (50 mu g, i.c.v.). Pretreatment with hemicholinium-3 (HC-3; 20 mu g, i.c.v.), a high affinity choline uptake inhibitor, attenuated the choline-induced increase of plasma prolactin levels. These results show that choline increases plasma prolactin levels by activating muscarinic receptors via presynaptic mechanisms.
Description
Source:
Keywords:
Keywords
Neurosciences & neurology, Choline, Acetylcholine, Prolactin, Atropine, Mecamylamine, Hemicholinium-3, Acetylcholine-release, Injected choline, Corpus striatum, Invivo release, Enhancement
Citation
Gürün, M. S. vd. (1997). "Centrally administered choline increases plasma prolactin levels in conscious rats". Neuroscience Letters, 232(2), 79-82.