Publication:
Do morphologic characteristics play a role in nodal metastatic progression of well-differentiated pancreatic neuroendocrine tumors?

dc.contributor.buuauthorHasdemir, Seçil
dc.contributor.buuauthorHASDEMİR, SEÇİL
dc.contributor.buuauthorUgraş, Nesrin
dc.contributor.buuauthorUĞRAŞ, NESRİN
dc.contributor.buuauthorYerci, Omer
dc.contributor.buuauthorYERCİ, ÖMER
dc.contributor.buuauthorTasar, Pınar
dc.contributor.buuauthorTAŞAR, PINAR
dc.contributor.buuauthorDundar, Halit Ziya
dc.contributor.buuauthorDÜNDAR, HALİT ZİYA
dc.contributor.buuauthorMacunluoğlu, Aslı Ceren
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentGenel Cerrahi Ana Bilim Dalı
dc.contributor.orcid0000-0003-1769-7484
dc.contributor.orcid0000-0002-6802-5998
dc.contributor.researcheridAAH-2716-2021
dc.date.accessioned2024-07-05T11:46:15Z
dc.date.available2024-07-05T11:46:15Z
dc.date.issued2020-07-24
dc.description.abstractBackground: Pancreatic neuroendocrine neoplasms (NENs) are tumors with histopathologic and prognostic heterogeneity that pose difficulties in establishing standards for diagnosis, classification, and treatment. Among NENs, well-differentiated neuroendocrine tumors (NETs) have been classified as grade 1, 2, and 3 in the most recently released World Health Organization classification. Although well-differentiated NETs are associated with relatively better prognosis, they have a potential for malignant behavior such as extrapancreatic spread, metastasis, or recurrence. The present study aimed to evaluate clinical and histomorphologic findings of patients with well-differentiated pancreatic NETs and to identify histopathologic findings effective in predicting nodal metastatic progression. Methods: The study group consisted of 54 patients diagnosed with well-differentiated NET. All preparations and blocks of the patients were examined for the following histopathologic parameters: tumor diameter, microscopic tumor growth pattern (solid, trabecular, acinar, and mixed), cellular features (clear, eosinophilic, oncocytic, peliotic, and pseudopapillary), stromal changes (calcification, lymphocytic infiltration, and stromal hyalinization), presence of necrosis, perineural invasion, lymphovascular invasion, mitotic activity, and Ki67 proliferative index. Results: Lymph node metastasis was present in 7 patients. Lymph node metastasis was significantly associated with tumor diameter of >2 cm (p= 0.012), Ki67 proliferative index of >20% (p= 0.022), grade 3 tumors (p= 0.002), presence of dense stromal hyalinization (p= 0.034), and mild lymphocytic infiltration (p= 0.041). Conclusion: The present study revealed that the new findings such as presence of dense stromal hyalinization and absence of remarkable lymphocytic infiltration could be predictive morphologic findings for the development of lymph node metastasis.
dc.identifier.doi10.1177/0300891620941921
dc.identifier.endpage85
dc.identifier.issn0300-8916
dc.identifier.issue1
dc.identifier.startpage80
dc.identifier.urihttps://doi.org/10.1177/0300891620941921
dc.identifier.urihttps://hdl.handle.net/11452/42983
dc.identifier.volume107
dc.identifier.wos000556058700001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.journalTumori Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGrade
dc.subjectNeuroendocrine tumor
dc.subjectPancreas
dc.subjectMorphologic findings
dc.subjectNodal metastasis
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectOncology
dc.titleDo morphologic characteristics play a role in nodal metastatic progression of well-differentiated pancreatic neuroendocrine tumors?
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Genel Cerrahi Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Patoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Bioistatistik Ana Bilim Dalı
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relation.isAuthorOfPublication559e3ec8-742a-46d4-bf58-8bb138ca553d
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relation.isAuthorOfPublication.latestForDiscovery5e129638-8221-4fc2-8956-7c31d3fea07b

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