The effects of azone and capsaicin on the permeation of naproxen through human skin

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Date

1999-03-01

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier Science BV

Abstract

The permeation of naproxen through excised human skin and isolated perfused rabbit ear skin has been determined. It was found that both Atone and capsaicin enhanced the permeation with an enhancement ratio of up to 4-fold. The magnitudes of the effect were similar in human and rabbit skin. The permeation of naproxen from a saturated solution of the drug through skin pre-treated with Atone was similar to that from a commercial preparation (Naprosyn). In the perfused rabbit ear experiments the presence of capsaicin had no effect on the vasodilatation of the blood vessels, inferring that the penetration enhancement was a direct result of capsaicin influencing the barrier function of the skin. Structural similarities between Atone and capsaicin were seen using molecular graphics.

Description

Keywords

Azone, Capsaicin, Naproxen, Penetration enhancers, Skin absorption, Pharmacology & pharmacy

Citation

Degim, İ. T. vd. (1999). "The effects of azone and capsaicin on the permeation of naproxen through human skin". International Journal of Pharmaceutics, 179(1), 21-25.

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