Paratiroid hormon ilişkili protein
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Date
2000-04-20
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Uludağ Üniversitesi
Abstract
Son zamanlarda, paratiroid hormon-ilişkili protein (PTHrP), çeşitli türlerde kötü huylu tümörterin humoral hiperkalsemisinin en önemli nedenlerinden biri olarak teşhis edilmiştir. Bununla birlikte,bu hormonun memeli ve kuşların fizyoloji ve pathofizyolojisinde önemli bir role sahip olduğu, birçok endokrin, parakrin ve otokrin fonksi yonları olduğu bildirilmektedir. PTHrP, paratiroid hormon ile aynı reseptörleri paylaşır. Bu reseptörler bir çok dokuda belirlenmiştir. PTHrP u yönüyle paratiroid hormona benzemez; paratiroid hormon (parathormon,PTH) paratiroid bezlerin ürünüdür. PTHrP ise meme bezlerini de kapsayan bir çok dokuda geniş ağılıma sahiptir. Paratiroid hormon ilişkili protein hem fötal hem de ergin, hemen hemen tüm dokuların ürünüdür ve parakrine otokrine tarzda çeşitli fizyolojik işlevleri vardır. PTHrP önemli bir fötal büyüme faktörüdür, embriyonik ve ergin dokuların büyüme ve gelişimin de, kemik ve böbreklerde, hücresel farklılaşmada, düz kasların gevşemesinde, laktasyonda kalsiyum ve magnezyum taşınmasın a önemli rolü olduğu bildirilmiştir.
Recently, parathyroid hormone-related protein (PTHrP) was identifıed as one of the major causes of humoral hypercalcemia of malignaney in several speeies. However, this hormone has an im portant role in the physiology and pathophysiology of marnınal s and birds. Many endoerine, paraerine and autocrine functions are attributed to PTHrP. PTHrP shares the same receptar with parathromone. This receptar was isolated in many tissues. Unlike parathyroid hormone (parathormone,PTH), a produet of the parathyroid glands,parathyroid hormone-related protein has a wide dis!fibution in tissues, including the mammary gland. Parathyroid hormone-related protein is a produet of almost all normal tissues, both fetal and adult, and plays diverse physiologic roles in a paraerine autocrine fashion. PTHrP was identified as a substance having an important fetal growth and development of both embryonie and mature tissues,in bone and kidney, in cellular differentiation, in smooth mucle relaxation, lactation and calcium and magnesium transport.
Recently, parathyroid hormone-related protein (PTHrP) was identifıed as one of the major causes of humoral hypercalcemia of malignaney in several speeies. However, this hormone has an im portant role in the physiology and pathophysiology of marnınal s and birds. Many endoerine, paraerine and autocrine functions are attributed to PTHrP. PTHrP shares the same receptar with parathromone. This receptar was isolated in many tissues. Unlike parathyroid hormone (parathormone,PTH), a produet of the parathyroid glands,parathyroid hormone-related protein has a wide dis!fibution in tissues, including the mammary gland. Parathyroid hormone-related protein is a produet of almost all normal tissues, both fetal and adult, and plays diverse physiologic roles in a paraerine autocrine fashion. PTHrP was identified as a substance having an important fetal growth and development of both embryonie and mature tissues,in bone and kidney, in cellular differentiation, in smooth mucle relaxation, lactation and calcium and magnesium transport.
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Keywords
Paratiroid hormon, Parathyroid hormon, Böbreklerde PTHrP, Kemiklerde PTHrP
Citation
Cengiz, F. (2000). "Paratiroid hormon ilişkili protein" Uludağ Üniversitesi Veteriner Fakültesi Dergisi, 19(3),163-168.