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Retrospective analysis of vitamin D status on inflammatory markers and course of the disease in patients with COVID-19 infection

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dc.contributor.authorÜnsal, Yasemin Aydoğan
dc.contributor.authorGül, Özen Öz
dc.contributor.authorCander, Soner
dc.contributor.authorErsoy, Canan
dc.contributor.authorAydemir, Ensar
dc.contributor.authorAteş, Coşkun
dc.contributor.authorUzun, Ziya
dc.contributor.authorArmağan, Ersin
dc.contributor.authorÜnsal, Oktay
dc.contributor.authorErtürk, Elif
dc.contributor.buuauthorAYDOĞAN ÜNSAL, YASEMİN
dc.contributor.buuauthorÖZ GÜL, ÖZEN
dc.contributor.buuauthorCANDER, SONER
dc.contributor.buuauthorERSOY, CANAN
dc.contributor.buuauthorAYDEMİR, ENSAR
dc.contributor.buuauthorATEŞ, COŞKUN
dc.contributor.buuauthorERTÜRK, ELİF
dc.contributor.buuauthorArmağan, Ersin
dc.contributor.buuauthorUzun, Ziya
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi
dc.contributor.orcid0000-0002-1566-3099
dc.contributor.orcid 0000-0002-1332-4165
dc.contributor.orcid 0000-0001-6303-7896
dc.contributor.orcid 0000-0001-8519-784X
dc.contributor.orcid0000-0003-4565-9848
dc.contributor.orcid0000-0003-1363-2966
dc.contributor.researcheridHSE-4469-2023
dc.contributor.researcheridGBT-4320-2022
dc.contributor.researcheridCJH-1319-2022
dc.contributor.researcheridAAH-8861-2021
dc.contributor.researcheridAAB-6671-2022
dc.contributor.researcheridCDO-0747-2022
dc.contributor.researcheridGQW-5454-2022
dc.contributor.researcheridCBW-8706-2022
dc.contributor.researcheridJQI-3400-2023
dc.date.accessioned2024-06-25T13:33:00Z
dc.date.available2024-06-25T13:33:00Z
dc.date.issued2021-04-05
dc.description.abstractPurpose The aim of the study was to investigate the association between serum 25-hydroxyvitamin D status within the last 6 months prior to COVID-19 infection and parameters of immune function and clinical outcomes. Methods Fifty-six patients, who were admitted to the emergency clinic and diagnosed with COVID-19 infection, were included in the study. Data on clinical characteristics, inflammatory parameters and vitamin D status were recorded for each patient. All the participants had data on 25-hydroxyvitamin D status within the last 6 months prior to COVID-19 infection. Results The patients were stratified as those with vitamin D status less than 20 ng/mL and higher than 20 ng/mL. A group with vitamin D status less than 20 ng/mL had lower lymphocyte counts and lower haemoglobin levels that was statistically significant (respectively; p = 0.021, p = 0.035). Higher C-reactive protein (CRP) levels were seen in the vitamin D-deficient group (p = 0.013). It was observed that vitamin D status of the patients who required oxygen therapy were lower than those who did not require oxygen therapy, not statistically significant (p = 0.05). Patients who did not use vitamin D supplementation within 6 months prior to COVID-19 infection had more likely to be diagnosed with pneumonia (p = 0.004). Conclusion Cases with lower vitamin D status had increased inflammatory markers and worse clinical outcomes than patients with higher vitamin D status. This study suggests that vitamin D status can be used as a prognostic factor in COVID-19 patients, and vitamin D supplementation can be recommended to improve the clinical outcomes in COVID-19 infection.
dc.description.sponsorshipSociety of Endocrinology and Metabolism of Turkey
dc.identifier.doi10.1007/s40618-021-01566-9
dc.identifier.endpage2607
dc.identifier.isbn1720-8386
dc.identifier.issn0391-4097
dc.identifier.issue12
dc.identifier.pubmed33818731
dc.identifier.startpage2601
dc.identifier.urihttps://doi.org/10.1007/s40618-021-01566-9
dc.identifier.urihttps://link.springer.com/article/10.1007/s40618-021-01566-9
dc.identifier.urihttps://hdl.handle.net/11452/42385
dc.identifier.volume44
dc.identifier.wos000636911700001
dc.indexed.pubmedPubMed
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSpringer
dc.relation.journalJournal of Endocrinological Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectVitamin D
dc.subjectCovid-19
dc.subjectImmunity
dc.subjectAnti-inflammatory
dc.subjectPneumonia
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectEndocrinology & metabolism
dc.titleRetrospective analysis of vitamin D status on inflammatory markers and course of the disease in patients with COVID-19 infection
dc.typeArticle
dspace.entity.typePublication
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