Pulmoner hamartomlar: 30 olgunun klinikopatolojik değerlendirilmesi
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Date
2016-04-21
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Uludağ Üniversitesi
Abstract
Pulmoner hamartomlar, akciğerin en sık görülen benign tümörleridir. Genellikle soliter olup akciğerin periferinde yerleşirler. Mezenşimal hücrelerden köken alan bu tümörler matür kıkırdak, yağ, osteoid ve düz kas dokularının değişen miktarlarda birleşiminden oluşurlar. Çalışmamızda 2005 ile 2014 yılları arasında Patoloji Anabilim Dalı’nda pulmoner hamartom tanısı almış 30 olgu dahil edilmiştir. Hastalar, yaş, cinsiyet, hastanın başvuru sırasındaki şikayeti, klinik ve/veya radyolojik ön tanı, tümör yerleşim yeri, ameliyat prosedürü, tümör boyutu ve histopatolojik bulgular açısından retrospektif olarak değerlendirilmiştir. Olguların 20’si erkek, 10’u kadın olup erkek/kadın oranı 2’dir. Yaş ortalaması 54.5 yaş (aralık 27–75 yaş) olarak bulunmuştur. En sık görülen yakınma öksürük olup semptomatik olan 18 hastanın 14’ünde (%78) mevcuttur. Hastaların 16’sında (%53) tümör sağ akciğer yerleşimlidir. Hastaların biri hariç hepsine wedge rezeksiyon uygulanmıştır. Makroskopik incelemede ortalama tümör çapı 2.1 cm (aralık 0.3–9 cm) olarak tespit edilmiştir. Olguların tamamı soliter olup, bir olguda hamartom ile aynı lobda yerleşmiş akciğer kökenli adenokarsinom saptanmıştır. Makroskopik incelemede, pulmoner hamartomlara nadir de olsa malignitenin eşlik edebileceği akılda tutulmalı ve lezyon dışı akciğer parankimi dikkatlice incelenmeli ve örneklenmelidir.
Pulmonary hamartomas are the most common benign tumors of lung. They are mostly solitary, and are located peripherally. These tumors are composed of varying amounts of cartilage, fatty, smooth muscle and fibrous tissue as they originate from mesenchymal cells. Thirty cases, which were diagnosed as pulmonary hamartoma at the Department of Pathology between 2005 and 2014, were examined retrospectively in this study. Patients’ data including age, sex, complaint, clinical and/or radiological diagnosis, tumor localization, surgical procedure, tumor size, and histopathological findings were recorded. Of the 30 cases, 20 were male and 10 were female, with a male-to-female ratio of 2. The age range of the study population was between 25 and 75 years, and the mean age was 54.5 years. The most common complaint was cough, which was present in 78% symptomatic patients (14 out of 18). In 16 (53%) patients, tumor was localized in the right lung. Wedge resection was performed in all patients except one. In macroscopic examination, tumor size ranged between 0.3 cm and 9 cm, with a mean size of 2.1 cm. One patient was detected to have an adenocarcinoma of lung originating from the same lobe as hamartoma. It should always be kept in mind that a malignancy may accompany a pulmonary hamartoma. Therefore, the nontumoral parenchyma should be carefully examined and sampled during the macroscopic dissection.
Pulmonary hamartomas are the most common benign tumors of lung. They are mostly solitary, and are located peripherally. These tumors are composed of varying amounts of cartilage, fatty, smooth muscle and fibrous tissue as they originate from mesenchymal cells. Thirty cases, which were diagnosed as pulmonary hamartoma at the Department of Pathology between 2005 and 2014, were examined retrospectively in this study. Patients’ data including age, sex, complaint, clinical and/or radiological diagnosis, tumor localization, surgical procedure, tumor size, and histopathological findings were recorded. Of the 30 cases, 20 were male and 10 were female, with a male-to-female ratio of 2. The age range of the study population was between 25 and 75 years, and the mean age was 54.5 years. The most common complaint was cough, which was present in 78% symptomatic patients (14 out of 18). In 16 (53%) patients, tumor was localized in the right lung. Wedge resection was performed in all patients except one. In macroscopic examination, tumor size ranged between 0.3 cm and 9 cm, with a mean size of 2.1 cm. One patient was detected to have an adenocarcinoma of lung originating from the same lobe as hamartoma. It should always be kept in mind that a malignancy may accompany a pulmonary hamartoma. Therefore, the nontumoral parenchyma should be carefully examined and sampled during the macroscopic dissection.
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Keywords
Akciğer, Pulmoner hamartom, Tümör, Lung, Pulmonary hamartoma, Tumor
Citation
Sayar, A. vd. (2016). “Pulmoner hamartomlar: 30 olgunun klinikopatolojik değerlendirilmesi”. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 42(1), 19-22.