The effects of azone and capsaicin on the permeation of naproxen through human skin

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dc.contributor.authorDegim, İ. Tuncer
dc.contributor.authorUslu, A.
dc.contributor.authorHadgraft, Jonathan
dc.contributor.authorAtay, T.
dc.contributor.authorCevheroğlu, S.
dc.contributor.buuauthorAkay, Cemal
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi.tr_TR
dc.contributor.orcid0000-0002-2306-5451tr_TR
dc.contributor.researcheridAAA-7011-2021tr_TR
dc.date.accessioned2021-06-29T10:08:10Z
dc.date.available2021-06-29T10:08:10Z
dc.date.issued1999-03-01
dc.description.abstractThe permeation of naproxen through excised human skin and isolated perfused rabbit ear skin has been determined. It was found that both Atone and capsaicin enhanced the permeation with an enhancement ratio of up to 4-fold. The magnitudes of the effect were similar in human and rabbit skin. The permeation of naproxen from a saturated solution of the drug through skin pre-treated with Atone was similar to that from a commercial preparation (Naprosyn). In the perfused rabbit ear experiments the presence of capsaicin had no effect on the vasodilatation of the blood vessels, inferring that the penetration enhancement was a direct result of capsaicin influencing the barrier function of the skin. Structural similarities between Atone and capsaicin were seen using molecular graphics.en_US
dc.identifier.citationDegim, İ. T. vd. (1999). "The effects of azone and capsaicin on the permeation of naproxen through human skin". International Journal of Pharmaceutics, 179(1), 21-25.en_US
dc.identifier.endpage25tr_TR
dc.identifier.issn0378-5173
dc.identifier.issue1tr_TR
dc.identifier.pubmed10053198tr_TR
dc.identifier.scopus2-s2.0-0033011269tr_TR
dc.identifier.startpage21tr_TR
dc.identifier.urihttps://doi.org/10.1016/S0378-5173(98)00353-6
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0378517398003536
dc.identifier.urihttp://hdl.handle.net/11452/20899
dc.identifier.volume179tr_TR
dc.identifier.wos000079392100002tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevier Science BVen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalInternational Journal of Pharmaceuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAzoneen_US
dc.subjectCapsaicinen_US
dc.subjectNaproxenen_US
dc.subjectPenetration enhancersen_US
dc.subjectSkin absorptionen_US
dc.subjectPharmacology & pharmacyen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleThe effects of azone and capsaicin on the permeation of naproxen through human skinen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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