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Short and long term effects of granulocyte colony-stimulating factor during induction therapy in acute myeloid leukemia patients younger than 65: Results of a randomized multicenter phase III trial

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dc.contributor.authorBeksaç, Meral
dc.contributor.authorÖzcan, Muhit
dc.contributor.authorÖzçebe, Osman
dc.contributor.authorBayık, Mahmut
dc.contributor.authorPaydaş, Semra
dc.contributor.authorBüyükaşık, Yahya
dc.contributor.authorİlhan, Osman
dc.contributor.authorGürman, Günhan
dc.contributor.authorUysal, Akın
dc.contributor.authorAkan, Hamdi
dc.contributor.authorSoydan, Ender Akcağlayan
dc.contributor.buuauthorAli, Ridvan
dc.contributor.buuauthorÖzçelik, Tülay
dc.contributor.buuauthorÖzkalemkaş, Fahir
dc.contributor.buuauthorTunalı, Ahmet
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentHematoloji Ana Bilim Dalı
dc.contributor.researcheridAAG-8495-2021
dc.contributor.scopusid7201813027
dc.contributor.scopusid7005424333
dc.contributor.scopusid6601912387
dc.date.accessioned2022-03-16T06:25:28Z
dc.date.available2022-03-16T06:25:28Z
dc.date.issued2011-03
dc.description.abstractThis prospective multicenter phase III clinical trial was designed to assess efficacy and safety of G-CSF as an adjunct to de novo AML remission induction therapy (www.clinicaltrials.gov.NCT00820976). Patients' characteristics were similar in both arms. G-CSF improved severity and duration of leukopenia. Three-year OS were similar (25.6 +/- 5.1% vs. 31.8 +/- 5.6%) in both arms except for patients with myeloblastic features. Significant factors for better survival were the use of G-CSF (p = 0.049), female sex (p = 0.05) and single induction cycle (p < 0.001) in multivariate analysis. Female patients performed better than male patients. Better survival obtained among female AML patients needs to be validated within the context of cytogenetic analysis.
dc.identifier.citationBeksaç, M. vd. (2011). "Short and long term effects of granulocyte colony-stimulating factor during induction therapy in acute myeloid leukemia patients younger than 65: Results of a randomized multicenter phase III trial". Leukemia Research, 35(3), 340-345.
dc.identifier.doi10.1016/j.leukres.2010.07.005
dc.identifier.endpage345
dc.identifier.issn0145-2126
dc.identifier.issn1873-5835
dc.identifier.issue3
dc.identifier.pubmed20673585
dc.identifier.scopus2-s2.0-79952105259
dc.identifier.startpage340
dc.identifier.urihttps://doi.org/10.1016/j.leukres.2010.07.005
dc.identifier.urihttp://hdl.handle.net/11452/25062
dc.identifier.volume35
dc.identifier.wos000287965100019
dc.indexed.wosSSCI
dc.language.isoen
dc.publisherPergamon-Elsevier Science
dc.relation.collaborationYurt içi
dc.relation.journalLeukemia Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOncology
dc.subjectHematology
dc.subjectGranulocyte colony-stimulating factor
dc.subjectAcute myeloid leukemia
dc.subjectInduction
dc.subjectSurvival
dc.subjectAcute myelogenous leukemia
dc.subjectPlacebo-controlled trial
dc.subjectSouthwest-oncology-group
dc.subjectElderly-patients
dc.subjectDouble-blind
dc.subjectAdult patients
dc.subjectGrowth-factors
dc.subjectG-csf
dc.subjectFebrile neutropenia
dc.subjectPrognostic-factors
dc.subject.emtreeCytarabine
dc.subject.emtreeIdarubicin
dc.subject.emtreeRecombinant granulocyte colony stimulating factor
dc.subject.emtreeAcute febrile neutrophilic dermatosis
dc.subject.emtreeAcute granulocytic leukemia
dc.subject.emtreeAdolescent
dc.subject.emtreeAdult
dc.subject.emtreeAllogeneic peripheral blood stem cell transplantation
dc.subject.emtreeArticle
dc.subject.emtreeAutologous peripheral blood stem cell transplantation
dc.subject.emtreeBone marrow biopsy
dc.subject.emtreeCapillary leak syndrome
dc.subject.emtreeChromosome analysis
dc.subject.emtreeControlled study
dc.subject.emtreeDisease duration
dc.subject.emtreeDisease severity
dc.subject.emtreeDrug efficacy
dc.subject.emtreeDrug eruption
dc.subject.emtreeDrug fever
dc.subject.emtreeDrug safety
dc.subject.emtreeFemale
dc.subject.emtreeHuman
dc.subject.emtreeHuman tissue
dc.subject.emtreeInfection
dc.subject.emtreeLeukemia remission
dc.subject.emtreeLeukopenia
dc.subject.emtreeMajor clinical study
dc.subject.emtreeMale
dc.subject.emtreeMulticenter study
dc.subject.emtreeMultiple cycle treatment
dc.subject.emtreeMusculoskeletal pain
dc.subject.emtreeMyoblast
dc.subject.emtreeNeutrophil count
dc.subject.emtreeOverall survival
dc.subject.emtreePriority journal
dc.subject.emtreeProspective study
dc.subject.emtreeRandomized controlled trial
dc.subject.emtreeSex difference
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshDrug resistance, neoplasm
dc.subject.meshFemale
dc.subject.meshGranulocyte colony-stimulating factor
dc.subject.meshHumans
dc.subject.meshLeukemia, myeloid, acute
dc.subject.meshMale
dc.subject.meshMiddle aged
dc.subject.meshNeoplasm recurrence, local
dc.subject.meshNeutropenia
dc.subject.meshRemission induction
dc.subject.meshSurvival rate
dc.subject.meshTime factors
dc.subject.meshTreatment outcome
dc.subject.meshYoung adult
dc.subject.scopusCytarabine; Acute Myeloid Leukemia; Remission
dc.subject.wosOncology
dc.subject.wosHematology
dc.titleShort and long term effects of granulocyte colony-stimulating factor during induction therapy in acute myeloid leukemia patients younger than 65: Results of a randomized multicenter phase III trial
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Hematoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS

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