Clinical importance of extended-spectrum beta-lactamase (PER-1-type)-producing Acinetobacter spp. and Pseudomonas aeruginosa strains
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Date
2001-07
Authors
Vahaboğlu, Haluk
Coşkukan, Figen
Tansel, Özlem
Öztürk, Recep
Şahin, Nursu
Köksal, İftihar
Kocazeybek, Bekir
Tatman, Müşerref Otkun
Leblebicioğlu, Hakan
Özinel, Mehmet Ali
Journal Title
Journal ISSN
Volume Title
Publisher
Lippincott Williams & Wilkins
Abstract
Recently, an extended-spectrum beta -lactamase (PER-I) was found to be disseminated among Acinetobacter spp, and Pseudomonas aeruginosa isolates in Turkey. A population-based cohort study was conducted to elucidate predictive mortality factors in patients with nosocomial infections caused by Acinetobacter spp. and P. aeruginosa, with particular reference to PER-1-type extended-spectrum beta -lactamase (ESBL) production. The study group comprised 16 and 21 non-survivors and 82 and 126 survivors in cohorts infected with Acinetobacter and E. aeruginosa, respectively. In the Acinetobacter-infected cohort, nosocomial pneumonia, hypotension and infection with a PER-positive isolate were independent predictors of mortality. In the P. aeruginosa-infected cohort, impaired consciousness, a PER-positive isolate, male sex and (with a negative relative risk) urinary tract infection were independent predictors of death. This study demonstrated the relationship of PER-1-type ESBL-producing Acinetobacter spp. and P. aeruginosa with poor clinical outcome.
Description
Keywords
Microbiology, Outer-membrane, Resistance, Baumannii, Acquisition, Pneumonia, Mortality, Outbreak
Citation
Vahaboğlu, H. vd. (2001). "Clinical importance of extended-spectrum beta-lactamase (PER-1-type)-producing Acinetobacter spp. and Pseudomonas aeruginosa strains". Journal of Medical Microbiology, 50(7), 642-645.